After treating with mono entecavir for 5 years, I decided to switch to tenofovir (Pavtino-B made in India) combo for two months.
And recently I have consulted with my doctor to add on interferon Pegnano 180mcg/0.5mL made in Vietnam
Now I am on : INF Pegnano + Tenofovir + Vit D3 10.000IU + Simavastatin 40mg
Here is my status HBV
Date : 19/05/2014
HbsAg : 8462 IU/ml
Anti-hbe+ seroconversion year 4th entecavir
GGT : 38
ASAT : 38
ALAT : 29
Creatine : 12 mg/l
HBV DNA : Undectable since 3 months with Entecavir
Fibros scan : 4.3 kpa
Phophatase Alcaline : 156 UI/L
Alpha Foetoproteine : 2.28 ng/ml
After 6 Injections with interferon starting from 03/06/2014, here is the test result 15/07/2014
HbsAg : 7386 IU/ml
GGT : 75
ASAT : 79
ALAT : 87
Creatine : 12 mg/L
Vitamine D TOtal : 50 ng/ml
I am thinking to increase my dose on Vit D3 to 20.000 IU and Simavastatin to 80mg.
it is best you do creatinine clearance by 24hrs urine collection just to stay on the safe side
in the meantime you can decrease creatinine by baking soda 1 tea spoon daily and then check your ph urine to stay around 6.5-7 this will help kidneys a lot.to check urine ph you can buy small paper test sold at pharmacy
other ways to decrease creatinine are not good during pegintf because they decrease inflammation and this is needed while on peg
if you dont like the taste you can add lemon or maple syrup, it is good to lower acidity (low PH).acidity promotes cancer and makes a lot of work on kidneys that try to balance ph towards alkaline 7
the optimum balance is around 7-7.5 of ph for human body
I go with tenofovir + vitD3 20 000 ui in the morning and simvastatin 80mg at night before bed.
after taking simvastatin I just feel tired and sleepy immediately and wake up with normal mood with no pain at all.
Should I continue with the high dose or more test need to be done to assure the safety ?
Thank Stef2011 for always sharing a good info
I just have a test on creatine this morning cpk seems not elevated.
Creatinine : 12mg/l
Creatine phospho-kinase (CPK) : 90 ui/l
Regarding to baking soda it is likely no one know about it in my town (Phnom Penh capital of cambodia).
also remember to increase vitd before starting treatment, it is best to get some immune action before adding antivirals or peginterferon
my guess on this is:
tenofovir reduces virions fast, this lowers immune activation but if we get vit d high before reducing virions we get more macrophages/phagocytes activity, this may keep more immune activation even when virions will go down when we add nucs or pegintf
same thing with peginterferon, this drug enhances immune activity already in action before we start it, so even in this case it is best to have high vit d before treatment
very very results, this is not even 24 weeks and you already decreased 1log but what really matters is the number if you go less than 500iu/ml hbsag clearance at 48weeks is certain....well actually chances are very very high even now
i really hope we have found how to fasten hbv cure by sequential plus vit d plus sim, however we need a lot of members on this to reach scientific proof
calcium is perfect so you may increase vit d even more than 20.000iu daily if you like although creatinine is still high, did you check creatinine clearance by 24 hrs urine collection?you know blood creatinine test is of very little relevance, was it that elevated even before peg?
i think i will go for a combo if treatment will be needed . i will move to UK next month. and i am thinking if to treat in romania (as its my home and i could come for treatment) or uk, as romania just started to watch hbsAG and they treat by the book ...not personalized treatment, that is very bad for us . what are your suggestions ? as for italy, do you think the prices are acceptable if i would consider it ? i could come by 2,3 months .. ?
Yes Stef my creatinine is upper high level of the range for years.
What can it be indicated with clearance by 24 hrs urine ?
Regarding to the combo I think simvastatin has play a key role in reducing HbsAg because when I start with the first 6 injections Pegnano + sim 40mg the Hbs drop only a thousand which acccount only 12% while my vit D is already 50ng/ml before INF.
After inscreasing sim dosage to 80mg there is a hug drop Hbs started.
