NBV DNA result: What does this mean

[Dimidine]

I tested positive October last year and I have been doing LFTs, almost on monthly basis. I have also done USS like four times, the most recent being this morning. Scan results is showing 'clean liver and kidney' to use the Dr's word.

However, I just did NBV DNA for teh first time and the NBV viral load is said to be 20,682. How serious is this? Do I need treatment yet? What can be done to make it go down. I count on your enlightenment, as usual, please.

[Dimidine]

What suggests in the reports up there that I am in inactive phase or inactive carrier. Pls educate me more.

[Dimidine]

Tanx so much. BRB for more info

[stef2011]

I thot it's a positive or negative thing?
it was, now it is an important test as much as hbvdna although US, UK and canada are not updated and it is not easy to find labs for this test, the best one is abbott hbsag quantification test in iu/ml with 1:1000 diluition for values higher than 3 logs.
in europe and asia is much eaiser to find it

Hepatitis B core IgM Ab Negative, this is needed quantitatively, actually all tests are better quantitatively although more expensive, quantity can give much more info

anyway your sitation is pretty clear, you are in inactive phase or inactive carrier, the therapy with best results are interferon and alinia although i do not suggest interferon due to poor results in your situation and heavy sides

as i said earlier you might try off label alinia or just monitor, you don't have any active disease although virus is present in your liver and blood your immune system is able to reduce replication and liver damage

[Dimidine]

pls can u outline the right tests I should do now pls. I appear to be at a loss. I thought HBV DNA shoudl be the next.

Is Hbsag a quantity thing? I thot it's a positive or negative thing?

Here is teh first test I did in October last year, how relevant?
HEPATITIS B VIRUS  TEST                       RESULT     REFERENCE RANGE          
HBsAb                                                             0        mIU/ml
HBEag                                                    Negative
HBEab                                                    Positive
Hepatitis B core IgM Ab                            Negative

[stef2011]

AST  41 IU/L
ALT  19 IU/L
this needs to be verified by doctor, liver damage by hepatitis has a specific alt/ast ratio with alt always higher than alt.higer ast is usually related to other organs or illnees not hbv

alt 19 perfectly normal (new normal values for men less than 30), you are missing sieroproteins that are very very important and might show other diseases not only hbv or liver disease

you are also missing hbsag quantity to confirm if active or inactive carrier but at the moment you are in inactive phase anyway and ll other markers hbe, hbeab, hbc, hbeab, hbcab Igm quantity to confirm inactive state

if you are totally inactive confirmed by low hbsag and hbe negative/hbeab positive you might monitor every 6 months or try off label alinia (nitazoxanide) and make hbsag negative in 1-2years therapy

[stef2011]

you made wrong tests too often for nothing i think, hbv markers are the most important with hbvdna pcr (all antigens and antibodies quantitatively can help a lot if and if possible all in iu/ml except hbe,hbc) made more often
if you find hbsag <500-1000iu/ml with normal alt/ast and hbe negative you are inactive carrier

the tests you have done are for liver damage and they are ok every 6 months because liver damage takes years to happen and according to hbvmarkers can never happen

[Dimidine]

MORE INFO:
Here is my LFT result:
AST  41 IU/L
ALT  19 IU/L
GGT   31 IU/L
ALK. PHOS. 20


HBV DNA 20,672 copies/ml