Long-term treatment with TAF associated with increased risk of serious liver disease

[Aduiski]

This might be one of the reasons why NUCs are not reducing drastically HCC cancer rates in us hep B chronic carriers

http://www.aidsmap.com/DAD-study-long-term-treatment-with-tenofovir-associated-with-increased-risk-of-serious-liver-disease/page/3028513/

Apparently, despite the fact that the TDF itself is harmful to the liver, its benefits outweigh its negative consequences...for those that really need the treatment with it. Hopefully TAF will improve this...

Sorry for the bad news guys...

[stef2011]

here you can see as hiv infected individuals develop liver diseases without any hbv infection.maybe hiv infection makes this or maybe their lifestyle or the many antivirals combo they take, i guess even those with no antivirals and hiv infection have liver problems

http://www.medpagetoday.com/resource-center/HIV/NASH/a/51621

A recent study by researchers from the National Institutes of Health (NIH) found high rates of liver disease among HIV infected adults with persistent, elevated aminotransferase levels while being treated with ART. 1 The study looked at patients who had elevated aspartate aminotransferase (AST) or alanine aminotransferase (ALT) levels higher than the upper limit of normal (ULN: AST >34 U/L or ALT >41 U/L) on at least 3 occasions over a period of 6 months or more. Eligible patients did not have evidence of viral hepatitis or other established causes of chronic liver disease and were candidates for liver biopsy.

full study in the link

[Aduiski]

nice one

[Jatashankar]

Yes, if the benefit outweighs the negative effects we'll have to continue it until taf comes with 1/10th reduction in dose and similarly sides.

[Aduiski]

TAF is coming out in few months in US...I am sure it won't be long until you have it in India

[stef2011]

if its hiv coinfected patients and it doesn t apply to us, they are totally different from our disease and they die anyway even if on antivirals, their disease is not hiv only but all the diseases that come with a weak immune system.

they get liver disease and kidneys disease and so many others while on antivirals

[Aduiski]

Doesn't looks like title can be changed. If a moderator sees it, pls change it.

[Aduiski]

Yes...meant to write TDF

[studyforhope]

The title of your posting is wrong, it should say TDF NOT TAF.

[Aduiski]

The authors acknowledge that their research has some possible limitations. They did not collect data on alcohol use, nor was information available on the use of potentially liver-toxic treatments for serious infections such as tuberculosis and PCP pneumonia.