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HDV

Got a call from my hepatologist today saying that my anti-delta test came back equivocal. This is the second time he tested and it came back equivocal. He then states I'm sure your just a false positive but we will check for the genotype. He goes on to say its very rare for me to acquire hdv because I'm asian and we're in the U.S.

Can someone explain why it keeps coming back as equivocal and then for him to state that he thinks I'm just a false positive, but then want to check for genotype?? I feel like he's almost holding back on giving me bad news that he knows. Maybe I'm just being a pessimistic, but I feel I just keep getting hit with more bad news.
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Avatar_m_tn
acquire hdv because I'm asian and we're in the U.S.

hdv is superinfectious for hbv carriers, just going to the dentist or medical exams you may get infected by saliva in the air from the previous person if carrier.....

hdv is rare because only hbvers can get it but superinfectious, we have to be very carefull on healthcare settings

as to your case i do hope it is a flase positive but just check hdv-rna if hdvab igm got positive or as doc said genotype

in case of hdv positive there are clinical case reports of getting rid of both hbv and hdv by interferon+tnf+ftc combo (interferon+truvada)
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Avatar_f_tn
Thanks for the reply

I guess you can never be to careful nowadays even with healthcare protocols.

These clinical case reports, isn't it only if your viral load is low or hbeag is neg? I'm still in the immune tolerant stage with viral load in the millions...
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Avatar_m_tn

the guys were hbeag positive but not in immune tollerant stage.

so you have hbvdna in millions and normal alt?
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Avatar_f_tn
Yes
May 2010=344 million copies
Oct 2010=244 million copies
May 2011=162 million copies

He said my ALT(11) and AST(14) are on the low side..

Is this a good thing that my hbvdna is lowering, although not by much ?
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Avatar_m_tn

you are perfectly healthy and i have never heard of immune tollerant hbv+hdv superinfection so as long as alt are totally normal like less than 20 i dont think hdv is there and any therapy is needed
just recheck hdv by genotype or hdvrna
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Avatar_f_tn
please tell me i have hdv and hbv with compensated cirhossis taking tenofovir am i right at meds?
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Avatar_m_tn
for hbv yes, but only for hbv because tdf is active on hbv only

the best therapy is tdf and then peginterferon add on.peginterferon is active on both hbv and hdv

it is not good to go directly for both drugs combo because hbv is able to suppress interferon.it is best to weaken hbv by tdf first
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Avatar_f_tn
do you know anyone who regressed their cirhosis being hdv hbv both?
also tdf will supress hbv in a long time will i decompensate till then?
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Avatar_f_tn
im sorry i dont have a lot of information also just new to this forum
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