Aa
Hep B Results
Hello everyone I was diagnosed in May with Hep B my results are below
I have read a lot of the topics on this forum and find it quite amazing how much information is shared
Viral Load 18500 iu/ml
ALT is 49
HBSAg + ( in US) I am pushing to get this in quantitative
HBSAb -
HBCoreAb +
HB Core IGM -
HB Core IGG +
HBEAg -
HBEAb +
Hepascore .33 (normal range)
Ultrasound - normal
I am currently taking
Vitamin D3 10,000 iu/ml
Spirulina
Chlorella
Milk Thistle
I have another set of blood draws next month which will include genotype and hopefully surface antigen in quantitative..
I spoke with my GI/Hep doc and she says based on my data that I'm not quite at the level for treatment yet bit that I am close if the Viral load goes up past 20,000 and my alt climbs she recommended starting Tenefovir I pushed her about the surface antigen clearing and that my understanding is that Tenefovir alone would not accomplish this but that using interferon could depending on my sag level. She said she didn't recommend the interferon because of the possible sides which I told her I would deal with if necessary to clear this virus.... Thoughts comments insights especially from stef would be appreciated!
I have read a lot of the topics on this forum and find it quite amazing how much information is shared
Viral Load 18500 iu/ml
ALT is 49
HBSAg + ( in US) I am pushing to get this in quantitative
HBSAb -
HBCoreAb +
HB Core IGM -
HB Core IGG +
HBEAg -
HBEAb +
Hepascore .33 (normal range)
Ultrasound - normal
I am currently taking
Vitamin D3 10,000 iu/ml
Spirulina
Chlorella
Milk Thistle
I have another set of blood draws next month which will include genotype and hopefully surface antigen in quantitative..
I spoke with my GI/Hep doc and she says based on my data that I'm not quite at the level for treatment yet bit that I am close if the Viral load goes up past 20,000 and my alt climbs she recommended starting Tenefovir I pushed her about the surface antigen clearing and that my understanding is that Tenefovir alone would not accomplish this but that using interferon could depending on my sag level. She said she didn't recommend the interferon because of the possible sides which I told her I would deal with if necessary to clear this virus.... Thoughts comments insights especially from stef would be appreciated!
Good to see you post! I was wondering where you went to! They didn't have you start any NUCs? I thought you were going for the same clinical trial I was in, for some reason.
I started the Nigella Sativa in February
I started the Argenine in May
I had my liver biposy in late July and the procedure was pretty simple... i was pretty nervous to get it done but it was a breeze.
i have another appointment September 10th so i will see more results then.
I have my regular Physical in October which i am going to have my Vit D checked along with intact PTH
I started the Argenine in May
I had my liver biposy in late July and the procedure was pretty simple... i was pretty nervous to get it done but it was a breeze.
i have another appointment September 10th so i will see more results then.
I have my regular Physical in October which i am going to have my Vit D checked along with intact PTH
when did you start Nigella Sativa - Argenine?
did you notice improvements on tests?
i agree arginine tastes awful, best dose is above 15g per day but it can make nausea/diarrhea so it is best to rise dose slowly and if any discomfort stay with low dose.i still dont think arginine can make any difference but we better try and see
did you notice improvements on tests?
i agree arginine tastes awful, best dose is above 15g per day but it can make nausea/diarrhea so it is best to rise dose slowly and if any discomfort stay with low dose.i still dont think arginine can make any difference but we better try and see
hello everyone been awhile since my last post... some updates
Liver Biopsy shows 0 Fibrosis
HBV DNA 8000 iu/ml
HBS AB - negative
HBS AB - 1.85iu/ml
However this time around they actually noted there was an Anti body count not enough to be considered immune but better than none i suppose
List of vitamins/suppplements
Milk Thistle 3 x daily
Vitamin D 10000 iu/ daily
Multi Vitamin
Nigella Sativa - 2 teaspoons daily
Argenine - 2 x daily -- this tastes awful !!!!!!
