IgM anti HBc

[Jonani]

Hello Team
Am Biomedical Lab technologist working with Health center In kasese, Uganda, a region of the country where HEP B is on the raise.

My query concerns there management. After going through a panel test for HEPBsAg +ve, and IgM anti HBc -ve, which probably indicate a likely hood of a chronic HBV infection with review of clinical history, how would you proceed to help treat that kind of patient. And if they are not liable to treatment, what aids that conclusion?

In some recommendations, i have read monitor within arange of 4-6 weeks. In that regard are you waiting for any relapse of clinical signs or?

My overall concern is patients ruled to in chronic state of HBV infection are not being given treatment, neither are they being followed up due to lack of knowledge. Can you please advise technically?

[melcul]

Stef, i read the possible side effects on entecavir and tdf, the worst ones were acut renal failure and lactic acidose ,they mention they are rare , but still, you take them from some time now, can it be prevented ?

[stef2011]

browse all posts and you ll find all the answers, hbv is very very complicated even for most liver specialists and most are ignorant about it

the only cure is sequential treatment of tenofovir or entecavir for 5-10years and then peginterferon add on.hbsag quantity in iu/ml (abbott architect or elecsys roches) determines when to add and clearance of infection.add on is best when hbsag is less than 1000iu/ml because clearance rates are 91%