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How can HBSAG be positive and HBV DNA BE UNDETECTED?
From the diagram of a HBV, the HBSAG forms the outer part while the DNA is in the centre. So if HBSAG is detected in the blood how is the HBV DNA not detected in that same blood sample?
The HbsAg in the inactive case is made by integrated HBV DNA inside the hepatocyte genome as opposed to the cccdna (viral genome). It's scary to know how our own liver cell DNA can be modified to produce proteins for a virus. This integration is what is thought to drive cancer in those that don't have cirrhosis cuz it induces genetic instability.
It is possible. It means the virus is not replicating and you are an inactive phase.
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