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Inactive HBV carrier
Hi Friends,
                  I'm HbsAg positive since 2 yrs. My HbeAg is negative and Ati HBe is positive and HBV_DNA_PCR is negative since 2 yrs. My ALT is also normal from 2yrs. No symptoms also. Doctor has classified me as an Inactive HBV carrier.. I haven't had any medication since 2 yrs, But today (1/12/2012) doctor has given me Lamivir HBV 100mg tablets once in a day in the morning.
                     Now my question is What is the status of my HepB and Shall I start this medication to bring HbsAg negative.
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@jalakmohamed,i am in the same shoes as yours,i was kicked out from UAE after testing hbsag+.that was the first time i heard of hepatitis.we don't do such test in my country and i have never failed hiv,xray,tb,syhillis,and others coz i do those regularly and thought all was well with me until i travelled to uae and got a job and did medical and was sent home. Its so sad,no symptons since i was born and in my 30s now.i am jobless now coz of this ,i find it hard to even go for full lab test coz their is no money.all i am takin now is antiviral herbs .i am just taking them and since i was tested in uae ,i haven't done any test since i got to my country coz no much money,all money is gone on travelling.uptil now,i never fall sick,i still believe this thing will go on its own.i never had fun without protection,no tatoo,no blood tranfusion.since doubtful of what could have caused this.possibly from childhood and didn't notice.i am from nigeria.
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Hi Bro,
               Can You please explain why my hbsag is increasing. I'm confused

Test Name Cuto OFF Base Line
1st Week 2nd week 3rd week 4th week 5th week 6th week 7th week 8th week
HBsAg : 10 mIU/mL 0.1 0.33
HBeAg : <1.00 S/Co Non Reactive 0.335
Anti HBe: 20 ng/mL 12.21
Cholesterol:
Total Cholesterol <200 mg/dL 124
HDL 40-60 mg/dL 27
LDL 85-150 mg/dL 75
VLDL 7-35 mg/dL 22
Triglycerides Normal < 150 mg/dL 112
TC/HDL Ratio 3.9 - 5.0 4.6
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Hi Bro,
               Can You please explain why my hbsag is increasing. I'm confused
1st Week 2nd 3rd 4th 5th 6th 7th 8th week
HBsAg :51.15,39.71,37.53,33.43,32.85,39.6,35.2, 28.24,39.84
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Hi Bro,
can i add gcmaf along with the combo of int+niz500+sim40mg. if yes can you give me the gcmaf brand name in india and where i can get it
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Hi! Any update on your results?
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Hi Bro,
Sorry for late update.. As You said I had been in interf, simvastin, Vitd3 and alina for a year.. My interf got completed on 9th Jan 2014... As on Jan my hbsag was 14.75 iu/ml.. After that I was maintaining Simvastin and Vitd3.. Now since 3 weeks my hbsag is 7.71iu/ml.. there is no variation in values.. Please suggest me how to proceed from now...
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Hi Bro,
Sorry for late update.. As You said I had been in interf, simvastin, Vitd3 and alina for a year.. My interf got completed on 9th Jan 2014... As on Jan my hbsag was 14.75 iu/ml.. After that I was maintaining Simvastin and Vitd3.. Now since 3 weeks my hbsag is 7.71iu/ml.. there is no variation in values.. Please suggest me how to proceed from now...
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you should not have stopped peginterferon once there is response at 12 or 24 weeks peginterferon must be continued as long as hbsag und and hbsab are formed.
48weeks treatment is an obsolete from the era of hbsag quantification not available and so 48 weeks were used whatever....today personalized treatment requires stop at 24 weeks if there is no hbsag decline and prolonged treatment until hbsag loss

if sides effect are tollerable it is best to restart peginterferon as soon as possible until hbsag und and hbsab>100miu/ml (hbv vaccine can be used to boost hbsab once hbsag is und)

you can also stay off treatment because hbsag<10iu/ml has totally inactive infection and will slowly clear by 3 or 5 years (dont remember which one) in almost 100% cases, but if you had only 48weeks of peg it is best to prolong it because the maximum effect of pegintf on immuen system is right after 48weeks
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of course keep monitoring hbsag because if you see any rise it is best to go back to peg as soon as possible

