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INF + Tenofovir + Simavastatin
After treating with mono entecavir for 5 years, I decided to switch to tenofovir (Pavtino-B made in India) combo for two months.
And recently I have consulted with my doctor to add on interferon  Pegnano 180mcg/0.5mL made in Vietnam

Now I am on : INF Pegnano + Tenofovir + Vit D3 10.000IU + Simavastatin 40mg

Here is my status HBV

Date : 19/05/2014
HbsAg : 8462 IU/ml
Anti-hbe+ seroconversion year 4th entecavir
GGT : 38
ASAT : 38
ALAT : 29
Creatine : 12 mg/l
HBV DNA : Undectable since 3 months with Entecavir
Fibros scan : 4.3 kpa
Phophatase Alcaline : 156 UI/L
Alpha Foetoproteine : 2.28 ng/ml

After 6 Injections with interferon starting from 03/06/2014, here is the test result 15/07/2014

HbsAg : 7386 IU/ml
Anti-Hbe+
GGT : 75
ASAT : 79
ALAT : 87
Creatine : 12 mg/L
Vitamine D TOtal : 50 ng/ml

I am thinking to increase my dose on Vit D3 to 20.000 IU and Simavastatin to 80mg.

Can you give some advices?





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113 Answers
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Any bad side effects from peginterferon?
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Hi Elijah

I don't feel any side effects since the beginning.

everything is like normal as it is before getting inf.

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No side effects and such good response ? that's nice :) Maybe it d3 what helps.
I had some mild sites after first 4 shoots but now I feel normal.
How was your ALT during peginf thereapy ? What was the lowest/highest ?
Mine went up recently to 245 after 5 weeks.
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You could show your doctor results of studies where they tested Interferon therapy for 96 weeks. I know of a this one, there might be others but I am not sure:
http://www.ncbi.nlm.nih.gov/pubmed/22859496
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How old are you lagona?
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U should try zadaxin with ur last 7 injections. Y not give it a push. U r on the borderline. Ur virus seems stubborn to the extreme level but u should not give up coz it may relapse if u stop. U r on edge to win so try it.
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I'm thinking I should've tried peginterferon instead of tenofovir. But the horror stories from peginterferon scares me.
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Only peg can give u a chance to clear the virus not tdf
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6359077 tn?1441489904
Wow!! its great that things are working out for you.  So happy for you :)  Wish you the best!!
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Yes I know but I'm afraid of the side effects from Tenofovir
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What horror stories ? Most of the people have side effects but they are not very bad. I'm after six shoots and for now it's ok. Only first one was quite hard, high temp, shingles.
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all here are reporting minor sides effects, i think that the use we do of vitamin d is preventing heavy sides and boosting response, as more members will be on it this will be easy to confirm

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This week after 15th shot m feeling continuos nausea though :(
At 6-8th shots I had vomiting and abdominal discomfort
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Do a quick Google search of people that have tried peginterferon. Many people have side effects that didn't go away after treatment.
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that s hcv and it is different to hbv.


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How are the sides different from people with HCV?
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obviously are the sides effects of interfron are the immune activation not intf itslef, its another virus, a different immune activation and hcv gets cleared by few weeks most of the time, hbv takes years on the few that get some weak immune activation

intf activates immune system for hcv way much more than it does for hbv that is why it is cleared fast, the high immune activation makes much more damage on some
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this high immune activation, which makes much more damage and sides effects, clear hcv from a minimum of 50% to almost 80-90% of patients, nothing to do with the little immune activation on hbv 7% over 5years
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I really reading your comments very much.

stef : I try to add on animal liver (mostly pork liver) in my diet.

but I might not get it every meal.

thank u all
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Pork liver can do you more harm than good. Pork meat, especially liver is very unhealthy thing to consume, as pork are pretty much one of those rare animals that eat almost anything (all kinds of very dirty and unhealthy materials).

How old are you lagoona? Asking because of your good response on interferon...
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organic grass fed meat animals is the best choice although i dont know if countries outside europe has this easily available
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Agreed. Recently I trying to eat more fish...as it tends to be more healthy
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Yes Adusiki I am 35 years old.

anyway beside pork liver ot seems hard to find any other kind of liver to eat.

I might find the Vit A capsule instead.

thanks
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I think I will go for interferon myself, before I get to old for it.
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It was one of the reasons I've decided to try, I'm 36.
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Can you please post your baseline results, and then result on treatment if you have any yet, pls
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responded in my therapy thread
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my PTH  test come out

PTH : 21,98 pg/mL (N : 16 - 65)

It is increasing while Vit D level is not tested yet.


