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HDV markers
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HDV markers

What means the result "Anti HDV IgM = negative" ?

I know that the correct test is Anti HDV IgG total, but I will have this result in 2 weeks, until then I only have the Anti HDV IgM = negative result and from the  information that I found on internet are contradictory somehow, so maybe someone know a simple answer to this questions.
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Avatar_m_tn
found some answer on http://www.cpmc.org/advanced/liver/patients/topics/hepd.html

Coinfection with Hepatitis B and D: the serologic course of HDV infection varies depending on whether the virus is acquired as a coinfection with HBV or as a superinfection of a person with chronic HBV infection. In most persons with HBV-HDV coinfection, both IgM antibody to HDV (anti-HDV) and IgG anti-HDV are detectable during the course of infection. However, in about 15% of patients, the only evidence of HDV infection may be the detection of either IgM anti-HDV alone during the early acute period of illness or IgG anti-HDV alone during convalescence.

Supercoinfection with Hepatitis B and D: Typical Serologic Course: In patients with chronic HBV infection who are superinfected with HDV, several characteristic serologic features generally occur, including: The concentration of HBsAg declines at the time HDAg appears in the serum; HDAg and HDV RNA remain detectable in the serum because chronic HDV infection generally occurs in most patients with HDV superinfection, unlike the case with coinfection; High concentration of both IgM and IgG anti-HDV are detectable, which persist indefinitely.

So, this can be translated that "Anti HDV IgM = negative" means that no Supercoinfection with Hepatitis B and D exist but to eliminate also Coinfection is need that IgG anti-HDV to be tested.
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Avatar_m_tn
also http://www.kenes.com/easl2010/posters/Abstract209.htm spoke about the correlation of Anti-HDV-IgM with disease activity
"Conclusions: Anti-HDV-IgM levels correlate with disease activity in patients with delta hepatitis and may indicate stronger immune responses against HDV. Anti-HDV-IgM ODs decline during successful PegIFNa-based treatment and high baseline values may be predictive for treatment response. "

what Anti-HDV-IgM ODs means ? (i have the impression that Anti-HDV-IgM and Anti-HDV-IgM ODs are different)
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Avatar_m_tn
also for hepatitis markers a good link is:
http://www.authorstream.com/Presentation/rajhrv-424189-hepatitis-markers-serology-education-ppt-powerpoint/

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Avatar_m_tn
in:
http://books.google.ro/books?id=lrPX8C4p90QC&pg=PA700&lpg=PA700&dq=ANTI-HDV-IGM&source=bl&ots=-p8lZHjY8s&sig=73LL5z01XOdET444LNPq73859fo&hl=ro&ei=7QBmTt3qGYaG4gSl9symCg&sa=X&oi=book_result&ct=result&resnum=6&ved=0CDMQ6AEwBTgK#v=onepage&q=ANTI-HDV-IGM&f=false

it is stat that "in a self limited HBV/HDV co-infection Anti-HDV-IgM antibodies frequently represent the only marker of infection"

What is self limited HBV/HDV co-infection ?

I'm still puzzled regarding the Anti-HDV-IgM test result.
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Avatar_m_tn

anti hdv igm
anti hdv igg
hdv rna

thse are all the tests to do so no worries
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