none they are out of guidelines from many years, they just make virus mutations which cannot be treated and worsen hbv infection very very much
the only drugs as firstline treatment for hbv are:
tenofovir, most potent no resistance and no mutations
interferon no mutations
entecavir, 1.2% resistance only if there are no zeffix mutants, with prior use of zeffix cant be used
cure of hbv is interferon+tenofofvir, all drugs monotherapy dont clear hbv
i think zeffix and heaspera re out of guidelines since 2009, many doctors and researchers knew they were useless since their first approval around 2000 and i was lucky to know one who saved me from use of those drugs since 2000
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