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IL17 chronic hbv and vitamin d

http://www.xcdsystem.com/icid2014/57.020.html

Increased serum levels of MIF,TGF-β and IL-17 correlate with severity of liver disease and viral replication in chronic HBV infection

Author(s):

J. You1, L. Zhuang2, H. Y. Chen1, X. Feng3, H. Sriplung4, A. Geater4, V. Chongsuvivatwong4, Y. H. Che5, S. J. Ma6, X. L. Zhang1, J. H. Huang7, S. M. Yan8, B. Z. Tang1, R. Y. Zhang1, S. F. Rao1; 1The First Affiliated Hospital of Kunming Medical University, Department of Infectious Diseases, Kunming/CN, 2The Third People’s Hospital of Kunming, Department of Hepatology, Kunming/CN, 3The First Affiliated Hospital of Kunming Medical University, Department of Laboratory Medicine, Kunming/CN, 4Faculty of Medicine, Prince of Songkla University, Epidemiology Unit, Hat Yai, Songkhla/TH, 5The First People’s Hospital of Kunming, Kunming, Department of Medicine, Kunming/CN, 6Haiyuan Medical College, Kunming Medical University, Kunming/CN, 7The Yunnan General Hospital of The Chinese People’s Armed Police Forces, Department of Infectious Diseases, Kunming/CN, 8The Third People’s Hospital of Yunnan Province, Department of Internal Medicine, Kunming/CN

Abstract:

Background: Hepatitis B virus (HBV) infection is a serious health problem worldwide. The pathogenesis of persistent viral infection and hepatitis B is very complex. Both viral factors, as well as the host immune response, have been implicated in the pathogenesis and clinical outcome of HBV infection. But the mechanism has not been clarified. We aimed to investigate the levels of macrophage migration inhibitory factor (MIF), transforming growth factor-β (TGF-β), interleukin-17 (IL-17) and interleukin-10 (IL-10) and their correlation with liver disease and viral replication in patients with chronic HBV infection.
Methods & Materials: One hundred and thirty-eight chronic HBV infected patients [including chronic hepatitis B (CHB), liver cirrhosis (LC), hepatocellular carcinoma (HCC)] were enrolled the study. 30 normal individuals were as control group. Serum levels of MIF, TGF-β, IL-17 and IL-10 were measured using an enzyme-linked immunosorbent assay (ELISA). HBV markers were detected with ELISA. Serum HBV DNA load was assessed with quantitative Real-Time PCR.
Results: Chronic HBV infected patients had significantly increased serum levels of MIF, TGF-β and IL-17, and decreased IL-10 compared with normal individuals (p<0.01, 0.01, 0.001, 0.01, respectively). Univariate analysis showed a similar pattern of the parameters MIF,TGF-β and IL-17 were significantly associated with high viral load, presence of serum hepatitis B e antigen (HBeAg) expression, liver disease severity, and young age at HBV infection, all with p<0.01. In CHB patients, MIF, TGF-β, IL-17 and ALT levels were positively correlated (r=0.725, 0.687, 0.831; p<0.01, 0.05, 0.01, respectively), IL-10 and ALT was negatively correlated (r=-0.562, p=<0.05). .Multivariate analysis showed that the levels of increment of MIF, TGF-β and IL-17 were associated with the increment of HBV DNA load and severity of liver disease.

Conclusion: There is a marked correlation between the concentration of MIF, TGF-β and IL-17 and the severity of liver disease and viral replication. Increased serum levels of MIF, TGF-β and IL-17 correlate positively with the severity of liver disease and active viral replication in chronic HBV infection.
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Avatar universal
25-Hydroxyvitamin D3 Level in Patients with Chronic Viral Hepatitis B
Mohammed Amin Mohammed, Nesreen Moustafa Omar, Amany H. Mansour, Sherin Mohamed Abd El-Aziz and Gamal Othman

Abstract: Vitamin D is an important immune modulator that has an emerging role in inflammatory and metabolic liver diseases. An association has been established between low levels of vitamin D and several adverse health outcomes including upper respiratory and enteric infections, viral hepatitis and HIV infections. It exerts protective effects during infections by up-regulating the expression of cathelicidin and β-defensin 2 in phagocytes and epithelial cells. Thus, vitamin D appears to have systemic antimicrobial effects that may be crucial in a variety of both acute and chronic illnesses. In the current study, 25-hydroxyvitamin D3 (25-OHD3) levels were compared among 75 patients with chronic hepatitis B virus infection (Group I), sixty naturally immunized individuals (Group II) and another sixty age and sex-matched healthy controls. Routine biochemical parameters like hepatitis markers, hepatitis B virus serology, hepatitis B virus DNA, 25-OHD3 and Parathormone levels were measured. Patients in group I had a significantly lower 25-OHD level compared with group II and controls (13.9±4.93 vs. 22.1±6.14 and 23.15±8.28 ng mL-1, respectively p<0.001). In contrast, patients in group I had a higher parathyroid hormone level compared with group II and control group (103.14±24.5 vs. 75.14±23.4 and 74.1±20.15 pg mL-1, respectively p<0.001). Also, 25-OHD levels were inversely correlated with hepatitis B virus DNA levels. The observed diminished 25-OHD levels in patients infected with hepatitis B virus may be an indicator of the viral replication status and portends a poor prognosis.

http://scialert.net/abstract/?doi=jms.2014.192.200
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http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003410

this study describes how hbsag and hbcag promotes these cytokines to persist, i ll read it full later....extremely interesting
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Avatar universal
http://www.ncbi.nlm.nih.gov/pubmed/23448394

http://www.ncbi.nlm.nih.gov/pubmed/21225222

http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003410

other studies on IL17 and hbv, so many available around.just like i am doing it is interesting to see correction of pth to very low normal, low th17,low IL17 and by reflection low IL23 by very high dose vit d3 and improvement of hbv parameters lowering hbsag

i dont think this is potent enough to work alone but in combo with tdf or pegintf i am sure it will give results by 6-12 months
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http://www.redlabs.com/

for those who want to see if il17 lowers taking vit d this test is available at redlabs.com

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http://onlinelibrary.wiley.com/enhanced/doi/10.1111/cen3.12139/

Vitamin D supplementation could limit T helper-17 response in multiple sclerosis

Abstract

Objectives

Low vitamin D and high response of T helper-17 (Th17) are two main risk factors in multiple sclerosis (MS). The purpose of the present study was to investigate whether vitamin D supplementation can reduce Th17 responses and interleukin-17A (IL-17A) production.
Methods

Serum samples of 17 relapsing–remitting MS patients were collected at onset of disease. They were supplemented with 50 000 IU/week vitamin D3 for 6 months. After 6 months, sampling was repeated from the patients. The serum level of 25-hydroxyvitamin D and IL-17A were measured at baseline, and after 6 months using commercially available enzyme-linked immunosorbent assay. Statistical analyses were carried out by Wilcoxon test and Spearman's rho correlation coefficient.
Results

The levels of 25-hydroxyvitamin D were generally deficient (29.4%) and insufficient (47%) in the patients at baseline. The initial IL-17A levels (mean 3.9, standard error 0.28) were significantly decreased after vitamin D supplementation (mean 2.2, standard error 0.18, P < 0.0001). Furthermore, a positive correlation was seen between pre-supplementation IL-17A levels and reduction after supplementation (Spearman's rho = 0.61, P = 0.008).
Conclusion

In the present study, it was shown that vitamin D supplementation could reduce the level of IL-17A in MS patients, and there was an association between these two risk factors in MS disease.
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