Aa
A
A
Close
Avatar universal
Is it possible to have HBsAg POSITIVE but Anti-HBc Total NEGATIVE?
Does somebody who is surface antigen positive (HBsAg positive) always have Anti-HBc Total positive also? Or can they also be Anti-HBc total negative?

Thanks
Cancel
3 Answers
Page 1 of 1
Avatar universal

hbcab igm is always negative on cronic hbv and if you mean hbcab igg negative it doens tmake a big difference because even if positive the titer is very low

what really matters on hbv infection is:
hbsag quant in iu/ml (i bet this is inversely correlated with nagalase enzyms)
hbvdna

all the rest is not very important since immune response is suppressed by hbsag and there are very low/undetectables antibodies anyway
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
Thanks for that but I didn't quite understand. Is it possible for a patient to be HBsAg POSITIVE but Anti-HBc Total NEGATIVE?
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Avatar universal

there are cases in hiv pos/aids patients with a lot of hbv mutants without hbcab and/or without hbsag too, that's due to many mutations of hbv with a very weak immune system

in any case variants are possible in hiv neg too, hbsag negative hbv is more common than hbcab negative

if you google hbcab negative hepatitis b you might find some articles
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Submit Comment
Your Answer
Avatar universal
Answer
Know how to answer? Tap here to leave your answer...
Answer
Submit Answer
A
A
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis B Community Resources
Top Hepatitis Answerers
Avatar m tn
Blank
stef2011
Italy
Avatar m tn
Blank
StephenCastlecrag
Australia
Avatar f tn
Blank
Royal36
Avatar m tn
Blank
Liverpatient
Avatar f tn
Blank
flyinsky
paris, France
Avatar m tn
Blank
studyforhope
Other