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sorry it is not 100% hbsag loess when hbsag<10iu/ml by 3-5years but very very high probability, some studies report 52% probability at 3 years
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Hi Bro,
                I was on peg interf for 54 weeks continuous. and now my hbsag is 7iu/ml and the cut off value is .05iu/ml.. You asked me to continue for 48 weeks of interferon therapy and i took for 54 weeks.. I stopped peg in jan2014.. Now I am on vitd5 60000 iu/ml weekly with nizonide 500mg twice a day. and simvastin 20mg daily.. Since 3 weeks Imy hbsag levels are unchanged.. please let me know because i am totally confused
      
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two choices:

keep monitoring for another 3 months because peginterferon keeps working even after you have finished when hbsag is less than 1000iu/ml at end of therapy.if you see it keeps going down do not start pegintf but if you see a rise of hbsag start peg immediately

start pegintf again for another 42 weeks (total 96weeks), the best response of pegintf is on 96 weeks when patients respond (respond means hbsag decline by 12 or 24 weeks).

what are your current vitd25oh levels?
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hi,,mmy hbsag 250 iu/ml.lft is normal. hbv dna is less then decattable.mr dr give liv52 hb.only and says it will be clear automatic ,,i am very  confused ,,what can i  do?? help me plz urgent
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hi i have been infected with Hepatitis-B 6 years back some  2 years am using Lamivir HBV (100 mg)  and am stopped now my liver is enlarged having 18.8 cm and sign of hepatomegaly now again started a bow tbs is it possible to  recover from this
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lamivudine is not an hbv drug anymore and makes extremely dangerous mutants and resistance

now the only drug for hbv that you can use is tenofovir (antiviral) or peginterferon (immune modulator)
the antivirals are never meant to stop, they only block liver damage and dont cure or clear hbv, so you have to take tenofovir for life unless hbsag becomes negative
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please can you help me with my case i am an inactive carrier of hep. b so where can i start from..
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I am eAg negative / SAg positive carrier, completely normal ALT / AST levels, no liver tumor markers, but a liver biopsy showed 0-1 minor scarring in line with a hepatitis infection.  Also, my PCR load fluctuates between 3-6K, so I'm recommended to start anti-virals to suppress the load down to undetectable.  So, I'm consider Tenofovir, what are your thoughts?
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Hi Steff,
                     Now my Hbsag levels are 1.45 IU/ml.. I still take vitd3 60000 IU/ml weekly. my alt and ast are normal, Hbeag is negative, hbv dna is negative. I have complted another 54 weeks of peginterferon.
                      Totally i was on peginterferon for 2 yrs. but still my hbsag is not negative.. pls tell me what to do now??? Very confused.
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Hi Bro,
             Now my Hbsag levels are 1.45 IU/ml.. I still take vitd3 60000 IU/ml weekly. my alt and ast are normal, Hbeag is negative, hbv dna is negative. I have complted another 54 weeks of peginterferon.
                      Totally i was on peginterferon for 2 yrs. but still my hbsag is not negative.. pls tell me what to do now??? Very confused.
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is hbsab still undetectable?

you may try zadaxin or zadaxin plus hbv vaccine to see if hbsab increase and it helps clear the little hbsag left

or just wait and see if it gets cleared slowly.which date you finished peg?such low level should clear on its own slowly in the next 5years

of course keep the vit d3 and if possible change to 10.000iu daily instead of weekly doses
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You have achieved a very good response for your prolonged Interferon treatment. There is not guarantee that Interferon treatment will clear HBsAg. I am at a loss at which you can do next, but I am sure you will remain in this non-active disease state for a long time as your HBsAg level is so low. Maybe you will s-seroconvert in the coming months.
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moving in to sperimental pdl1 drugs will sure clear remining hbsag and fear of liver damage should be null because virus/cccdna left is extremely low....just monitor for 2 years or try zadaxin immediately for now and let us know

zadaxin is better than peg to make hbsab when hbsag is so low
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Hi Bro,
             Thanks for the update. I've finished the peg interferon on 2nd April 2015. Is zadaxin in the injection form or pills form. Please name some of the HBV vaccines so that i can try if i can get in india.
               I've a doubt, if i use hbv vaccine, wont it raise my hbsag levels because as i heard from hbv vaccine, it is the dummy hbv virus created from yeast of something i don't remember it.
             i will raise my vit d3 supplements to 10000 iu daily. again thanks for the update
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Hi Bro,
             Thanks for the update just pray for me.

