Lovastatin inhibits the production of HBsAg in vitro but not virions secretion

[stef2011]

this is an artcle showing hbsag secretion inibition by lovastatin, it was the natural type not the synth like lovastatin in red yeast rice
it is an oold article and there has been no followup studies, today we have also the liposomes studies and simvastatin studies but again in vitro only.the only way to know how it works in vivo is try red yest rice or liposomes and measure hbsag because no drug makers are interested in making trials on this


http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WXR-4938MDK-C-1&_cdi=7165&_user=10&_pii=S0042682203004033&_origin=gateway&_coverDate=09/15/2003&_sk=996859998&view=c&wchp=dGLzVzb-zSkzS&md5=9b5d4ddaed025d65f36b096f07dc1574&ie=/sdarticle.pdf

[stef2011]

also liposomal vit c might be a good try combined with other supplements.1g lipo c should be equal to about 5g normal vit c.
it has no diarrea effect even at 10-15g daily


Summary# 24624
Keywords: CHOLESTEROL - Vitamin C
Reference: "Ascorbic Acid Induces a Favorable Lipoprotein Profile in Women," Gatto, Lissa, M., et al, Journal of the American College of Nutrition, 1996;15(2):154-158.
Summary: Ten women in a randomized, double-blind, crossover trial supplemented with vitamin C 1000 mg a day for 4 weeks followed by placebo and then the reverse was done. LDL cholesterol was found to be 16% lower at 4 weeks compared with baseline and the change in HDL cholesterol was positively associated with a change in plasma ascorbic acid. There was a significant decrease seen in the total cholesterol to HDL ratio at 2 weeks and the LDL-C to HDL-C ratio at 2 and 4 weeks. It appears that increasing ascorbic acid intake may have a beneficial effect on the lipoprotein profile in young women.


Summary# 46339
Topic: Supplementation with Vitamin C may Reduce LDL Cholesterol and Triglyceride Levels
Keywords: HYPERCHOLESTEROLEMIA, HYPERLIPIDEMIA, CARDIOVASCULAR DISEASE, CORONARY HEART DISEASE - Vitamin C, LDL Cholesterol, HDL Cholesterol, Triglycerides, Lipids, Fats
Reference: "Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials," McRae MP, Journal of Chiropractic Medicine, 2008; 7(2): 48-58. (Address: Marc P. McRae, Assistant Professor, Department of Physiology and Biochemistry, National University of Health Sciences, 200 East Roosevelt Rd, Lombard, IL 60148, USA. E-mail: ***@**** ).
Summary: In a meta-analysis of 13 randomized, controlled trials (published between 1970 and 2007) investigating the effect of vitamin C supplementation on LDL cholesterol, HDL cholesterol and triglyceride levels, supplementation with at least 500 mg/day vitamin C for a minimum of 4 weeks was found to significantly decrease LDL cholesterol (-7.9 mg/dL) and triglyceride (-20.1 mg/dL) levels and non-significantly increase HDL cholesterol by 1.1 mg/dL.

[stef2011]

Mechanisms for Cellular Cholesterol Transport:
http://physrev.physiology.org/content/86/4/1237.full.pdf+html

i have no time to read this now, it probably explains cellular cholesterol, i'll read it later today

[stef2011]

from all the articles i have found looks like what maters is cellular cholesterol which is quite different from serum cholesterol and i guess also very difficult to measure, i think the type of cholesterol to lower is ldl or the type of cholesterol from which ldl is made.hdl must not be lowered

it looks like only liposome which can enter cells directly can lower cellular cholesterol enough to make virus weak but as long as we dont try it in vivo we will not know.
lovastatin and simvastatin lower cellular cholesterol too but it is not known if enough to make virus weak

i have bought liposomal gluthatione and my sister will try it, it is a potent antioxidant with immune modulating activities if taken intravenous or by liposomes while normal gluthatione can be absorbed by stomach

in any case i think it is better try this once hbvdna is undetactable also because there is no direct effect on hbvdna and virions, hbvnda is probably lowered due to the hbsag lowering to low levels

it is also interesting to know that macrofages and cholesterol are linked too but i have not understood how, i guess that too much cholesterol lowers their function

[StephenCastlecrag]

Very interesting article. It seems lowering your cholesterol should help one's hbv. But what types of cholesterol?