On 26 aug I tested positive for HBsAg. Had a viral load test done and my DNA was 13,049 copies/mL and 2,246 IU/mL.
Went to another lab and was asked to do a Hep B profile on 9th sept these were the results;
HBsAg value 797.30 IU/ML
HBsAb value 0 on a scale of 0-10
Hep C antibody negative
I am confused, what is the difference between the hbsag value and the DNA? And give the results above, am I a threat to society? Am I a candidate for treatment? Is my body fighting or not?
first of all hbsag and hbvdna has almost nothing to share.
hbsag reflects infected cells in the liver, immune system response to hbv if any, hbv inside liver cells (cccdna).hbsag is also the only test that can predict response to therapy and chances to clear hbv on pegintf
hbvdna with hbsag quant available and fibroscan is really of little value compared to the use in the past.it shows virions in the general circulation but it is of little value because even if undetactable in the blood virions are present inside the liver and inside liver cells with little difference between undetactable in blood and few thousands.it is used as a measure of antiviral efficacy during treatment and combined with hbsag it is very useful while used alone is of no use for hbv cure (i mean cure, not just maintenance)
as to your hbsag you are very very lucky, it is very low and it reflects and active immune response and high chance to clear hbv on pegintf.you have to check what your hbv genotype is and tart peginterferon treatment, antivirals are almost useless in your case because hbvdna is already very low
check also our vitamin d thread and hbv seroclearance on high levels of vitd25oh.before treatment check your vitd25oh and if less than 80-100ng/ml start taking 10.000iu of d3 before pegintf.a high vitd25oh level boosts response to pegintf while a deficient vitd give pegintf non response
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