HBeAb is reactive

[hepa114]

below are my latest reports after continuing "Tenvir" for almost 1 year 2 months.
on 15/12/2012
HBeAg Positive
Test Value 4.48 cutoff rate 0.10
HBeAb Negative cutoff rate 0.40
after this i started taking the "Tenvir" tab.

on 05/02/2011
SGOT: 81   [15-37]
SGPT: 150   [30-65]

on 23/04/2011
SGOT: 37   [15-37]
SGPT: 54   [30-65]

on 23/07/2011
SGOT: 30  [15-37]
SGPT: 49   [30-65]
HBeAb - Reactive 0.264 Ref Range  1.0 Non-Reactive
HbeAg - Reactive 4.09 Ref Range  1.0 Reactive

on 17/04/2012
SGOT: 30  [15-37]
SGPT: 50   [30-65]
LFT Normal
HBeAb - Reactive 0.831 Ref Range  1.0 Non-Reactive
HbeAg - Reactive 2.07 Ref Range  1.0 Reactive
DNA LOAD - report awaited

Based on these results could you please tell me my health condition. since HBeAb is reactive (positive i hope) did i have achieved the "seroconversion" stage and not more treatment required.
from last month i have stopped taking the "Tenvir" tab and going to meet the Dr after DNA Load report.
can i start the Tenvir tab again to make HBeAg also negative.
what does 0.831 or 2.07 number mean? or 0.264 and 4.09 mean? if these number goes down mean virus load is coming down?

[stef2011]

if you have no contribution to this community (quite the contrary from your first post) you better browse somewhere else before we delete your useless and disturbing posts

[StephenCastlecrag]

I wonder whether you have stopped Tenofovir again? If yes, that will explain  the increase in  your hbvdna viral load. The high ALT can be due to your hbv (because you have stopped Tenofovir) and/or due to your fatty liver.

You cannot stop Tenofovir just because your viral load is going down or undetectable, because it is Tenofovir that is keeping the viral load down, but it does not eliminate the underlying amount of cccDNA in your liver that is producing the viral load.

[stef2011]

change lab, this result is useless, you need hbsag quantitative not >250iu/ml.why do they use old kits without dilution?ask for money back and correct test with dilution and post hbsag quantity

if your hbvdna is really about 5000iu/ml you have to add on entecavir, also be sure you take tdf every day and it is viread and not a fake pill, non response to tdf is after many years is 1% so it is difficult to fall in this 1%, anyway hbvdna will become und on tdf+etv

after you know hbsag quant in iu/ml and hbv genotype you can also consider:
tdf+etv+pegintf
or tdf plus pegintf

[hepa114]

HBsAg is Reactive Value >250 IU/mL

missing in previous report

[hepa114]

some correction... ignore previous report.

Hello Stephen/Stefano

recently i have done my full checkup again after continuing on tenofovir from last three years.

report on 21/01/2013

HBeAb : Positive
HBeAg : Negative
HBV DNA Quantitative by TAQ MAN : 677 IU/ML
ALT : 30
AST : 26

on 18/02/2014
HBV DNA Quantitative by TAQ MAN : 5430 IU/ML
HBeAb : Positive 0.14 (<1 Reactive)
HBeAg : Negative 0.40 (<1 Non-Reactive)
HBsAb (Quant) : Negative 0.20 mIU/mL (250 IU/mL
ALT : 78.2
AST : 51.8

Ultrasound : Liver: Both lobes of liver are normal in size with increased echotexture. No focal lesion is seen. there is no IHBR dilation.
impression : moderate fatty liver

Lipid profile: cholesterol total : 240.5 mg/dl
Triglycerides : 397.5 mg'/dl (40-150)
HDL : 33.4 mg/dl (35-80)
LDL : 127.6 mg/dl
VLDL : 79.5

ok, after seeing above results could you please pass you comment? my question are why the DNA viral load got increased from 677 to 5430, also ALT/AST is also on higher side? is it possible to conver HBsAG from positive to negative?
what does fatty liver mean? does it is because of i have high cholesterol, and because of this ALT/AST are also high?
should i continue to take tenofovir, last time when i meet with my Dr 1 year back he advice me (seeing viral load of 677) that you be on med for another 6 month if your DNA become undetectable and HBsAG goes negative you can stop the tenofovir otherwise also stop it as it will not help further and did not advice any other medicine.

could you please suggest what should be my next step?

thanks is advance...

