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Latest lab results
July 31, 2013

NFS (CBC) all values are normal
Creatinin 1.11 (0.6-1.4 mg/dl)
GGT 27.9 (3-35U/L)
Cholesterol, Total 4.60 (3.40-5.40 mmol/L)
SGOT (AST) 29.8 (6-25 U/L)
SGPT (ALT) 40.1 (3-30 U/L)
AFP 3.84 (< 20 ng/ml)
HBsAg quantitative (Roche) 416.8 IU/mL (< 0.05 IU/mL)
HBV-DNA TaqMan PCR Undetectable
Anti HCV Negative

Abdominal ultrasound is normal
Fibro scan 4.8 KPa (F0)

Was on Lamivudine for 5 years.

Eventually developed resistant to LAM. Liver biopsy showed F2 3 years ago.

Switched to Truvada (Tenofovir + Emtricitabine) for 3 years now. HBV-DNA undetectable after 3 months of Truvada.

My doctor just refered me to a study GS9620 from Gilead.

Should I go for this study?





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Avatar_universal
HBeAg has been POSITIVE ever since.
Forgot to test it this time.
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What was hbsag dynamic?
Could you post historical data for hbsag, dna, alt?
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Earlier HBsAg tests resulted POSITIVE ( > 250 IU/mL)
This time I changed to a different lab.

Have no idea what HBsAg dynamic is.
HBV-DNA undetectable for almost 3 years ( < 29 IU/mL)

AST, ALT have been normal for 3 years. The same with abominal ultrasound.

I monitor every 6 months.
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Avatar_universal
Try Interferon, your hbsag level is moderate so its worth a try if you can keep TDF and add IFN.

I think 9620 trial is for treatment naive patients. You can read more here
on clinicaltrials.gov
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I see now there is a trial with virologically surpressed patients. If you decide to participate please post back your HBSAG results and the final outcome as we are all very interested in new drugs
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