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Yes my hbsab is undetectable
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Nice to see how you are fighting, hope you'll have HBsAg- soon ! Please keep us updating !
Stef, how about adding selenium to his supplementation ? There was a study that it improved vaccacine response in diabetic t1 people as I remember, maybe its worth to try anyway since its cheap and safe ?
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Yes you are right to get max from vit d he should add magnesium chelate 400mg daily, vit a from cod liver oil 3500iu daily, zinc, selenium 400mcg daily (dont remember the name of best selenium, maybe some name similar to seleniomethionine) but this is not sure to make hbsag neg

the most potent choice now would be zadaxin and maybe hbv vaccine
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Hi Steff,
                 About HBV Vaccine there are 2 types. one is hepatitis B Immunoglobulin (Passive vaccine) and the other is Hepatitis B surface antigen protein (Active vaccine), which one should i use.
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I've a doubt, if i use hbv vaccine, wont it raise my hbsag levels because as i heard from hbv vaccine, it is the dummy hbv virus created from yeast of something i don't remember it.
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I've a doubt, if i use hbv vaccine, wont it raise my hbsag levels because as i heard from hbv vaccine, it is the dummy hbv virus created from yeast of something i don't remember it.
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No the vaccine will not rise hbsag, immune cells will pick it up

i think that a combo of zadaxin first and then immune globulin and hbv vaccine may help

The best vaccine is the one from cuba, dont remember the brand name, but it is not sold yet

Since u finished peg april 2nd it will keep working for 6 to 12 months.now that you stopped it there will be a rise in WBC and other immune cells, so give it 6months to see, then if no decline or even rise go for zadaxin
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Zadaxin is by injections
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Another thing you may try immediately is gcmaf -goleic from europe or gcmaf from saisei japan together with vit d3.i actually had good response during pegintf only when adding to it goleic-gcmaf and high dose vit d3

when taking vit d3 only i could only keep steady hbsag level but no decline, no vit d3 no gcmaf and only pegintf complete relapse and hbsag increase to baseline levles,

it is only my experience but it worths a try, response was immediate within days.unfortuantely i used gcmaf only the first 3 months and after the end of peg.maybe if i combo all 48weeks i could have achieved very low hbsag
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Gcmaf goleic is injections and sublingual, sublingual is weak but a member with hbsag 16iu/ml could make it undetectable without hbsab (so sometimes hbsag is detected).
he was on tdf+goleic+vit d3

he did not update so i dont know if he developped hbsab by now

i used goleic injected and nebulized, nebulized is reported as the most potent form of administration but i used it few times because it requires half a goleic vial which is quite expensive
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how long he took goleic with tdf to become hbs undetectable ? vit d3 was as high as iPTH allows or some regular dose like 10.000 ?
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Hi Friends,
I am also chronic b positive, Came to know bfore 2 years while donating blood. I am residing in India.

Recently I came to know about few ayurvedic/homeopathic clinics while searching on internet. Kindly let me know if anybody has idea about these clinics/medicines.

Dr Shangloo clinic

https://www.************/pages/Dr-Shangloos-Hepatitis-B-Homeopathic-Treatment/787904051286554
http://www.meerashangloohomeopathic.com/conference.php?act=conference_detail&con_id=38

Minhans homeopathy kerala

http://www.drbijuonline.com/index.php

Shushruta clinic new delhi for both Hep B and C

http://sushruta.com/
http://www.hepatitisccare.com/blog/

Kindly let me know your views on this if we can start their medicine or please also let me know if you have started medicine from
somewhere and Hbsag level going towards negative.
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Hi Friends,
I am also chronic b positive, Came to know bfore 2 years while donating blood. I am residing in India.