What can it be indicated with clearance by 24 hrs urine ?
kidneys function.creatinine in blood is normally high on high body mass or those making gym but creatinine clearance is not affected by this
studyforhope suggested another test i think urine creatinine/albumine ratio, this shows early damage to kidneys cells before function goes down.
in case you have low kidneys function when you stop peg and clear hbsag you may go for fibroguard, liposomal resveratrol and curcumin, glutathione and see if function goes better and of course baking soda.if function is ok it is your normal creatinine values to be 1.3
wow wonderful news at this point we are 99.9% sure you will clear soon since this incredible result in about 24 weeks
i think your hbv cure is based on these facts for sure:
number of years under antiviral before add on, 5 years
use of high dose vit d3
maybe the use of simvastatin but others must confirm this
did you also check vitd25oh and parathormone, this may help others to find the right balance of these two tests for response?in any case calcium is low so anything you find from vitd25oh will be safe, remember i am vitd25oh way higher than 1000ng/ml and no problems at all
as regards creatinine i think you should check creatinine clearance, it is probable that for your muscle mass your normal serum creatinine is normally higher than others with no issues.creatinine clearance will tell you the kidney function which i am sure it is optimal
Side effects from IFN are only listed on the packaging as an insurance against the maker of IFN. Some don't get any at all other than a fever the first injection. For me, I also experience very low WBC and neutrophils count.
To Lagona: Yes, your HBsAg is very low. Congrats. Instead of upping your Vit D3 dose, do you take zinc and selenium supplements as well? Hoped once your HBsAg becomes UNDETECTED, you developed surface antibodies simultaneously. Good luck!
they can not give you exact number when its higher than 70, not lower. If you supplement d3 or expect high result, you need to tell about it in the lab so they can dilute a sample and give you accurate result.
this is still a bit high, what is the minimum range in this lab?when pth gts lowest range of norm we know vit d is enough in your tissues/cells.vitd25oh is not precise because it just checks blood and if there is receptors resistance it is useless
Vitamine D Total : > 70 ng/ml
they need to dilute blood sample to get higher values but it is not important pth test will tell us when vit d is sufficient in tissues cells
you can supplement with about 3000-4000iu vit A retinoid type from cod liver oil per day to balance with vit d, this can reduce creatinine and make no vit d toxicity even if dose is too much
i already did this and my creatinine lowered from 1.3 to 0.68, at the same time i could reduce vit d dose and pth remained low norm range 17pg/ml (norm 10-80pg/ml)
if pth come less than normal range lower vit d dose
yes the best vit A is from cod liver oil which is the retinoic type and natural, if you find it ifos certified, also double check there is synthetic vit A added but it is the natural one
but i suggest to consume animal liver, all livers are full of vit A, it is best just to try it in the diet first because vitA can also block vit D if it is not in the right balance and this is too difficult.
if you see that creatinine goes out of range then you may try the one from cod liver oil and see if it balances vit d and make nromal creatinine
No side effects and such good response ? that's nice :) Maybe it d3 what helps.
I had some mild sites after first 4 shoots but now I feel normal.
How was your ALT during peginf thereapy ? What was the lowest/highest ?
Mine went up recently to 245 after 5 weeks.
You could show your doctor results of studies where they tested Interferon therapy for 96 weeks. I know of a this one, there might be others but I am not sure:
U should try zadaxin with ur last 7 injections. Y not give it a push. U r on the borderline. Ur virus seems stubborn to the extreme level but u should not give up coz it may relapse if u stop. U r on edge to win so try it.
obviously are the sides effects of interfron are the immune activation not intf itslef, its another virus, a different immune activation and hcv gets cleared by few weeks most of the time, hbv takes years on the few that get some weak immune activation
intf activates immune system for hcv way much more than it does for hbv that is why it is cleared fast, the high immune activation makes much more damage on some
this high immune activation, which makes much more damage and sides effects, clear hcv from a minimum of 50% to almost 80-90% of patients, nothing to do with the little immune activation on hbv 7% over 5years
Pork liver can do you more harm than good. Pork meat, especially liver is very unhealthy thing to consume, as pork are pretty much one of those rare animals that eat almost anything (all kinds of very dirty and unhealthy materials).
How old are you lagoona? Asking because of your good response on interferon...
Laguna...add black seed (grind it) and mix it with a big spoon of a quality organic tee. Eat that first thing every day, and then again the same late afternoon.
These two are known medicines since ancient times....prophetic medicines...I am pretty sure that will clear your hbsag in combo with 96 weeks of peginf.
You just buy it as seeds and then grind it like you grind salt (with a small grinding machine)
You can mix it with honey in a spoon and drink it in morning (don't take it too much as if taken a lot can be toxic)
It goes under various names:
too bad we didn t monitor closely enough to restart intf or other immune modulators to prevent relapse now better wait for cuban vaccine or replicor to be available or if you like retry intf if it had zero sides effects with something to boost immunity when hbsag very low like gcmaf and zadaxin
keep using vit d and wait for better drugs, i also had 1400iu/ml at the end of peg add on, 699iu/ml few months later and then up and down between 1300 and 1100iu/ml, i think more rounds of peg are needed but it doesn t worth the damage peg can do
better wait new drugs unless peg is zero sides effects, for me it was too heavy maybe 46yo is too old for pegintf without any damage
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