Aa
A
A
Close
Avatar universal
Is it possible to have HBsAg POSITIVE but Anti-HBc Total NEGATIVE?
Does somebody who is surface antigen positive (HBsAg positive) always have Anti-HBc Total positive also? Or can they also be Anti-HBc total negative?

Thanks
Cancel
3 Answers
Page 1 of 1
Avatar universal

hbcab igm is always negative on cronic hbv and if you mean hbcab igg negative it doens tmake a big difference because even if positive the titer is very low

what really matters on hbv infection is:
hbsag quant in iu/ml (i bet this is inversely correlated with nagalase enzyms)
hbvdna

all the rest is not very important since immune response is suppressed by hbsag and there are very low/undetectables antibodies anyway
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Avatar universal
Thanks for that but I didn't quite understand. Is it possible for a patient to be HBsAg POSITIVE but Anti-HBc Total NEGATIVE?
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Avatar universal

there are cases in hiv pos/aids patients with a lot of hbv mutants without hbcab and/or without hbsag too, that's due to many mutations of hbv with a very weak immune system

in any case variants are possible in hiv neg too, hbsag negative hbv is more common than hbcab negative

if you google hbcab negative hepatitis b you might find some articles
Comment
Cancel
Avatar universal
Comment
Comment
Submit Comment
Your Answer
Avatar universal
Answer
Know how to answer? Tap here to leave your answer...
Answer
Submit Answer
A
A
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis B Community Resources
RSS Expert Activity
233488 tn?1310696703
Blank
Marathon Running Done Over Many Yea...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
233488 tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
748543 tn?1463449675
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank
Top Hepatitis Answerers
Avatar universal
Blank
Italy
Avatar universal
Blank
Poland
Avatar universal
Blank
Australia
Avatar universal
Blank
Other
Avatar universal
Blank
Bangalore, India
Avatar universal
Blank