overall i feel really good... still have not experienced any symptoms
i generally run and exercise daily and i have been drinking about 3 litres of water a day
Liver Biopsy shows 0 Fibrosis
HBV DNA 8000 iu/ml
HBS AB - negative
HBS AB - 1.85iu/ml
However this time around they actually noted there was an Anti body count not enough to be considered immune but better than none i suppose
List of vitamins/suppplements
Milk Thistle 3 x daily
Vitamin D 10000 iu/ daily
Multi Vitamin
Nigella Sativa - 2 teaspoons daily
Argenine - 2 x daily -- this tastes awful !!!!!!
overall i feel really good... still have not experienced any symptoms
i generally run and exercise daily and i have been drinking about 3 litres of water a day
Well I am genotype A. I have BCP mutation
BCP A1762T,G1764A
That's all I have for now.. Another ultrasound in December.
BCP A1762T,G1764A
That's all I have for now.. Another ultrasound in December.
The reason why your HBV DNA goes up and down in a small range is because you are e-antigen negative. It means the HBV is replicating slowly and your immune system is controlling the virus.
However, that alone will not clear HBsAg. Maybe you are not a candidate for treatment as yet. But when you are, TDF or IFN is best choice. Good luck.
However, that alone will not clear HBsAg. Maybe you are not a candidate for treatment as yet. But when you are, TDF or IFN is best choice. Good luck.
Yes I thought about being rejected from the trials now because of the criteria.
I have also read that HBV DNA will fluctuate as well. I saw it from original
6000 -> 9000 -> 18,000 now down to 1700
Hopefully it will resolve on its own
I have also read that HBV DNA will fluctuate as well. I saw it from original
6000 -> 9000 -> 18,000 now down to 1700
Hopefully it will resolve on its own
It's good to see your DNA go down, but from what I've been told.. with Chronic cases, you can see the DNA fluctuate like this. It may go down and a few months later, it may go up again. Thankfully, it's a low amount. When mine started to go up and every time I saw an increase of 5 million, I got worried. Then, once it hit 23 million, it went down right before I started the meds and it went down by 5 million.
Might I add that a lower DNA value, may hurt your chances for clinical trials or even for treatment in some cases. I'm not saying try to increase it, obviously you want to see it all down... but just keep that in mind if they reject you on clinical trials and don't get too frustrated. If it keeps going down, be thankful :)
Might I add that a lower DNA value, may hurt your chances for clinical trials or even for treatment in some cases. I'm not saying try to increase it, obviously you want to see it all down... but just keep that in mind if they reject you on clinical trials and don't get too frustrated. If it keeps going down, be thankful :)
I agree I was stunned when I saw the results. Having low DNA replication and normal ALT. was a shock based on my previous results.
I hope the start testing and releasing the labs for HBSAG soon. As a human I would like to be able to make my own decisions and not just take a doctors advice blindly.
Genotype should be in soon and I have another ultrasound set for December.
Regards,
D
I hope the start testing and releasing the labs for HBSAG soon. As a human I would like to be able to make my own decisions and not just take a doctors advice blindly.
Genotype should be in soon and I have another ultrasound set for December.
Regards,
D
that's intersteing , to bad we do not have an HbsAg quant test. your hbvdna is low and still going down without any Alt flare or medications.
Hello Everyone!
Got some labs back today
hBV viral DNA load went down
Jul 18776 iu/ml
Oct 1776 iu/ml
Unfortunately I don't have any HBSAG numbers because I live in the US
All liver enzymes are within normal range
GGT is 18
still waiting on genotype to come back.
I am not on any meds
Got some labs back today
hBV viral DNA load went down
Jul 18776 iu/ml
Oct 1776 iu/ml
Unfortunately I don't have any HBSAG numbers because I live in the US
All liver enzymes are within normal range
GGT is 18
still waiting on genotype to come back.
