Despite this being an old thread, I wonder if there's a more recent update? Would love to learn more.
Hi, any news? Did your HBsAg turned to negative?
Hi-
Your serology is consistent with a carrier known as a heterotypic state. Often times when people develop HepB S Ab in response to an infection it is protective. About 10% of the time, someone will develop an Surface Ab and have surface Ag persist. Some hypothesize that this may represent an antibody response that is ineffective in clearing the infection.
However, the good news is that you are completely undetectable in terms of DNA and also have a negative e ag which are both good prognostic indicators. Best of luck!
Thanks Steven. I was hoping the same thing... oh well, what's another six month wait? I am used to it by now... NOT. :-)
Dave
D'oh...I was pulling for you to the the lucky few who seroconvert to HBsAb positive and HBsAg negative. But least your ALT and DNA looks good. Good luck!
Got my latest lab results today. This is eleven months after stopping Peg, and ten months being on Tenofovir.
Liver panel, all competely normal and in range, including ALT and AST.
ALT 44 range 9-60
AST 26 range 10-40
HBV DNA PCR quant <100 (aka undetectable, says the doc)
HBeAg non-reactive
HBeAb reactive
HBsAg reactive (still)
HBsAb also reactive
So it looks like I am doing just fine, although I sure would like to see that HBsAg go non-reactive (wouldn't we all?). Unfortunately we didn't do titers on the HBsAb this time, I wish we had.
Back to "wait and see" mode for another six months.
My doc thought last spring that it might have been the combination of being loaded full of interferon for 8 moths and then slamming my system with tenofovir that caused the "e" seroconversion, and the subsequent chain of events (loss of DNA, first appearance of sAb). He was only expecting the peg to drop the DNA - was very surprised to see the "e" conversion and the rest happen so quickly. I guess we'll know more about my status in a couple of weeks.
My doctor didn't order biopsy or other tests because he said it won't chance course of treatment. I will consider additonal test if there is a new reason for it.
Insurance companies could be such bastards sometimes. Sorry that you had to stop PEG especially if you tolerated it well. I hope you do well with the antivirals. I have a feeling PEG abd tenofovir will be in my future. We'll see. Good luck to us HepB people.
Thanks Steven.
I wonder if it's worth asking for a biopsy, a genotype, or any other kind of tests; I want to rule out a mutant.
I did fine on the Peg actually; first two weeks were kind of rough - flu like symptoms, exhausted, headaches, etc - but after that, I seemed to get used to it and eventually didn't really notice it other than injection site soreness. All the time I was on it, my DNA was dropping gradually - about a log every three months - but not fast enough for the insurance company, who eventually stopped approving it. That's when my doc switched me to anti-virals.
Okay...okay...we will revisit that commission issue...LOL.
Seriously, thanks for helping to bump up the HepB post. HepB needs community support too :)
While rare it could happen (being both positive). If your HBsAg stays positive with undectable DNA it could that your treatment helped you reached an inactive carrier status. But as long as your HBsAg is positive, there is a chance to reactivation to an active disease. It would be interesting to see if you sustain your status without the meds. At any rate, your treatment seem to be going well. Congrats!
When they test your for HBsAb, they are testing for a specific protein. Sometimes a protein with a very similiar characteristic to HBsAb register this marker to be positive but it is not the exact antibody to the HBsAg. In this case, you still have HepB. It's kinda like the key to your expensive and sensitive lock. When you make a copy of the key. Although the key looks the same, it may not open the lock due to a very slight difference to one of the teeths not visible to the naked eye. I know of a person who also tested positive for both and this was how his doctor explained it to him. Share this with your doctor and see what your doctor say. Actually let me know what your doctor say.
Also how did you do on Pegasys? How did you tolerate it?
StevenNY is our Resident HepB god of knowledge. LOL!
He'll be along sometime in the next 2 days. Hang in there.
Meki