Hepatitis B Community
High Level of AST & ALT
About This Community:

This forum is an un-mediated, patient-to-patient forum for questions and support regarding Hepatitis B. Topics in this forum include but are not limited to, Causes, Diagnosis, Family and Relationships, Living With Hepatitis B, Research Updates, Treatment, Success Stories, Support, Symptoms.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

High Level of AST & ALT

Hi,

I'm 29 years Male with chronic Hep B. My HBV DNA levels 2 years back was around 157,000 IU/ML and ALT, AST where under normal limits. Doctor suggested to start the medication with 0.5 mg of entacavir as the DNA levels werr high . Since then my DNA level has reduced to  less than 100 IU/ML for the past 2 years. Also my ALT/AST levels were normal for the same period, but when i got these checked again last month they were high AST -44 U/L ALT -111 U/L. My doctor said that Hep B is not the cause for these high levels of ALT/AST. so he suggested few more tests Lipid profile, ANA-IF,Ferritin and ceruloplasmin. In Lipid profile only HDL cholesterol was low 23 (less< 40) and CHOL/HDL Ratio was high 4.8, ANA was negative, Ferritin was 178.2 ng/mL (range 22 - 322 ng/mL) was normal, ceruloplasmin was normal 0.23 g/L (Rangel 0.2-0.6 g/L).

I don't understand what is the cause for my ALT, AST to be high. Please help.

Thanks
Raj
20 Comments Post a Comment
Blank
Avatar_m_tn
The reason for elevated alt could be fatty liver. Are normal bmi? No obesity? No alcohol abuse, junk food, chemical drinks?
Blank
Avatar_m_tn
The reason for elevated alt could be fatty liver. Are you of normal bmi? No obesity? No alcohol abuse, junk food, chemical drinks?
Blank
Avatar_m_tn
I'm 5feet 5 inch in height with 68Kg Weight. Might be slightly obese but not a significant one i believe.

Let me know your thoughts
Blank
Avatar_m_tn
I used to drink occasionally before 2 years back, but have completely stopped it. I eat occasionally junk food. I did not understand what do you mean by chemical drinks. Please elaborate.

Right now i'm on 0.5mg Entacavir for the past 2 years. Is it possible that medication could have caused this.
Blank
Avatar_m_tn
It is better for the liver to get your bmi to 21-22.
I mean by Chemical drink all industry packed drinks like juices, colas etc. they all contain some chemicals and  sugar.

I think that high alt is due to hbv mainly. Alt flares can happen while on entacavir, retest in 3 months.
Alt = 100 is not too bad, it is probably your immune system killing infected cells. While your liver is ok by Fibroscan, alt = 100 is not a big problem.




Blank
Avatar_m_tn
if you test hbsag quantity in iu/ml (abbott architect) 2 times at about 1-2 months one from the other, you ll see if hbsag is going down...if so you are clearing infected cells and clearing hbv definitively (during this time hbvdna must be und)

if hbsag is stable than is toxic chemicals in food or as said being obese/fatty liver
Blank
Avatar_m_tn
Thanks Stef and Rome

I will get the Fibroscan and Hbsag quantative test done and see how it progresses.

Thanks a lot for your advice.
Blank
Avatar_m_tn
Hi Stef,

Thanks for providing help previously.

Need your guidance on how to progress ahead.

HBV DNA Quantitative(RealTime PCR)
05/9/11 -667197 IU/ml
22/03/12 - 192 IU/ml
11/09/12 - 100 IU/ml
02/07/13- <20 IU/ml
12/06/14 - <20 IU/ml
10/01/15 - Not Detected

HBsAg Quantitative(CMIA)
26/12/14 - 34268 IU/ml
20/02/15 - 16066 IU/ml

ALT
10/09/11 - 24 IU/ml
05/10/11 - 23 IU/ml
20/03/12 - 44 IU/ml
10/09/12 - 48 IU/ml
29/06/13 - 105 IU/ml
19/07/13 - 110 IU/ml
21/08/13 - 111 IU/ml
23/09/13 - 112 IU/ml
21/10/13 - 102 IU/ml
16/12/13 - 120 IU/ml
03/02/14 - 106 IU/ml
08/03/14 - 98 IU/ml
04/06/14 - 78 IU/ml
18/08/14 - 99 IU/ml
09/10/14 - 88 IU/ml
10/01/15 - 92 IU/ml

AST
10/09/11 - 20 IU/ml
05/10/11 - 18.4 IU/ml
20/03/12 - 21 IU/ml
10/09/12 - 23 IU/ml
29/06/13 - 41 IU/ml
19/07/13 - 44 IU/ml
21/08/13 - 44 IU/ml
23/09/13 - 39 IU/ml
21/10/13 - 36 IU/ml
16/12/13 - 44 IU/ml
03/02/14 - 49 IU/ml
08/03/14 - 38 IU/ml
04/06/14 - 30 IU/ml
18/08/14 - 40 IU/ml
09/10/14 - 39 IU/ml
10/01/15 - 36 IU/ml

I haven't got the fibroscan done yet. I'm planning to get it soon.

