Help me with Hep b results

[charan123]

Dear all,

I've recieved my results today and as below . Please help me to understand this ...

                                                                                RESULT                    REF RANGE

Hepatitis B core antibody ( Anti - HBC )                 10.93                          < 1.00
Total, serum ( CMIA )

Hepatitis B Surface antigen ; hbsag                       14284.08 IU/ML
quantitative ( CMIA )

Hepatitis B core antibody ( ANTI-HBC ) IGM           0.06                            <1.00
SERUM

Hepatitis Be antibody ( Anti -HBe ), serum               0.90                            < 0.90
( CMIA )

I have done only above 4 tests please let me know if I need to test any other

[StephenCastlecrag]

No. Please read my previous posts.

[charan123]

Thanks Stephen. Do I need to take antivaral tablets or any to keep myself in this control phase ?

[StephenCastlecrag]

I suggest you keep monitoring your hbvdna and ALT every 6 months. As your
hbvdna is < 2000 iu/ml and your ALT is about normal, no treatment is needed according to most guidelines.

[charan123]

Hi Stephen,

I got my HBV DNA results today and it's as below ...Please let me know my condition..


Sample for HBV DNA is showing 433 IU/ml = 2520 copies /ml
Exponential value 2.5 E+03
Log Value ( Copies/ml ) 3.40

Thank you
Charan

[StephenCastlecrag]

So your liver functions panel is normal, including your ALT. So far so good. Now wait for your hbvdna result.I don't see any need for UGI ENDOSCOPY - this is looking down your throat to look for varices in patients with diagnosed cirrhosis.

[charan123]

Dear Stephen and all ...

I got few test results today and still am waiting for FDV DNA test . Please check my results and let me know how is my condition


ALPHA FETRO PROTIEN ( AFT ) test

AFT                3.1 ng/ml  ( ref range < 7 ng/ml )


Liver function test ( LFT )

SGPT ( ALT )       35  U/L             ( Ref range 0 - 40 )
SGOT ( AST )       26  U/L             ( ref range UPTO 40 )
TOTAL PROTIENS     7.4 GM/DL ( ref range 6 - 8 )
ALBUMIN            4.5 GM/DL         ( ref range 3.5 - 5.2 )
globulin           2.9 gm/dl                 ( ref range 2.3 - 3.5 )
TOTAL BILIRUBIN    0.9 MG/DL    ( ref range 0.3 - 1.2 )
DIRECT BILIRUBIN   0.3 MG/DL    ( ref range upto 0.2 )
INDIRECT BILIRUBIN 0.6 MG/DL

Hematology Hemogram test
Everything is normal but Mild eosinophilia is noted


        

[StephenCastlecrag]

Tests 3 LFT (liver function test, this will include ALT), 6 AFP (a marker for liver cancer), and 7 HBVDNA  seem reasonable to me. Depending on the results from these 3 tests, the other tests may be considered. You have to ask your doctor why all these tests are needed.

I really think you should take one step at a time. HbsAg level is just of one of many factors to take into consideration in what treatment is appropriate.

[charan123]

Ok Stephen ..I understand
I met doctor today and he asked me to get few tests  as below

1) HEMOGRAM
2) PROTHROMBIN TIME
3) LFT
4) US ABDOMEN
5) UGI ENDOSCOPY
6) AFP
7) HBV DNA QUANTITATIVE

what are these tests means ? do you think any medcines work if HBSAG is 14500 ui/ml ? my doctor said we just need to look only HBV DNA levels instead of HBSag ?

[StephenCastlecrag]

Read carefully. Whether you are in the immune control phase needs to be confirmed by your viral load and ALT. No need to repeat the other tests.

You may stay in the immune control phase for a long time or you may transit to the immune escape (your virus is active again due to mutations) phase. We don't know. That is why, you will need regular check up. Go to see a liver specialist and be looked after by him/her.

[charan123]

Sure Stephen . Do you want me to repeat all the tests along with HBVDNA and ALT ?

You mentioned that am in immune phase , It means virus will get activate anytime ?

[StephenCastlecrag]

Hepatitis B is a chronic disease, so it is highly unlikely that you will die immediately - chronic means long time. But it does mean you will need to monitor your disease, and to treat when it is necessary.

I am going to repeat just one more time. You need VIRAL LOAD(HBVDNA) AND ALT TESTED.

[charan123]

Thanks a lot stephen. God bless you ......

Yes my HbeAb is positive as you said . But you mention that am still in chronic what it mean ? am still in danger ...?

Please let me know what are the tests that I need to perform ?

[StephenCastlecrag]

So it seems you are HbeAb positive. This usually means you are in immune control (disease is inactive) phase. This should be confirmed by your viral load and ALT. If you are indeed in the immune control phase, you will not be very infectious to others. But you are still chronic. So get your viral load and ALT measured.

[charan123]

I am in tension so please don't mind if am sending duplicate message

my result is 0.90 ( Index value ) and the interpretation is as below

Index Value  interpretation    Comments
> 1.00          Non Reactive      Not decetive
< = 1.00        Reactive             resolution of infectious state
.

God bless you

[charan123]

Please see only this message and last message as there was some typo mistake in my another post

Test Name                     Result   units    ref range

Hepatitis Be antibody
( Anti -HBe ), serum        0.90     index     1.00          

[charan123]

Please check below for interpreation

interpretation
Index Value  interpretation    Comments
> 1.00          Non Reactive      Not decetive
< = 1.00        Reactive             resolution of infectious state

[StephenCastlecrag]

I don't think your interpretation about your HBeAb result is necessary correct. Generally, for antigen, if it is below a reference level, then is is non-reactive. But this is not necessary true for antibody test. It is complicated, so your Lab should provide the interpretation.

HBsAg is just a protein, it is non-infectious and it cannot kill you. Its quantity in the blood gives a clue to the degree of infection in your liver. As I said before, what does high and low mean depends on other information.

You need hbvdna and ALT tests.

[charan123]

Thanks a ton stephen.

I think my HbeAb result is non reactive as per below ( Corrected ) .

Hepatitis Be antibody
( Anti -HBe ), serum               0.90                            < 1.0
( CMIA )

If HbsAg is high means , does medicines works for me ? will I die soon ?
I don't have any symptoms yet other than black stool and yellow urine

what are the other tests that I need to get ? Please help me to understand

[StephenCastlecrag]

It seems you are chronic. I can't interpret your HbeAb result, what does the Lab report says: positive or negative? It would be helpful to know your viral load (hbvdna) and ALT.

Your qHBsAg level is high but its significance can only be assessed together with other information.

[charan123]

Can any one answer please ? Is HBsAG is very high ?