HBV viral load

[pinkyjelly24]

My dad has HBV viral load 74.3IU/ml. ALT 35,fibroscan normal, HBe Ag negative, Any further management for him?

[pinkyjelly24]

Genotype cant b determined in our country. It s not available here. What should i do ?

[stef2011]

it is abnormal but not yet allarming, if it goes at 7kpa it is better to treat at ages over 45-50yo, if it comes out genotype is C it is best to treat indipendently from serum or fibroscan due to the high hcc risk

[pinkyjelly24]

Fibroscan 6.8kPa

[pinkyjelly24]

Fibroscan 6.8kPa

[stef2011]

sorry mistake:

and get rid of hbsag definitely because this sequential treatment has a very high percentage of hbsag clearance

you may also just monitor by US every 6 months and fibroscan every year, so if a liver cancer is detected you re on time for resection by this strict monitroing

[stef2011]

what is fibroscan result?normal is too generic, what is the kpa number?

the age is very important because after 45-50years old the risk of liver cancer is increased and high hbsag also correlates to liver cancer risk on hbeag negative:

it is best to know hbv genotype, history of liver cancer in the family and precore, bcp mutations

if you want to be very very safe on liver cancer after you know hbv genotype you d best start tenofovir and add peginterferon when hbsag lowers to 1500iu/ml or less or get rid of hbsag definitely

in your case liver cancer is increased because:
hbsag is more than 1000iu/ml (on asian genotypes B and C lower hbsag may be required to lower cancer risk)

genotype C is very dangerous for liver cancer

mutations like precore and bcp, probably present at this age, are at very high risk of liver cancer

you may also just monitor

[pinkyjelly24]

Thanks to both of u.
His age is 53years. HBsAg quantity is 3900.

[Soflab]

Could you please relay you Dad age and when did he discovered HBSag positive.
It would be wiser to do one more test HBSag quant to nonitor as well how many cells are infected on tyhe cliver and as stephen suggested regular checks every 6 months is the result did not have major changesafter 1 year then test every year but if affordable i would tyest every 6 months.

[StephenCastlecrag]

I am not a doctor. Your Dad's viral load is low and ALT is normal. If the Fibroscan indicates he has minimal or no fibrosis, then I would think treatment is not needed at the moment Please do make sure he has regular checkups.

Just my opinion.