I recently met my doctor and he suggested that we can give a shot at interferon and there could be a chance that if HBsAg decreases then it might clear.

My ALT and AST were pretty high from quite some time and I saw my HBsAg decreasing even without the interferon. I know there isn't much of an option I have here but to give interferon a chance.

I just wanted to get your thoughts on this and any pre-condition tests to be performed before I go for Interferons.

I'm currently on entacavir 0.5mg since 2011

Thanks again
Blank
Avatar_m_tn
I also got Vitd 25 hydoxy and PTH done recently

PTH(CLIA)
10/1/15 - 92.08 pg/mL

Vitamin D 25 Hydroxy (chemiluminescence)
10/1/15 -  10 nmol/L

Seems like Vit D is way to low and PTH high.

Thanks


Blank
Avatar_m_tn
absolutely start vit d3, you can t live with such levels of vitd and intact pth.that levels of chronic pth makes osteoporosis and immune suppression

take one dose of vit d3 300.000iu and then daily 10.000iu, take also vit k2 mk7

once vit d and pth are: vitd25oh 100ng/ml (or higher if pth stays too high), intact pth at least 20-30pg/ml, it is very good to try pegintf add on
Blank
Avatar_m_tn
if you go over 100ng/ml follow the no dairies diet and 2.5l of low calcium water daily
Blank
Avatar_m_tn
Why he needs to cut calcium (dairies and water low calc) on higher vit D level ? Because calcium absorbtion will be very efficient than ?
Blank
Avatar_m_tn
Because calcium absorbtion will be very efficient than ?

of course, and because most food is too rich of calcium which is not healthy at all.
the main problem of today general health is the extreme deficiency of vit d and vit k2 and the toxic calcium in foods which goes to organs and vessels and not bones, and the toxic drugs which milk is full of
Blank
Avatar_m_tn
yes I know milk nowdays may have antibiotics and other ****, I don't drink milk since a few years, but processed milk like kefir seems to be a bit safer.
how you distinct good calcium from toxic calcium ? good from vegetables, toxic from milk and diairies ?
Blank
Avatar_m_tn
in my coutry milk is very popular and ostheoporozis as well, so there no connection between drinking milk and prefention of this, like people belived years ago.
Blank
Avatar_m_tn
there are even studies linking osteoporosis to milk
Blank
Avatar_m_tn
You think eggs (organic) will be ok ? It's hard to replace diairies so looking for some good protein alternatives. Lots of meat probably wouldn't be good too.
Blank
Avatar_m_tn
Hi Stef,

Doctor gave me Lumia 60k once every week for a month and then 60k once a month.

Is it necessary to get to the required Vit D and PTH levels before going for pegIntf. If that is true then how much time it might take with the above medications.

can you tell me how much vit k2 mk7  i need to take and what would be dosage.

Thanks
Blank
Avatar_m_tn
vit d must be taken daily, weekly not studied and monthly only worsening health
Blank
Avatar_m_tn
vit k 2 mk7 at least 90mcg
Blank
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis B Community Resources
RSS Expert Activity
748543_tn?1371753642
Blank
TMJ/TMJ The Connection Between Teet...
Jan 27 by Hamidreza Nassery , DMD, FICOI, FAGDBlank
469720_tn?1388149949
Blank
Abdominal Aortic Aneurysm-treatable... Blank
Oct 04 by Lee Kirksey, MDBlank
242532_tn?1269553979
Blank
The 3 Essentials to Ending Emotiona...
Sep 18 by Roger Gould, M.D.Blank
Top Hepatitis Answerers
Avatar_m_tn
Blank
stef2011
Italy
9624973_tn?1413019730
Blank
melcul
United Kingdom
Avatar_m_tn
Blank
StephenCastlecrag
Australia
Avatar_m_tn
Blank
terrywillbeok
san francisco, CA
Avatar_m_tn
Blank
luckyman316
Avatar_m_tn
Blank
SafiSifa
Izmir, Turkey