Title INTERLEUKIN-28B GENE POLYMORHISM MAY AFFECT THE NATURAL COURSE OF HEPATITIS B and DELTA VIRUS INFECTIONS
Speaker: A. Mithat Bozdayi
Author: A.M. Bozdayi1,2*, T. Ozturk1, S. Altuntas1, S.C. Karatayli1, E. Karatayli1, C. Inci1, K. Cinar2, R. Albayrak3, M. Ozkan3, Y. Kendal4, R. Idilman2, C. Yurdaydin1,2
Affiliation: 1Institute of Hepatology, 2Department of Gastroenterology School of Medicine, 3Biometry Genetics Department, Ankara University, Ankara, 4Department of Gastroenterology, Dicle University Faculty of Medicine, Diyarbakir, Turkey. *mithat.***@****
Background and aims: It has been suggested that interleukin-28B (IL-28B) polymorphisms are associated with spontaneous clearance of hepatitis C virus (HCV) and be a strong determinant of sustained virologic response in genotypes 1 to 3 HCV. Effect of IL28B polymorphism in treatment response to interferons and outcome in hepatitis B virus infection is much less investigated. The aim of the current study was to investigate a potential association between several single nucleotide polymorphisms (SNPs) of the IL-28B gene (rs12979860, rs1188122, rs8099917, rs8105790, rs12980275) and the natural course of HBV and hepatitis delta virus (HDV) infections.
Material-methods: The study included the following groups: group 1: 211 patients with HBV infection (49 inactive HBV carriers; 162 chronic HBV patients); group 2: 124 anti HBsAg positive persons and group 3: 103 patients with chronic HDV infection. DNA sequencing results were interpreted statistically with the chi-square test and the independent variables were determined by calculating the corresponding odds ratio (OR) and its 95% confidence interval (95% CI) by means of simple logistic regression.
Results: A significant difference (p< 0.01) between group 2 (anti-HBsAg positive) and group 3 (patients with HDV infection) for
(i) TT genotype of rs12979860
(ii) TG and GG genotypes of rs8099917 and
(iii) CC genotype of rs8105790. Significant differences (p< 0.01) were also detected between group 1 (patients with hepatitis B virus infection) and group 2 (anti-HBsAg positive) for
(i) GG genotype of rs8099917,
(ii) TT and TC genotypes of rs8105790. Interestingly, highly significant differences were observed within group 1 patients (patients with hepatitis B virus infection) between inactive HBV carriers and patients with chronic hepatitis B for
(i) TG and GG genotypes of rs8099917 (p< 0.0001) and
(ii) TT and TC genotypes of rs8105790 (p< 0.0001)
Conclusion: These results suggest that IL-28B polymorphisms may affect the natural history of HBV infection:
(i) it may be associated with the development of natural immunity;
(ii) it is a strong determinant of the inactive HBsAg carrier state;
(iii) it may affect progression to chronic B hepatitis following HBV infection; and
(iv) may also be involved in progression of HDV infection to chronicity.
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