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Hello all

I have started inf+tnf treatment 16 weeks ago. Before treatment the lab results were: HbsAg quantitative 40.000 IU, HBV DNA 300 millions IU/ml, TGP 100.

After 14 weeks of treatment the results are: HbsAg quantitative 30.000 IU, HBV DNA 6000 IU, TGP 47, pallets count is  low 99.000

Is there a reason to continue the treatment considering the result after 14 weeks of treatment?
What is the best strategy for me now?
The dr recommended to continue with 90 mcg for this weeks because of pallets and if they rise i will go back to 180 mcg of inf.

Thx all.
12 Comments Post a Comment
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Avatar_m_tn
i have platelets lower than yours adn take 135mcg shots.. go on you seem to be responding as hbs went down..
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Avatar_m_tn
are you EAG-ve or +ve?
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Avatar_m_tn
I go on then and see how it goes. I'am EAG+ve
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Avatar_m_tn
as i am.. but you should reduce dose only if platelette are <50000 or so.. by the way how old are you?
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Avatar_m_tn
22 years old
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Avatar_m_tn

wow big response on hbsag definitely continue with this dose, plts get low when in the 25000 range, at 99000 you are ok

check or ask in hcv community they are very experienced with intf and heavy sides since on hcv intf has many many more sides than on hbv, instead of lowering intf dose they take a drug to increase plts

i think only extremely low neutrophils cannot be managed by drugs and lowering dose is necessary
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Avatar_m_tn

neupogen drug for low neutrophils and Eltrombopag for low plts during intf

http://www.pharmastar.it/index.html?cat=5&id=7939

use chrome to translate the link from italian to english

i wonder why grmr wasn t offered these drugs instead of intf dose lowering
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Avatar_m_tn
Thx Stef for sharing your info and knowledge.
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Avatar_m_tn
I'm at the end of treatment (48 weeks) that was sponsored in a study by Gilead. After the medication stops I will have to make blood analysis every 2 weeks till December to see my trends of blood analysis. If the trends are bad they will give me for more 2.5 years Viread.

The treatment was inf plus Viread until week 20 then just Viread until 48 week.

My results at the week 32 are: normal AST 22 and ALT 28, HBV DNA und, HbsAg quantitative 24.000 IU.

I don't have the results for the 40 and 48 weeks but the treatment is at the end.

I would like to ask your opinions about continuing with Viread on my own.

What do you think is the best option for me considering my results.
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Avatar_m_tn
that design is a failure from the begining, the correct thing is tdf for at least 3 years and when hbsag is less than 7000iu/ml pegintf add on

pegintf can t work on such high hbsag unless you are hbeag pos
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Avatar_m_tn
I'am still Hbe positive. Sorry I forgot to mention. The idea is if I should buy Viread by my own instead of waiting to be provided by gilead if my blood work goes bad?
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Avatar_m_tn
It woul be wyse tocontinue with Viread. Thankyou Stef.
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