Importance of vitamin d levels to help control HBV replication

[studyforhope]

Hepatology. 2013 May 22. doi: 10.1002/hep.26488. [Epub ahead of print]
Low vitamin D serum concentration is associated with high levels of hepatitis B virus (HBV) replication in chronically infected patients.
Farnik H, Bojunga J, Berger A, Allwinn R, Waidmann O, Kronenberger B, Keppler OT, Zeuzem S, Sarrazin C, Lange CM.
Source
Medizinische Klinik 1, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, Haus 11, 60590 Frankfurt, Germany.
Abstract
Vitamin D is an important immune modulator which plays an emerging role in inflammatory and metabolic liver diseases, including infection with hepatitis C virus (HCV). In contrast, the relationship between vitamin D metabolism and chronic hepatitis B is less well characterized. Therefore, we quantified 25-hydroxyvitamin D [25(OH)D3 ] serum levels in a cohort of 203 treatment-naïve patients with chronic hepatitis B virus (HBV) infection and tested for their association with clinical parameters of chronic hepatitis B. 69 (34%), 95 (47%), and 39 (19%) out of 203 patients had severe vitamin D deficiency [25(OH)D3 <10ng/mL], vitamin D insufficiency [25(OH)D3 ≥10ng/mL and <20ng/mL], or adequate vitamin D serum levels [25(OH)D3 ≥20ng/mL], respectively. In both uni- and multivariate analyses, HBV DNA viral load (log10 IU/mL) was a strong predictor of low 25(OH)D3 serum levels (p=0.0007 and p=0.000048, respectively), and vice versa. Mean 25(OH)D3 serum concentrations in patients with HBV DNA <2000 IU/mL vs. ≥2000 IU/mL were 17 vs. 11 ng/mL, respectively (p<0.00001). In addition, hepatitis B early antigen (HBeAg) positive patients had lower 25(OH)D3 serum levels than HBeAg negative patients (p=0.0013). Finally, 25(OH)D3 and HBV DNA serum levels showed inverse seasonal fluctuations. Conclusions: Low 25(OH)D3 serum levels are associated with high levels of HBV replication in patients with chronic hepatitis B. This represents a major difference to chronic hepatitis C, were numerous previous studies have shown a lacking correlation between HCV viral load vitamin D serum levels. Inverse seasonal fluctuations of 25(OH)D3 and HBV DNA serum levels are suggestive for a functional relationship between both variables. (HEPATOLOGY 2013.).
Copyright © 2013 American Association for the Study of Liver Diseases.

[veteranB]

I still think guys we need to try to use 50.000 units daily what cancer patients do to see the effect. Just up the vitamin k2 intake.

[stef2011]

20.000iu can still be ok if vitd25oh less than 100ng/ml but not 50.000iu daily

be aware that tissue calcification can happen even with normal calcium if vit k2 deficent, some pains in the back close to kidneys area are gone as soon as started k2, so it is possible i was k2 deficent

[BeachTiePurist]

if vitamindwiki is recommending 10.000 IU for healthy people, then why are you sticking with 10.000 IU?

I felt better on 20.000 IU.  It's twice as much, and no sides so far.  I take heptech, but don't supplement K2M7 or anything else.

[stef2011]

everybody takes the doses to make levels high end of normal 90-100ng/ml, not 50.000iu when levels are already at 70ng/ml plus everybody taking it has usually levels around 10-15ng/ml

at baseline 10ng/ml a dose 50.000iu or higher weekly is a must but not when baseline vitd25oh is high

[veteranB]

So how do cancer patients do it? As you said some take very high doses.

[stef2011]

i dont think it is safe to take so much d3 if levels are high already like 70-80ng/ml and without vit k2, such experiments must be done under the supervision of expert doctors and checking closely vitd25oh and calcium in tissues by tomography

i also dont think we can clear hbv by simply making vitd25oh over 100ng/ml even acute hbv takes 6-12 months to clear hbsag so it is going to be a slow and long process and keeping so high vit d for long times might be dangerous for tissue calcification

[stef2011]

any vit d3 is ok if pills are in liquid olis for absorption, the dose must be adjusted according to your response and vit k2 is absolutely needed to fix calcium in the bones and not keep it in tissues/blood

[charan123]

Hi Stef,

Please suggest me the best Vitamin D suppliment . what about taking gs9620  ?

Thanks

[veteranB]

What do you think of beta glucans?

[veteranB]

Then maybe taking gs9620 with high doses can help us clear this?

Should we try taking 50000 units daily and see what happens?

[stef2011]

www.vitamindwiki.com/dl1166

Vitamin D and the Immune System

[stef2011]

the link is pretty simple by this study:
http://www.natureandhealth.com.au/news/vitamin-d-virus-killer

vitamin d influences trl7 which is the receptor to detect ssrna of hbv virus in infected cells, so increasing vit d we increase trl7 receptor activation and clearance of more hbv

i think this is the major key of vit d being against hbv

[veteranB]

Look at hiv data. As soon as they start taking high doses of vitamin d and c their viral load falls. It is known. Good doctors will tell you off the record. That oh well high doses of vitamin d are good for you. Search youtube also there is a good info.

