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INF + Tenofovir + Simavastatin

After treating with mono entecavir for 5 years, I decided to switch to tenofovir (Pavtino-B made in India) combo for two months.
And recently I have consulted with my doctor to add on interferon  Pegnano 180mcg/0.5mL made in Vietnam

Now I am on : INF Pegnano + Tenofovir + Vit D3 10.000IU + Simavastatin 40mg

Here is my status HBV

Date : 19/05/2014
HbsAg : 8462 IU/ml
Anti-hbe+ seroconversion year 4th entecavir
GGT : 38
ASAT : 38
ALAT : 29
Creatine : 12 mg/l
HBV DNA : Undectable since 3 months with Entecavir
Fibros scan : 4.3 kpa
Phophatase Alcaline : 156 UI/L
Alpha Foetoproteine : 2.28 ng/ml

After 6 Injections with interferon starting from 03/06/2014, here is the test result 15/07/2014

HbsAg : 7386 IU/ml
Anti-Hbe+
GGT : 75
ASAT : 79
ALAT : 87
Creatine : 12 mg/L
Vitamine D TOtal : 50 ng/ml

I am thinking to increase my dose on Vit D3 to 20.000 IU and Simavastatin to 80mg.

Can you give some advices?





113 Responses
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Avatar universal
Thank Stef for comment.
I will restart my dose of Vit D for 10.000 IU/ml
Helpful - 0
Avatar universal
keep using vit d and wait for better drugs, i also had 1400iu/ml at the end of peg add on, 699iu/ml few months later and then up and down between 1300 and 1100iu/ml, i think more rounds of peg are needed but it doesn t worth the damage peg can do
better wait new drugs unless peg is zero sides effects, for me it was too heavy  maybe 46yo is too old for pegintf without any damage
Helpful - 0
Avatar universal
My result :
Phophatase Alcaline : 82 UI/L
Alpha Foetoproteine : 1.86 ng/ml

ASAT  : 37
ALAT : 32
GGT : 37

HBsAg Quantitative (Cobas e601) : 1610 IU/ml

HBV DNA : Undectable
Helpful - 0
Avatar universal
hbsag level makes no difference, just slightly more hcc risk compare to hbsag less than 1000iu/ml but i would not worry too much now about it, what about hbvdna and alt?
Helpful - 0
Avatar universal
too bad we didn t monitor closely enough to restart intf or other immune modulators to prevent relapse now better wait for cuban vaccine or replicor to be available or if you like retry intf if it had zero sides effects with something to boost immunity when hbsag very low like gcmaf and zadaxin
Helpful - 0
2 Comments
Thank for response,
Personally I prefere to wait for the next version of treatment.

Beside INF, gcmaf and zadaxin are hard to find in my country even most of doctor are not aware of it.
Hi stef2011,
Do you think it will relapse till base line as before treatment of INF?

With much surface antigent in liver, does it will impact the liver or  make more damage to it?
Avatar universal
Yeah I am really unlucky to recover from this disease. So time will tell with the future treatment.
Helpful - 0
Avatar universal
this is a big dissapointment  coz u got so close to remove the infection but bad luck. Like everytime wait with the time.
Helpful - 0
Avatar universal
Yeah I keep taking tenifovir daily
But somehow it goes up so rapidly.
Helpful - 0
Avatar universal
Did u keep taking tenofovir after stopping Pegasys?
Helpful - 0
Avatar universal
After 7 months of stopping interferon  my HbsAg is relapse to 1610 IU/ml.

Does it means the post effect of INF is not strong enough to counter the 22IU/ml which is left before finishing INF.

Do you think it will continue to rise till the stat before INF treatment?
Helpful - 0
Avatar universal
thank stef

so I should continue tenofovir + Vit d3 and finish INF according to ya recommendation and I am thinking that way too.

I will discuss it with doctor whether he agree because I don't want to waste what I did with interferon.
thanks
Helpful - 0
Avatar universal
He think below 100 IU/mL will be cleared by post-effect-interferon after the stop.

i do agree with him but best keep tenofovir after you finish peg, new drugs like cuban vaccine or replicor when available will clear your hbsag in a bit

stopping tdf too can have 2 results:
hbvdna will rise immune system will see it and activate and clear hbsag

hbvdna will rise and hbsag will relapse and you get back to baseline and peg use is wasted

we also have a member who used tdf for many years and used tdf+gcmaf sublingual+ vit d3 with a baseline hbsag like yours around 20iu/ml, he cleared hbsag by 6 months
Helpful - 0
Avatar universal
Hi Stef and All,

It is likely interferon has a little effect on me during the period of the final course 72 injections INF ( now i am on 71st)
Here the result after 71 injections 09-10-2015 :

Phophatase Alcaline : 175  (N<270)
GGT : 59
ASAT : 46
ALAT :43

HbsAg quantitative (Cobas e601 ) : 22,8 IU/mL down from 27,71 IU/mL (26-Aug-2015)

RIght now there is only one injection left and the doctor recommended me  to stop the treatment Interferon + Tenofovir  and suggest the examination control every 3 months to see if it will be relapsed.

He think below 100 IU/mL will be cleared by post-effect-interferon after the stop.

Anyone can recommend ?

Thanks,
Helpful - 0
Avatar universal
Still checking it, there s no proof at all it can make any difference to clearance but since it is not harmful we r trying it

We have 2 reported that cleared in combo etv or tdf, but can be just coincidence and they were to clear on their own or by the nuc
Helpful - 0
Avatar universal
It's toxic when it's 25 grams or more but who would even think about taking that much?
Helpful - 0
Avatar universal
You just buy it as seeds and then grind it like you grind salt (with a small grinding machine)
You can mix it with honey in a spoon and drink it in morning (don't take it too much as if taken a lot can be toxic)
It goes under various names:
Black seed
Nigella sativa
Black cumin
Helpful - 0
Avatar universal

Black seed : It is in the form of capsul, liquid or what?

I never heard people in my country (Cambodia) talk about it before.


Actually I take turmeric power with black pepper (a coffee spoon of turmeric per day) knowing it from a friend to reduce stressed.

And I drink it with mineral water.


Helpful - 0
Avatar universal
Hi Stef

Please check your private messages
Helpful - 0
Avatar universal
So only one person on here cleared with the help of black seed?
Helpful - 0
Avatar universal
It s good keep it aroun 20 (16-20)
Helpful - 0
Avatar universal
p.s. find a quality black seed as well
Helpful - 0
Avatar universal
Laguna...add black seed (grind it) and mix it with a big spoon of a quality organic tee. Eat that first thing every day, and then again the same late afternoon.
These two are known medicines since ancient times....prophetic medicines...I am pretty sure that will clear your hbsag in combo with 96 weeks of peginf.

Helpful - 0
Avatar universal
my PTH  test come out

PTH : 21,98 pg/mL (N : 16 - 65)

It is increasing while Vit D level is not tested yet.


Any idea are welcome.
Helpful - 0
Avatar universal
responded in my therapy thread
Helpful - 0
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