Thanks for the kind reply. I believe I live liver friendly live. I never drink alcohol, no smoking and try to not eat unhealthy diet. I am not fat (W: 65 Kg H: 5.6 Feet). I walk 40 minutes everyday. The one thing that I am not maintaining is timely sleep. I am normally sleep at 2-3 AM cause I work from online in a USA software firm.
stefano170669 , could you please tell about the case hbsag quantification? I have also checked HBsAg which result index was 290 (out of 1)
that's not quantification, it is reactive/non reactive qualitative test, quantification can be made by abbott architet only with unit in iu/ml
if you are liver friendly it might be virus left in the liver or hbvdna assay not sensitive enough, what is the lowest range detectable in your hbvdna test?
since you are hbe negative you might combo entecavir with alinia, see our posts about it.By alinia you will lower hbsag and maybe eradicate hbv, lower hbvdna to the lowest and prevent any possible resistance, of course hbv eradication by entecavir only is almost zero it can only control it
just put nitazoxanide or alinia in the search of hbv community and you will find all the links about alinia, it is too long to repost again, you will proably find all them in this long post too
the problem of all us hbv carriers is there is no drug effective on hbsag, only interferon is but very poor, and alinia looks like the most potent on hbsag (hbsag eradication means hbv eradication) in combo with entecavir or tenofovir or interferon (the most potent interferon combo and alinia combo from our small alinia group)
post messed up again (looks like firefox doesn t work well with medhelp)
alinia looks like the most potent on hbsag used in combination with entecavir or tenofovir or interferon, from our small group experience the most potent combo is interferon+alinia or entecavir+alinia (alinia dose 1.5g or 2g daily, slower or no results on 1g daily)
HBDNA: Not Detected
what is the sensibility?fo alt to be normal hbvdna must become less than 6iu/ml and most assays do not detect less than 20iu/ml
is your diet, wheight, life all healthy?
the most easy way to understand why alt is high is:
exclude bad diet, cholesterol, fat be the reason
exclude hbv by:
checking hbvdna by an assay with very high sensibility like 6iu/ml and at the same time check hbsag quantity and see if increasing or decreasing, in general alt gets at 30-40 range or lower after being hbvdna fully und for 2-3 months when etv or tnf therapy is taken
etv might be not strong enough to suppress hbv then.
you have 2 choices add tenofovir+entecavir and after a combo of at least 5-6months choose if to go on tnf monotherapy.tnf is more potent and has no resiatnce
or add nizonide500 (nitazoxanide) to entecavir
i added ntz to etv this both to prevent resistance and boost hbvdna decline because at 5th nmonth of etv monotherapy it was still detactable, i was also hoping it was effective on hbsag lowering but at first i added to prevent resistance
after adding ntz decline was faster and i had less than 50iu/ml before 24 weeks, lower than 20iu/ml by 6th month and undetactable by 7th month
it just came back detactable to 21iu/ml when i lowered ntz in sep 2010 to 1g for a week since then i try to stay on 1,5-2g daily and nevr go lower than that
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