Recently I came to know about few ayurvedic/homeopathic clinics while searching on internet. Kindly let me know if anybody has idea about these clinics/medicines.

Dr Shangloo clinic

https://www.************/pages/Dr-Shangloos-Hepatitis-B-Homeopathic-Treatment/787904051286554
http://www.meerashangloohomeopathic.com/conference.php?act=conference_detail&con_id=38

Minhans homeopathy kerala

http://www.drbijuonline.com/index.php

Shushruta clinic new delhi for both Hep B and C

http://sushruta.com/
http://www.hepatitisccare.com/blog/

Kindly let me know your views on this if we can start their medicine or please also let me know if you have started medicine from
somewhere and Hbsag level going towards negative.
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wasted time and money
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i dont remember but it wan t long time, his problem was keeping it fully und without hbsab because on qualitative test he got pos few times

also strange he had nagalase about 2 and even when hbsag was undetectable nagalase was still about 1.5.maybe nagalase correlates with cccdna who knows

i dont remember his vit d dose
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shame that he didn't keept updating here
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i think he will come back posting if any news, he posted but not very close in time.when i got sometime i ll look if i get the post
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http://www.medhelp.org/posts/Hepatitis-B/Story-so-far/show/1979366#post_11681512

aberdeen577  

memeber who cleared hbsag but no hbsab by goleic gcmaf
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Thanks for finding a post. Nice result, but he had low HBsAg and used tdf for some time too. Hope he'll update status with HBsAb soon.
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yes we cannot tell anything for sure but he had low hbsag for many many years so the drop can be more from goleic than tdf.if Jalalkmohamed tries goleic too and he clears by few months we have more data for our guess, of course no scientific proof yet from this
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Hi Steff,
                 Right now i'm not in a position to order gcmaf in any forms  because of my financial problems.. it is costly.. i will try HBV vaccine. Just tell me what is the quantity of hbv vaccine i should use and what is the frequecy of dosages.
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it is best to wait and let pegintf keep working for at least 6-12 months, then as you have enough money the best choice is:

zadaxin+hbv vaccine

also try to contact these gcmaf producers, i dont know if the product can work as potent as goleic but they supply at very low price if you give feed back

http://www.gcmafresearch.com/
http://mafactive.com/
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pisa researchers use hbv vaccine, even monthly, after hbsag is undetectable if hbsab is not formed, i guess they wait at least 6 months post pegintf therapy

best wait and if gcmaf is supplied very low price from those companies this can be tried anytime
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http://www.mafactive.eu/store/p2/MAFX.html

ask them about this product, if it can be considered similar to goleic

http://www.mafactive.eu/store/p4/MAFActive_880_vitamin_D_binding_protein_in_solution.html

this product at 880ng of vdp should be the closer to goleic

i guess these products are gcmaf plus something like oleic acid because gcmaf alone can only be injected, it has no absorption by spray or sublingual.mafx is very low price at 50€ but you have to ask if it can have similar potency as goleic sublingual
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Hi Bro,
             I just got an updated report on my HbsAg it is 1.03 iu/ml as of today.
i will try HBV vaccine. Just tell me what is the quantity of hbv vaccine i should use and what is the frequecy of dosages.
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i have no idea if it ll work or worsen, it is used when hbsag is und, not when detectable

the frequency of dosages

we have zero indications about this.there are 2 trials made on transplanted patients with monthly doses but these patients have no hbsag

you might help vaccine response by using imiquimod cream at site of injection.there are some tips in an old post from studyforhope, i am not sure i remember correctly:
make vitd25oh at least 100ng/ml
put cream at site of injection about few hours before
make injection
put cream again after injection
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Hi Steff last week i had a test done this time i cud not get in iu/ml but i got is s/co and i was found negative. now please guide me on how to proceed
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I don't know whether you need to do anything. Maybe you can check your HBsAg and HBsAb qualitatively next time.
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Thanks Stephen
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