a chronic patient star with HBeAg positive (Immune tolerance phase and Immune clearance phase) and after that go in HBeAg negative (low replication phase or immune escape phase).
usually, it is say that HBeAg are more responsive to the treatments maybe becuse also the immune system is working in the same time (Immune clearance phase). On HbeAg negative we have the risk of mutation, some mutation can be done durin natural way but most off all are do to the actual drugs (if a permanent mutation is made then HBeAg - negative and HBV DNA bigger the 2000 UI/ml - immune escape phase) but on the other hand usually most of the patients HBeAg negative will stay in low replication phase and ususaly they don't need medication, they need only to be monitored and have 1% chance of seroconversion s
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