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HBV infection from birth and during Adult age Difference
Hi All,
Wanted to check if anyone of you have read some where or if you have any idea on my clarification:
Assume that, if a person has HBV infection from birth and it takes around 40-50 years to get the liver failure if it's not noticed.
If the person gets HBV infection when he is 30 years old and if he becomes chronic, how long it might take to get the liver failure if it's not noticed? Is it again 40-50 years after infection?
Wanted to check if anyone of you have read some where or if you have any idea on my clarification:
Assume that, if a person has HBV infection from birth and it takes around 40-50 years to get the liver failure if it's not noticed.
If the person gets HBV infection when he is 30 years old and if he becomes chronic, how long it might take to get the liver failure if it's not noticed? Is it again 40-50 years after infection?
Best Answer
@hepbcurepls with someone that has fibroscan shows 7.8kpa f1/f2 with HBV DNA of 7998 IU/L presently @37 yrs does such people have chance to beat the HBV ,stop the disease progression and regress the fibrosis ? And what do you think is the best treatment option HBEAG negetive ? Peg interferon or tenofovir ?
However, we should not be to concerned about survival statistics etc....the main thing is to lead a healthy lifestyle, exercise, be fit, go for regular checkups so as to follow the virus, be on treatment if required.
Do the best we can do, then put it in the hands of God and live a life...
Do the best we can do, then put it in the hands of God and live a life...
With regular 6 monthly ultrasound + AFP tests, survival past 5 years from the time of finding out HCC is now over 50%.
With that said, the best mode of HCC screening would be MRI + AFP, this would increase chances of survival even more as it would be able to detect HCC earlier for some of people, but it is very expensive to do every 6 months, thus they send us to do ultrasound.
With that said, the best mode of HCC screening would be MRI + AFP, this would increase chances of survival even more as it would be able to detect HCC earlier for some of people, but it is very expensive to do every 6 months, thus they send us to do ultrasound.
I have no idea how long Immune Control Phase lasts, it is determined by the viral and host factors. It may last for ever, or patients may lose HbsAg or the virus mutates (Core/Basal Core Promotor) and treatment is then needed.
Most patients infected at birth, e-seroconvert before the age of 40, Genotype C takes the longer time. Most emerged from the Immune Tolerance phase with some degree of Fibrosis. Those infected as an adult, I think, have a healthier liver when they entered the Immune Control phase (assuming no drinking or other metabolic diseases).
Just my understanding.
Most patients infected at birth, e-seroconvert before the age of 40, Genotype C takes the longer time. Most emerged from the Immune Tolerance phase with some degree of Fibrosis. Those infected as an adult, I think, have a healthier liver when they entered the Immune Control phase (assuming no drinking or other metabolic diseases).
Just my understanding.
He had HCC last year and had chemoembolization treatment. They caught it early. they basically cut off blood circulation to the one of the veins in the liver and injected chemo into the tumor. So far its been good. That is the reason we must always check are livers with ultrasounds and afp. If we catch hcc early we have a better chance. Yes liver cancer survival rates are low because it is always caught late and no symptoms.
Thanks hepbcutepls. Somewhere I read that maximum survival age after HCC is 5 years. Really surprised to see that your uncle is on medication for HCC since more than 16 years. Thats very good. Thanks.
Yes hbv can become hcc anytime that is why we monitor two times a year. The chances are relatively small without cirrhosis but there still is a chance. Also certain genotypes , mutations and family history is a large contributing factor for hbv to convert to hcc without cirrhosis. This is the taboo of hep b as oppsose to hep c there must be corrhosis for hcc
Hi hepbcurepls,
I wanted one more info, one of your uncles is with HCC treatment since 99/00?
I wanted one more info, one of your uncles is with HCC treatment since 99/00?
Hi Stephen,
Thanks for your Valuable statistics. Do we have any idea on how long Immune Control phase lasts for the person who affected as an adult? Will it be shorter than Immune Tolerant and Immune Clearance phases?
Can Immune Tolerant phase can last for 30 years or 40 years like that? I think in this phase treatment may not be required as it's considered as "Inactive Phase"? Thanks.
Thanks for your Valuable statistics. Do we have any idea on how long Immune Control phase lasts for the person who affected as an adult? Will it be shorter than Immune Tolerant and Immune Clearance phases?
Can Immune Tolerant phase can last for 30 years or 40 years like that? I think in this phase treatment may not be required as it's considered as "Inactive Phase"? Thanks.
Thanks for your valuable statistics hepbcurepls.I didn't get what is 99/00 ? Looking at this statistics, one can live with good health atleast for 70 years if they start taking treatment. Thanks.
on my mothers side, my grandmother 2 uncles , my mother and I all were born with hep b.
my grandmother passed away at 71 portal hypertension aneurysm / liver failure (took her 71 years before liver failure)
my mother is 65 and so far ok on meds (no cirrhosis , just trying to dodge hcc like the rest of us)
uncle 63 with liver cirrhosis (his immune system made damage earlier at a young age, when we found out about hep b in our family he had cirrhosis already)
uncle 61 had hcc.( had random hcc last year, no cirrhosis of the liver)
grandmother never had treatment
uncle cirrhosis treatment around 99/00 so basically puts him at 46 or 47 age
uncle hcc treatment around 99/00 so treatment around 44 age
mother treatment around 99/00 treatment around 50 age
we are all carriers from birth i am 36 treatment age 36.
my grandmother passed away at 71 portal hypertension aneurysm / liver failure (took her 71 years before liver failure)
my mother is 65 and so far ok on meds (no cirrhosis , just trying to dodge hcc like the rest of us)
uncle 63 with liver cirrhosis (his immune system made damage earlier at a young age, when we found out about hep b in our family he had cirrhosis already)
uncle 61 had hcc.( had random hcc last year, no cirrhosis of the liver)
grandmother never had treatment
uncle cirrhosis treatment around 99/00 so basically puts him at 46 or 47 age
uncle hcc treatment around 99/00 so treatment around 44 age
mother treatment around 99/00 treatment around 50 age
we are all carriers from birth i am 36 treatment age 36.
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The figures I read often in the literature are roughly 30% of patients infected at birth will develop cirrhosis/HCC in their 50/60s if not treated.
For patients infected as an adult, the Immune Tolerance and Immune Clearance phases are usually very short. So it all depends on how long the Immune Control phase last.
HBV affects everyone differently, the only safe way is to check up regularly and get treated when it is necessary.
Hope I got it right.