Any idea are welcome.
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Laguna...add black seed (grind it) and mix it with a big spoon of a quality organic tee. Eat that first thing every day, and then again the same late afternoon.
These two are known medicines since ancient times....prophetic medicines...I am pretty sure that will clear your hbsag in combo with 96 weeks of peginf.

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p.s. find a quality black seed as well
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It s good keep it aroun 20 (16-20)
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So only one person on here cleared with the help of black seed?
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Hi Stef

Please check your private messages
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Black seed : It is in the form of capsul, liquid or what?

I never heard people in my country (Cambodia) talk about it before.


Actually I take turmeric power with black pepper (a coffee spoon of turmeric per day) knowing it from a friend to reduce stressed.

And I drink it with mineral water.


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You just buy it as seeds and then grind it like you grind salt (with a small grinding machine)
You can mix it with honey in a spoon and drink it in morning (don't take it too much as if taken a lot can be toxic)
It goes under various names:
Black seed
Nigella sativa
Black cumin
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It's toxic when it's 25 grams or more but who would even think about taking that much?
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Still checking it, there s no proof at all it can make any difference to clearance but since it is not harmful we r trying it

We have 2 reported that cleared in combo etv or tdf, but can be just coincidence and they were to clear on their own or by the nuc
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Hi Stef and All,

It is likely interferon has a little effect on me during the period of the final course 72 injections INF ( now i am on 71st)
Here the result after 71 injections 09-10-2015 :

Phophatase Alcaline : 175  (N<270)
GGT : 59
ASAT : 46
ALAT :43

HbsAg quantitative (Cobas e601 ) : 22,8 IU/mL down from 27,71 IU/mL (26-Aug-2015)

RIght now there is only one injection left and the doctor recommended me  to stop the treatment Interferon + Tenofovir  and suggest the examination control every 3 months to see if it will be relapsed.

He think below 100 IU/mL will be cleared by post-effect-interferon after the stop.

Anyone can recommend ?

Thanks,
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He think below 100 IU/mL will be cleared by post-effect-interferon after the stop.

i do agree with him but best keep tenofovir after you finish peg, new drugs like cuban vaccine or replicor when available will clear your hbsag in a bit

stopping tdf too can have 2 results:
hbvdna will rise immune system will see it and activate and clear hbsag

hbvdna will rise and hbsag will relapse and you get back to baseline and peg use is wasted

we also have a member who used tdf for many years and used tdf+gcmaf sublingual+ vit d3 with a baseline hbsag like yours around 20iu/ml, he cleared hbsag by 6 months
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thank stef

so I should continue tenofovir + Vit d3 and finish INF according to ya recommendation and I am thinking that way too.

I will discuss it with doctor whether he agree because I don't want to waste what I did with interferon.
thanks
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After 7 months of stopping interferon  my HbsAg is relapse to 1610 IU/ml.

Does it means the post effect of INF is not strong enough to counter the 22IU/ml which is left before finishing INF.

Do you think it will continue to rise till the stat before INF treatment?
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Did u keep taking tenofovir after stopping Pegasys?
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Yeah I keep taking tenifovir daily
But somehow it goes up so rapidly.
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this is a big dissapointment  coz u got so close to remove the infection but bad luck. Like everytime wait with the time.
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Yeah I am really unlucky to recover from this disease. So time will tell with the future treatment.
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too bad we didn t monitor closely enough to restart intf or other immune modulators to prevent relapse now better wait for cuban vaccine or replicor to be available or if you like retry intf if it had zero sides effects with something to boost immunity when hbsag very low like gcmaf and zadaxin
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Thank for response,
Personally I prefere to wait for the next version of treatment.

Beside INF, gcmaf and zadaxin are hard to find in my country even most of doctor are not aware of it.
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Hi stef2011,
Do you think it will relapse till base line as before treatment of INF?

With much surface antigent in liver, does it will impact the liver or  make more damage to it?
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hbsag level makes no difference, just slightly more hcc risk compare to hbsag less than 1000iu/ml but i would not worry too much now about it, what about hbvdna and alt?
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My result :
Phophatase Alcaline : 82 UI/L
Alpha Foetoproteine : 1.86 ng/ml

ASAT  : 37
ALAT : 32
GGT : 37

HBsAg Quantitative (Cobas e601) : 1610 IU/ml

HBV DNA : Undectable
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keep using vit d and wait for better drugs, i also had 1400iu/ml at the end of peg add on, 699iu/ml few months later and then up and down between 1300 and 1100iu/ml, i think more rounds of peg are needed but it doesn t worth the damage peg can do
better wait new drugs unless peg is zero sides effects, for me it was too heavy  maybe 46yo is too old for pegintf without any damage
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Thank Stef for comment.
I will restart my dose of Vit D for 10.000 IU/ml
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