We are all aware that low levels of vitamin D can cause weak bones. A recent study indicates that it could be associated with liver disease as well!
Researchers claim that low vitamin D could be one of the reasons behind the development of non-alcoholic fatty liver disease (NAFLD). NAFLD occurs due to accumulation of triglycerides in the liver cells.
Outpatients of suspected metabolic syndrome with normal liver enzymes, no excessive alcohol intake, negative for hepatitis B and hepatitis C, no cirrhosis or chronic liver disease were subjected to liver ultrasound to estimate the presence and degree of fatty liver disease. 25(OH) vitamin D levels were measured to estimate any deficiency of vitamin D.
The researchers found that patients with NAFLD had low levels of 25(OH) vitamin D. They also found that the lower 25(OH) vitamin D levels, the worse is the degree of fatty liver disease. This association was independent of other possible influencing factors like age, sex, triglycerides, HDL and fasting blood glucose levels.
Vitamin D suppresses fibroblast (cell from which connective tissue develops) proliferation and collagen production, thus acting as an immune-modulator. It also appears to have a beneficial effect in patients with hepatitis C on treatment with interferon.
Vitamin D normally plays a role in the metabolism of free fatty acids. Thus, the researchers suggest that in people with low vitamin D levels, the excess free fatty acids flow in the blood stream. These deposit in the liver, resulting in NAFLD. Vitamin D’s anti-inflammatory properties and reduction in insulin resistance could also play an important role.
Further studies are warranted to evaluate whether administration of vitamin D in patients with NAFLD could help to treat it, thus firmly establishing the association between fatty liver disease and vitamin D.
Read more: Low Vitamin D Levels Could Cause Liver Disease | MedIndia http://www.medindia.net/news/healthinfocus/Low-Vitamin-D-Levels-Could-Cause-Liver-Disease-88822-1.htm#ixzz1XaZ8QYbO
Having the vitamin D level up should help to normalize the glutathione level, based on the results of this study. This is one more piece of information that supports the advisability of getting vitamin D up. As you may know, Dr. John Cannell a few years ago found that giving his patients 5,000 IU per day of vitamin D3 caused all 30 of them not to get the flu when it ran through Atascadero State Hospital in California, where he works. Perhaps this effect on CBS is connected with the protection against flu, because raising glutathione will give better Th1 immune response, which is the type of response needed against viruses. As you may also know, the RDA committee of the Institute of Medicine has recently raised their recommendation for vitamin D intake, but they brought it up only to 600 IU per day. This may not be enough for most people to get them into the optimum range of vitamin D levels. Vitamin D is toxic at very high dosages, perhaps above about 10,000 IU on a steady basis. There does not seem to be good data on the toxic levels so far. Some people take higher than this amount for short times to get their levels up, and this seems to be O.K. It's a good idea to work with your physician and have your vitamin D level measured periodically when supplementing at high dosages. I'm trying to keep my vitamin D level above 50 ng/ml. More information is available on vitamin D at www.vitamindcouncil.org.
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