Hello all. Happy holidays and wishing you all a healthy and happy new year to come. It has been some time. Are the regulars from my time still here? It's good to see stef still going strong here. Stef sounds like a scientist now :) Nothing really new on my end. With health care the way it is in the US, the focus is on "treating" with anitvirals. So no big changes. Still HBsAg positive and on antivirals. Did anyone successfully seroconverted to HBsAg - and HBsAb + ?
hi steven, good to see you here again, happy holidays
keep an eye about pegintf add on long term antivirals responders.hbv cure might simply be there among these trials
also good to keep an eye on:
keeping high vit d 25oh and high gcmaf levels on patients with vdr receptors bb/FF, Bb/FF, bb/Ff during peginterferon.my guess is this can boost pegintf response and make peg sides much lighter.
vdr BB/ff does not respond to vit d, gcmaf and a study on pegintf for hcv link this to poor response.this genotype is rare
there are some members who cleared on peginterferon mono when hbsag was less than 500iu/ml (otan and maybe some other member i dont remember)
and some members close to clear who had peginterferon add on to long term use of antivirals
it is also good that all those clearing had very light sides or almost no sides from peg
Thanks Stef for the info. But it's always helpful to have your pointers to the latest research. I tried to keep up on recent developments in HBV but with the way health care works in the US, it's hard for us patient to decide on the course of treatment because everything is about cost control. To play for out of pocket is just not realistic in US healthcare. Quantatative HBsAg is still not done when I am. It was frustrating so I come to accept I will have to live HBV for sometime.
dxpress: At a certain point, I decided not to let HBV run my life so I took a step back. It was made easy since Stef was here...haha. When I came to this forum in my time, there was nothing. I was reading the C forum for some info. So all should know that they are very lucky to have people like Stef here. I had always hoped that people who were helped here would stay a bit to help the next person. So when you learn you have chronic HBV, it's hard.
stories of hbv clearance or hbsag almost cleared (just a matter of time when values like 10-20iu/ml are reached), there may be some other members i dont remember.
all these stories are interesting because pegintf response lies in there:
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