Hepatitis B+ Delta virus

[vasile79]

Hello, I'm new here. I was diagnosed with hepatitis B+D in 2006. I received treatment with Pegynterferon Alfa 2A for a year but proved ineffective at the end. Does anyone have any idea what kind of treatment could be effective for this type of hepatitis. I'm already desperate that there is no 100 % effective treatment for this disease.
Blood tests are within normal limits except ALT=250  AST=200. Viral load: DNA VHB=23 IU/mL  and
RNA VHD=27 000 000 IU/mL .
Many thanks

[vasile79]

I've been taking k2 simple not k2mk7. Also Magnesium and Borium as cofactors for vit d3.

[sorte]

Do you take also k2mk7 ? It may help with calcium.

[stef2011]

anyway without an expert doctor monitoring vitd must stay within 100ng/ml and vit d3 dose within 10.000iu

good thing is pth went down so your vdr receptor is working and is not inhibited so much, this also means vit d in tissues is now high and working, just correct it to 100ng/ml and apply diet so that urine gets to normal

[stef2011]

in case ca does not go down by 1 week stay off vit d

were you on a no ca diet, no dairies diet and 2.5L of water?if not this maybe the reason of ca elevation

[stef2011]

first of all you need to make urine ca normal, drink 2.5l of water daily, it has to be water with ca less than 10mg/l, avoid anything with dairies

recheck urine ca weekly so we know it gets normalized and also check creatinine and creatinine clearance

vitd25oh is ok around 80-100ng/ml, just a little too high for you at 117ng/ml

also recheck vitd25oh by 4 weeks to see if 10.000iu daily is enough to keep levels, it is best to stay with 10.000 and not 15.000iu until ca is ok

[vasile79]

Hi steff
Please take a look on this:
-23.05.2015-vit d3 level =52 ng/ml
Then I took every 2 weeks an 300 000 ui injection  for 2 months, and pills-15 000 UI every day.So, total was 4 injections.
-12.08.2015-vit d3 level=117 ng/ml ; -calcium urine=440mg (100-300);-calcium blood=9.8mg/dl (8.6-10); -phosphorus blood=3.7mg/dl (2.5-4.5); -phosphorus urine=1284mg (400-1300); -PTH intact=19.4pg/ml (15-65).
I stopped doing D3 injections and taking pills due to high Calcium level.
Can you advice please what to do next, how to keep this good level of Vit D3?

[vasile79]

Hello batuhanb85
How is going your treatment with Lonafarnib? Any improvments ?we are still waiting for this drug release.

[vasile79]

Hi Stef, pls,take a look at this:
-01.05.2015- taken 300 000 UI injection of vit D3
-08.05.2015-after 1 week checked level-36 ng/ml
-15.05.2015-taken 600 000 UI injection vit D3
-23.05.2015-after 1 week checked level-52 ng/ml
Questions: at this level can I do 900 000 UI vit D3 at once? I think after this shot level be around 80-90 ng/ml.And how to maintain high level of vit D3? do you have info how fast the vit D3 level is decreasing in cyrrhotic liver?
I am asking because I have to go abroad for 2-3 months and is good to know how to keep good level of vit D3 and there is no possibility to do an injections and a blood test.

[batuhanb85]

Hi. As far as I know the trial hasn't finished yet. So I can only tell about my results. It was a 12 week treatment. I took 200mg lonafarnib and 100mg ritonavir to increase lonafarnib concentration in blood. After two days, diarrhea started and after two weeks I couldn't even go to work even if I take diphenoxylate for diarrhea. I could only stand for six weeks on 200mg, then my dose reduced to 100mg lonafarnib. Side effects didn't disappear completely, but it was better than 200mg dose.
And the result: In six weeks, my HDV-RNA lowered to 2log copy (6log was my starting viral load per ml) then it raised to 3log and remained same for remaining 6 weeks. 200mg was highly effective but it caused unbearable diarrhea and weight loss, and 100mg was ineffective.

[batuhanb85]

Hi. As far as I know the trial hasn't finished yet. So I can only tell about my results. It was a 12 week treatment. I took 200mg lonafarnib and 100mg ritonavir to increase lonafarnib concentration in blood. After two days, diarrhea started and after two weeks I couldn't even go o work

[vasile79]

Hello batuhanb85
What is your results after Lonafarnib treatment?
Keep us updated pls. I am exactly in your situation: HBV+HDV.

[vasile79]

I have sent yesterday, secon one. Still no answer.

[stef2011]

how long ago did you send email?i received email that they also added new ingredients this year

[vasile79]

Stef, could you tell me pls, how to order Heptech products? On their website says I must get in contact with Heptech physician in my area but in Romania we don't have one. How did you do an order of these products?
I posted 2 questions on their website but no answer.It is look like dead website:):).

[stef2011]

you also need to fix oxidative stress by:
liposomal vit C
liposomal vit glutathione
liposomal resveratrol
liposomal curcumin

fish oil with epa+dha 2.7g

if you can afford heptech protocol is probably the best with vit d3

gcmaf is made by the liver (the liver makes the precursor vitamin binding protein which is very low as well), it is extremely low on damaged livers and under a certain level we die

VBP is also the vitamin D transporter by action of immune cells (B and T cells if i remember correctly) it becomes gcmaf to activate macrophages (but functions are many many others).i used it to regress cirrhosis fast combo with all supplements, vit d3 and antiviral

[stef2011]

replicor is not that dangerous although they dont want to risk with a cirrhotic liver (in your case the most risky is the situation we have now)

i ve posted a study about livers on list for transplant even 400.000iu could not increase vit d3, so the liver damage we have in your case is a lot

you can use 400.000-1.000.000iu shot at this point, what about calcium levels and intact pth?i guess they did not move since also vit d moved very little

[vasile79]

Hello Stef
What does it mean ''gcmaf ''?
I took one injection shut of 150 000 UI of Vit D3 and checked after 1 week after injection.Level increased only 10 ng/ml-(from 27.4 ng/ml to 37.0 ng/ml).
I am thinking to do one more shut of 300 000 UI, what do you think?

[vasile79]

Nobody will take a risk and give to you an drug which is in trial period.

[stef2011]

at this point the only choice (if you can afford it) is use of heptech products, liposomal antioxidants, vit d3 and if this doesn t work gcmaf, as i did for my cirrhosis

the difficult thing in your case is that we have continuous damage whil e in my case virus replication was kept undetectable...despite this todd from heptech was able to keep liver in balance and regress cirrhosis after 4 years of heptech and he was hbv+hcv infected with virus replication

[sorte]

Did you ask them if they can give you that drug out of the trial ?

[vasile79]

I know Stef, but there is no chance to go on trial. I sent  a letter to Replicor and they said they already have their participants and they are on Phase 2 already.So , we have to wait few years.

[stef2011]

have a look on replicor post, looks like it blocks hdv virions too

[stef2011]

Wait 1 week before testing

[melcul]

i suggest to try and reach replicor's trial in Moldavia, maybe you will have a chance and get in for HBV+HDV trial ;

here is the link :

https://clinicaltrials.gov/ct2/show/NCT02233075