[Rome70]

"Low 25(OH)D3 serum levels n relation with HBV is a cause or a result ? "
You put up interesting topic. I think that  vit d3 deficiency is a result and not a cause, because there was a number of studies about how people become chronic and it is clear that lacking of vit d3 would have been easily spotted but it was not.

I also did not see any study that proves that Vit D3 supplementation has any direct effect on HBV, but d3 defficiency is certainly not good for immune system in general so probably supplementing Vit D3 improves general health and therefore has indirect effect on hbv too.

[stef2011]

nagalase is produced naturally

used wrong words, it is all produced naturally both from viruses, bacteria or cancer cells.....what i meant is nagalase is not pathological when produced at low levels by gut healthy bacteria or in pregnancy

[stef2011]

nagalase can be decreased by probiotic gcmaf or injectable gcmaf only or removing the source of it
nagalase is produced naturally only by pregnant women to avoid fetus rejection and by our healthy bacteria in the gut (but at very low levels less than 0.6nmol/mg) to escape our immune system detection

clearing nagalase from our blood means improved immune function but not hbv clearance and also nagalase levels in blood are much less than levels in the liver for sure

[newtr]

how would be it ? if we all members do a survey within ourselves about vit d levels and ours hbvdna or hbsag ,before and after vit d suppliments. that would be nice to give a hint about "vit d effect",may be a seperate post.

[newtr]

what is nagalase levels ,how to measure them  and its importance in hvb? have research seen anybody cured from vit d suupliments?

[veteranB]

besides gcmaf, what we can take to reduce nagalase levels?

[stef2011]

i think low vit d is due to immune system mulfunction since all chronic diseases from all virus infections to cancers have low vit d and all improve increasing vit d

all viruses use ways to suppress immune function otherwise they cannot stay in our bodies (same thing cancer cells) and all target vitamin d...maybe the whole thing is about nagalase, vit d, vdr, gcmaf and immune system activation because all chronic diseases have low vit d, abnormal nagalase and deficent immune activation

[4est]

Low 25(OH)D3 serum levels n relation with HBV is a cause or a result ?

Active HBV is becuse we have low vit D or we have low vit D because we have HBV?
Do you know any  study that rellate the suplimantary vit D with HBV ?

[veteranB]

I see then I need to take more vitamin K. My calcium is maxed out.

[stef2011]

http://articles.mercola.com/sites/articles/archive/2012/12/16/vitamin-k2.aspx

IMPORTANT: If You Take Vitamin D, You Need K2

This is a really crucial point: If you opt for oral vitamin D, you need to also consume in your food or take supplemental vitamin K2.

"There are so many people on the vitamin-D-mega-dose bandwagon, taking more and more of vitamin D. And it could absolutely be causing harm if you are lacking the K2 to complete the job to get the calcium where it's supposed to be," Rheaume-Bleue warns.

"We don't see symptoms of vitamin D toxicity very often. But when we do, those symptoms are inappropriate calcification. That's the symptom of vitamin D toxicity. And it is actually a lack of vitamin K2 that can cause that..."

While the ideal or optimal ratios between vitamin D and vitamin K2 have yet to be elucidated, Rheume-Bleue suggests about 150-200 micrograms of K2 will meet the need for the "average" healthy person.

The latest vitamin D dosing recommendations, which call for about 8,000 IU's of vitamin D3 per day if you're an adult, means you'd need in the neighborhood of 800 to 1,000 micrograms (0.8 to 1 milligram/mg) of vitamin K2, but the jury is still out.

"My earlier recommendation was not taking into account people who were doing high dose of vitamin D supplementation," Rheaume-Bleue says. "That's where it gets a little bit more technical. It seems that for the average person, around 200 to 280 micrograms will activate your K2 proteins and do a lot of good for your bones and your heart. If you're taking high levels of vitamin D... then I would recommend taking more K2."

The good news is that vitamin K2 has no toxicity. No toxic effects have ever been demonstrated in the medical literature.

"The reason why K2 doesn't have potential toxic effect is that all vitamin K2 does is activate K2 proteins. It will activate all the K2 proteins it finds. And if they're all activated and you take extra K2, it simply won't do that. That's why we don't see a potential for toxicity the way we do with vitamin A or D," she says.

[stef2011]

intersting article about vit d and vitamin k2, only this type of k2: MK-7 (Vitamin K2 as Menaquinone-7 from Natto Extract).looks like some research is proving vit d toxicity is due to k2 deficency but anyway it makes sense to combo d3 and k2 together especially for the prevention effect of both d3 and k2 (mk7 from natto) on liver cancer

http://articles.mercola.com/sites/articles/archive/2011/03/26/the-delicate-dance-between-vitamins-d-and-k.aspx