[hepa114]

Hello Stephen/Stefano

recently i have done my full checkup again after continuing on tenofovir from last three years.

report on 21/01/2013

HBeAb : Positive
HBeAg : Negative
HBV DNA Quantitative by TAQ MAN : 677 IU/ML
ALT : 30
AST : 26

on 18/02/2014
HBV DNA Quantitative by TAQ MAN : 5430 IU/ML
HBeAb : Positive 0.14 (<1 Reactive)
HBeAg : Negative 0.40 (<1 Non-Reactive)
HBsAb (Quant) : Negative 0.20 mIU/mL (250 IU/mL
ALT : 78.2
AST : 51.8

Ultrasound : Liver: Both lobes of liver are normal in size with increased echotexture. No focal lesion is seen. there is no IHBR dilation.
impression : moderate fatty liver

Lipid profile: cholesterol total : 240.5 mg/dl
Triglycerides : 397.5 mg'/dl (40-150)
HDL : 33.4 mg/dl (35-80)
LDL : 127.6 mg/dl
VLDL : 79.5

ok, after seeing above results could you please pass you comment? my question are why the DNA viral load got increased from 677 to 5430, also ALT/AST is also on higher side? is it possible to conver HBsAG from positive to negative?
what does fatty liver mean? does it is because of i have high cholesterol, and because of this ALT/AST are also high?
should i continue to take tenofovir, last time when i meet with my Dr 1 year back he advice me (seeing viral load of 677) that you be on med for another 6 month if your DNA become undetectable and HBsAG goes negative you can stop the tenofovir otherwise also stop it as it will not help further and did not advice any other medicine.

could you please suggest what should be my next step?

thanks is advance...
  

[hepa114]

Hello Stephen/Stefano

Thanks for your reply... from your ans looks like first I need to make HVB DNA undetectable and second wait until a cure for hbv comes out... good enough!

but what about antivirals resistance? after sometime doesn't my body shows resistance against antivirals I am taking and tdf will no longer works on my body?

also what if after some time my HBeAg become -iv and HBsAg will also be negative (although I have not checked HBsAg yet and hoping once HBeAg comes non-reactive HBsAg will also follow).
with this hope I will continue tdf.

Thanks

[StephenCastlecrag]

One of the conditions for stopping antivirals requires very low or undetectable hbvdna - 7 log 5 is not considered to be low.

My guess is that your tests for HbeAg and HbeAb are qualitative, so the numbers 0.831 and 2.07 are meaningless as far as quantity is concerned.

Generally, if antigen (S or E) levels decrease, it is a good sign. I am not expert enough to tell you that it means:
1. Your are producing less antigens, or
2. Your are producing more antibodies, or
3. your immune system is exerting more control.

Generally, e-antigen  seroconversion requires very low or undetectable viral load.

[stef2011]

short answer: you have cronic hbv and unless you take tenofovir you may risk HCC or cirrhosis during your life, what to do to avoid it?take tenofovir for life until a cure for hbv comes out

tenofovir doesn t cure hbv, is not active against hbv, it only allows to stop liver damage and hopefully never develop HCC or cirrhosis

o you have to take tdf for life, hbvdna und means nothing to hbv cure, it only means you have less liver damage

[hepa114]

Hello Stephen/Stefano/Steven
below are my HBVDNA reports.
on 16/12/2012
HBV DNA (By TAQ MAN) > 170,000,000 IU/ML
on 2104/2012
HBV DNA (By TAQ MAN)  7,00,000 IU/ML

what do you think now after seeing HBV DNA reports? I have already started Tenofovir again? How long it will take for me to reach seroconvertion stage?

also i have one more question :
what does 0.831 or 2.07 number means in above HBeAb and HBeAg reports res.?
if HBeAg number is going down means virus protein level is coming down so virus load as well?
also if HBeAg number is going down means i am generating more antibody to fight with virus?

Thanks in advance. .

[hepa114]

Hello Stephen/Stefano/Steven
below are my HBVDNA reports.
on 16/12/2012
HBV DNA (By TAQ MAN) > 170,000,000 IU/ML
on 2104/2012
HBV DNA (By TAQ MAN)  7,00,000 IU/ML

what do you think now after seeing HBV DNA reports? I have already started Tenofovir again? How long it will take for me to reach seroconvertion stage?

also i have one more question :
what does 0.831 or 2.07 number means in above HBeAb and HBeAg reports res.?
if HBeAg number is going down means virus protein level is coming down so virus load as well?
also if HBeAg number is going down means i am generating more antibody to fight with virus?

Thanks in advance.

[StephenCastlecrag]

It seems Tenofovir has brought down your ALT. Your are positive for both eAg and eAb at the same time. You may seroconvert your eAg to negative and maintain eAb soon. We need your hbvdna to have a better idea.
I don't understand why you have stopped your Tenofovir. Stopping antivrals requires certain conditions to be met and consolidated over at least a year. So unless you have knowledge, I advise you to stop playing doctor. Hbv requires long term management and cannot be switched on/off at your own discretion.