HBeAg non-reactive to reactive

Hi Everybody,

My latest results indicates that my HBeAg turns out to be reactive again. Is this really possible? I don't know if there is an HBeAg mutation that exist. What does this result implicates? Please advise.

12/17/2011 Results: (latest)
Anti-HBs (CMIA)      -  0.00           mIU/ml      non-reactive
HBsAg (CMIA)         -  2145.34                       reactive
Anti-HBe (CMIA)      -  0.66                             reactive
HBeAg (CMIA)         -  29.17                           reactive
SGPT                       -  416.79

8/27/2011 Results:
Anti-HBs (CMIA)      -  0.00           mIU/ml      non-reactive
HBsAg (CMIA)         -  2518.79                       reactive
Anti-HBe (CMIA)      -  0.56                             reactive
HBeAg (CMIA)         -  0.559                           non-reactive
SGPT                       -  37.09

My HBsAg decreases and SGPT exponentially increases, does this mean that there is a response in my immune system with the virus?

[stef2011]

dont worry about hbeag it is meaningless, if hbeag has become active again this is a very good because it means you dont have  precore/bcp mutants or if you have they are still a minority of viral population

this probably means hbv has not escaped your immune system response yet since it is still weak and that you have higher chances of hbv clearance with therapy

i do suggest to start tenofovir for 1-2 years and then add interferon to it for another 96weeks and you ll probably clear hbv or make hbsag so low you can go on to clear it by yourself without drugs

[rusty999]

STop drinking alcohol if you value your life have a healthy life.... HBeAg:REACTIVE =infectious

[kinetix1208]

Please I need some helpful advise on this. Please do share your insights. What does it means being HBeAg non-reactive to reactive again.

[stef2011]

dont worry about hbeag it is meaningless, if hbeag has become active again this is a very good because it means you dont have  precore/bcp mutants or if you have they are still a minority of viral population

this probably means hbv has not escaped your immune system response yet since it is still weak and that you have higher chances of hbv clearance with therapy

i do suggest to start tenofovir for 1-2 years and then add interferon to it for another 96weeks and you ll probably clear hbv or make hbsag so low you can go on to clear it by yourself without drugs

[kinetix1208]

Thanks stef for answering, it's really a great help especially in understanding the situation.And thanks for the recommendation, I'll try to find a doctor who would prescribe me with tenofovir. I read your post that tnf has low to zero sides and has no resistance.

[grmr]

@ kinetix

are you a carrier since birth? have you ever went through any therapy?

[kinetix1208]

No, i'm not a carrier since birth, the last time i donated a clean blood was 2004 as i recall. I found out that i have these disease in 2008, it was already at chronic stage, too late. I have not been in any kind of therapy, just a healthy living. I take a lot of vitamins everyday, vit d3 (6000 IU), c (1500mg), e (800 IU), etc. as posted here in the forum. It's the best thing I can do since i cannot afford any medication continuously. I'd like to try tenofovir as recommended by stef but I'll try to see it first if it fits with my budget.

[HOTH]

kinetix, you said that as far as you know, you did not have HBV from birth and that you last gave blood in 2004 with no issue.  Have you had a blood transfusion or been on drugs to suppress your immune system for medical or non medical reasons?

If those questions are to personal,  please forgive me.  I do not mean to offend.  I only ask because I'm trying to get my head around all of the info. I'm learning about how one gets chronic hbv.

Thanks in advance,
HOTH

[kinetix1208]

No blood transfusion and i didn't take any drugs as i remember. I think it's because when i had this disease i was at my non-healthy lifestyle, and so it gets chronic. I barely ate fruits that time, no exercise, don't get enough sleep, i ate food at fast food restaurants always (no nutrition), no vitamin intake. And that i guess how it becomes chronic, too late when i have noticed it.

[HOTH]

Thanks for getting back to me, Kinetix. Your response is very very helpful.  Your response only confirms that I need to get a better understanding of the information I'm taking in.  I thought that normally all adults clear HBV with no damage unless they 1) got it as a child  2) received an infected blood transfusion 3) had a suppressed immune systems do to medical drugs or HIV.  The lifestyle you described is the lifestyle of the average American.  

I believe the static I read said that 90% of people clear HBV without having any symptoms whatsoever.  I now see that that 10% should also include people outside of the criteria I mentioned.  

Thanks again,
HOTH

[kinetix1208]

Below are my latest results:

12/17/2011 Results:                                                                  COV
Anti-HBs (CMIA)      -  0.00           mIU/ml      non-reactive        10.0
HBsAg (CMIA)         -  2145.34                       reactive                1.0
Anti-HBe (CMIA)      -  0.66                             reactive                1.0
HBeAg (CMIA)         -  29.17                           reactive                1.0
SGPT                       -  416.79          U/L                                  10 - 41

1/16/2012 Results:                                                                    COV
Anti-HBs (CMIA)      -  0.00           mIU/ml      non-reactive         10.0
HBsAg (CMIA)         -  1976.07                       reactive                  1.0
Anti-HBe (CMIA)      -  2.01                             non-reactive           1.0
HBeAg (CMIA)         -  69.95                           reactive                  1.0
SGPT                       -  305.51          U/L                                   10 - 41
Anti-HBc IgM            -  0.74                            non-reactive            1.0
Anti-HBc Total          - 13.88                           reactive                   1.0

Remarks: Anti-HBe count below cut-off value is considered reactive.
Specimen - Slightly icteric sample

HBsAg and SGPT went down a little bit, HBeAg went up. I'm a bit confused with the Anti-HBe results since the remarks says that it is now non-reactive. I'll confirm this tomorrow in the laboratory.

Is this possible? Anti-HBe goes from reactive to non-reactive?

Also, it says that the specimen is slightly icteric. Am i getting into the state of jaundice?

Is my situation worsening?

[kinetix1208]

Any comment on the above post?

[jhon83]

Hi, I have a HBeAg reactive, my result is 199.1, ref.value is 1, what should I do to have a HBeAg non-reactive. ty