I've started interferon 5 weeks ago, I will try to keep updating in this thread and put related questions here.
HBV DNA 700 IU (few months earlier 5600 so fluctuating)
HBsAg 13.000 IU
Fibroscan 5,8 F1/S0
week 2: ALT 90
week 5: ALT 245
My doctor said last ALT is from one side good (cleaning infected cells) but from other side he's worring that it has raised so fast. I have to check it in two weeks. He said if it will raise to 400 he will decrease peginf dose to 135mcg cuz he's worring that fulminant hepatitis may occure.
I know Stef, but doctor's dont like when their patients and reputation die :) so they prefer to be cautious. I hope ALT won't rise more and there won't be a need to cut a dose.
Btw, does coffee can cause some ALT increase? There is a study which proved that it boosted peginf response perceptibly in hcv therapies, it also helps liver generally so I would prefer don't cut it.
I've used black seed before peginf, but for now I've cut some of supplements. it's not good to use too much antioxidoxants during inteferon treatment, althought some are needed.
No, I haven't been treated before. There's no reason to panick, yet ;) I had ALT test in a few days and hope it will be high enough to clear but not dangerous. I will be updating in this thread to keep order.
Ya rite, I did my thyroid and hbsag today after 16shots,
Thyroid is normal hbsag result tommorow. 4week gap will show some changes I think hopefully reduction. If no Change I'll shift to peg 2a and see for next 8weeks and then stop if waste response comes.
Now we can only guess, high alt is good but there may be different reasons of high alt on peginf. Quantitive HBsAg at 12 and 24 weeks is the only way to give some real odds. Of course cure is my target :)
I feel my liver a bit from time to time, but it's not the pain just some feeling. After first shoots I had some fever and pain of the leg muscles from time to time or headache, but nothing serious.
If your doctor treated only 10 patients with peginf in his whole carrier he's not very experienced in using this, maybe consult someone else too if consider using it in a future.
As I know my clinic does those tests in separate labs and dna is after 2 weeks and hbsag 2-3 weeks because its send to Berlin.
I do gym 2-3 times a week, not maximum weights but not smallest ones. So I guess we may say side effects are very mild. Or maybe they are mild because I do some exercise, its possible too. Recently, I fell only some muscle pains.
There are some mild sides but nothing very serious and if something happens like nausea it passes quite quickly. It's week 14 now so it may change too.
My concern now is low neutrophils 0,83, other params are low but stable.
Thanks for support Mike :)
stef2011,could you please suggest me at what time should we take etv 0.5 along with tdf 300.My doc. has prescribed etv+tdf combo for my mother....is it necessary to take them at the same time or can they be taken separately at a suitable point of time over the day?My mom takes etv 0.5, 2 hrs before breakfast,should she take tdf at that time or some other time?tdf is to be taken before/after meals?Thanks in advance......
Ok,thank you..... actually i got confused because my doc asked my mom to take both the medicines together at the same time in the morning with empty stomach which i think might be risky in empty stmach.....that's why needed to clarify if they can be taken separately at different point of time.
damn so bad we have so many ignorant doctors around, when you see it again tell him he is wrong, tdf need food for best absorption and it is not negligible especially in your case where full potency tdf is needed and might not fully work because etv mutants plus lam mutants can be too much with some secondary mutations
Thanks for your support guys ! :)
Week 16 results:
ALT 155 similar like before
Neutrophils went up a little to 1,08
Hemoglobin first time a little below the norm.
Rest results no change in compare to prev ones.
i though it was week 24!if it is week 16th this is a big, huge response....between week 12 and 24 on hbeag neg you even see an increase of hbsag at first and the decline on 24week and on
so please confirm it is hbsag at 16weeks?we may see an increadible response then at week 24, just to compare to other studies in logs you had a 1 log decline at week 16th, if you see 1,5log decline at week 24 we may see very low hbsag by week 48
i am just reading it all again:
hbsag week 13 1log decline, from 13.000iu/ml to 7500iu/ml, man this is a huge response not just a little because you have hbeag neg and genotype D the hbsag at week 12 is not even conclusive, for genotype D you need to see decline at week 24 to be sure of response but you had it already and it is 1 log....
the decline is not exactly 1 log but it doesn t matter, what it matters is decline and continuous and that is about week 12 which is not indicative on genotype D hbeag neg...prediction on hbsag loss at week 48 will come from the values of hbsag at week 24
i share your same genotype and hbeag neg, you can be sure i read all studies and statistics on peg mono and it s huge response because you have to take into account:
high baseline hbsag
genotype D, the hardest genotype on hbsag
HBsAg result is from week 13, it's 0,25 log decrease, not impresive but also not terrible cuz I know some people have even increse.
I dont know my genotype. In Poland 85% is A and 15% is D.
Since ALT is still increased to 150 in week 16 its worth to continue peginf.
definitely a response, mild if it is geno A very strong if it is D
is your family from caucasian blonds or possibly from souther europe caucasians...i mean if your parents and granparents are all from south europe or there is immigration from mediterranean area it could be D, if all from northern europe A
As i found in some websites that high intake of fats favours absorption of tdf, is that true?Did you have normal diet before taking tdf or was there some restrictions? These doctors do not make us aware of the proper guidelines....they hardly give us 3-4 mins for each visit.
While we all desire a miracle, your results are very good indeed.
The severity of your hep is going down...and so are your chances of hcc.
If you can get it bellow 1000 your chances of getting hcc will be reduced to minimum.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.