I am not on any meds
in the acute hbv cases there is cccdna left inside the cells for decades or whole life.infact chemio, steroids or immune suppressing drugs can reactivate a deadly hbv infection in these people if no antiviral is used.so immune system might not be enough for many to clear cccdna
i suppose the combo of these new drugs with nucs and pegintf might resolve this issue but one thing is certain it is best to use these drugs when cccdna is already low by use of years of nucs and peg
i suppose the combo of these new drugs with nucs and pegintf might resolve this issue but one thing is certain it is best to use these drugs when cccdna is already low by use of years of nucs and peg
no this is an observation about these new drugs, with longterm use of nucs and peginterferon we decrease hbsag by decreasing cccdna first, so when hbsag is undetectable there is no cccdna or unmeasurable cccdna left inside the cells
on the contrary these new drugs lower or block hbsag with no activityon cccdna inside the cells.making hbsag und should unblock immune system and then clear cccdna but we dont know for sure, this is not a pathway that happens naturally so it would be best to check immune system is able to clear cccdna from the cells
on the contrary these new drugs lower or block hbsag with no activityon cccdna inside the cells.making hbsag und should unblock immune system and then clear cccdna but we dont know for sure, this is not a pathway that happens naturally so it would be best to check immune system is able to clear cccdna from the cells
How sad so even if we clear HBSAG that doesn't mean we cleared the virus or even we are cured? If cccdna is left in this case :-(
i dont think because we have no data of cured patients on any of the drugs on trial.i also hope they all measure cccdna and not hbsag only since most of these drugs artificially block hbsag
rep9ac s the only one who showed hbsag und and hbsab until now but i would like to see if patients cleared cccdna by a biopsy and if hbsag/hbsab are stable over years with no occult hbv due to cccdna in case it is not cleared
rep9ac s the only one who showed hbsag und and hbsab until now but i would like to see if patients cleared cccdna by a biopsy and if hbsag/hbsab are stable over years with no occult hbv due to cccdna in case it is not cleared
DMach21 if you get a success getting hbsag quantitative in US let me know because I had to travel to Europe to get it and once I start on peginterfron I will have to travel again
Thanks for the reply Steff. What are your thoughts on the clinical trial that is going to combo TDF and Gs-4774?
i dont know why but post is missing lines i wrote
these are the choices according to hbsag level:
hbsag>1000iu/ml tenofovir for few years and then pegintf add on
hbsag<1000iu/ml pegintf , vit d3 and simvastatin if you like to add this too
these are the choices according to hbsag level:
hbsag>1000iu/ml tenofovir for few years and then pegintf add on
hbsag<1000iu/ml pegintf , vit d3 and simvastatin if you like to add this too
tdf is not that bad choice after all, all therapies that are going to be approved require hbvdna und from long time and low hbsag for achieving full potential and clear
so better be in the best status when those drugs will be available and clear in a bit.if this will be in 5-10years probably we are already free of hbv by sequential combo
so better be in the best status when those drugs will be available and clear in a bit.if this will be in 5-10years probably we are already free of hbv by sequential combo
these are the choices according to hbsag level:
hbsag1000iu/ml tenofovir for few years and then pegintf add on
vit d levels which make parathormone 10-20pg/ml may help boost hbsag decline on both tdf and peg.the levels of vit d can be higher than 100ng/ml in that case a doctor monitoring is necessary and a no diary diet needed.we dont know if this works much but we are checking it because vit d suppresses th17 which helps hbv persist and enhance immune system activity.me and a few other members are trying this, for now hbsag is going down but i lll tell all about this when enough time on this to draw conclusions
hbsag1000iu/ml tenofovir for few years and then pegintf add on
vit d levels which make parathormone 10-20pg/ml may help boost hbsag decline on both tdf and peg.the levels of vit d can be higher than 100ng/ml in that case a doctor monitoring is necessary and a no diary diet needed.we dont know if this works much but we are checking it because vit d suppresses th17 which helps hbv persist and enhance immune system activity.me and a few other members are trying this, for now hbsag is going down but i lll tell all about this when enough time on this to draw conclusions
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