Normal vitamin D levels are associated with spontaneous hepatitis B surface antigen seroclearance.
Mahamid M, Nseir W, Abu Elhija O, Shteingart S, Mahamid A, Smamra M, Koslowsky B.
Mahmud Mahamid, Shimon Shteingart, Mosab Smamra, Benjamin Koslowsky, Digestive Disease Institute, Shaare Zedek Medical Center, Jerusalem 93722, Israel.
To investigate a possible association between serum vitamin D levels and spontaneous hepatitis B surface antigen (HBsAg) seroclearance.
Fifty-three patients diagnosed with chronic inactive hepatitis B and spontaneous HBsAg seroclearance were followed up in two Israeli liver units between 2007 and 2012. This retrospective study reviewed medical charts of all the patients, extracting demographic, serological and vitamin D rates in the serum, as well as medical conditions and current medical therapy. Spontaneous HBsAg seroclearance was defined as the loss of serum HBsAg indefinitely. Vitamin D levels were compared to all patients who underwent spontaneous HBsAg seroclearance.
Out of the 53 patients who underwent hepatitis B antigen seroclearance, 44 patients (83%) had normal levels of 25-hydroxyvitamin vitamin D compared to 9 patients (17%) who had below normal levels. Multivariate analysis showed that age (> 35 years) OR = 1.7 (95%CI: 1.25-2.8, P = 0.05), serum vitamin D levels (> 20 ng/mL) OR = 2.6 (95%CI: 2.4-3.2, P = 0.02), hepatitis B e antigen negativity OR = 2.1 (95%CI: 2.2-3.1, P = 0.02), low viral load (hepatitis B virus DNA 8 years) OR = 1.6 (95%CI: 1.15-2.6, P = 0.04) were also associated with spontaneous HBsAg seroclearance.
We found a strong correlation between normal vitamin D levels and spontaneous HBsAg seroclearance.
i ll think i ll monitor hbsag closely just to be sure not to have 0.5log decline by following months and be out of pegintf prescription
my sister will keep taking tdf and vit d until 165ng/ml and gcmaf so we may see if hbsag keeps the declinign trend, other members like rome may also confirm if these high serum levels of vit d work like this
stef,what could be reason that from 60000 it reached to base value 100000 in just 3 weeks time, is it some amount of immune system response as lymphocyte were in upper range at the time of hbsag decrease, is there any chances that in some point of time it can come down to thousand ranges.any comment. cant switch ,i have to be on baraclude.
It can be as high as high250k it is normal on hbe pos, etv is not working or too weak that is the problem.pegintf add on may help, wait another year on etc plus high vit d, maybe try gcmaf and then if no effect add pegintf
Of course Stef knows better, vut for me your figures look rather strange, i have never met a figurer higher than 20000iu/ml for hbsag. I would retest in a different lab and make sure about the dilution and units. What is your VL, hbe positive?
immune biotech has made new gcmaf compounds for macrophages activation and they just found vdr activation by cellular membrane is possible by gcmaf+oleic acid+vitamin d
full text can be downloaded for free
the new molecules have oleic acid attached to gcmaf and are available as liposomal for direct liver delivery, do you think macrophges activation in the liver is better than activation of monocytes in general circulation for hbv infection?
i don t know if cancer applies to our scenario, for example delivering gcmaf inside tumors is useless because macrophages inside tumors cannot be activated (they tried and didn t work on tumor) or have other activity problems, can we have the same type of immune suppression by hbv in the liver so that it is best to activate monocytes in general circulation whichin turn will reach the liver for immune activity as kupffer cells?
or in the end we should just try the liposomal and see if it does any difference?
this research group is getting very very interesting in cancer research, they got front page of oncology immunology this month
yes it is gcmaf plus oleic acid and it will attach circulating vitamin d so that t can attach to the vdr receptor
is it taken in combination with gcmaf and extra vit D?
yes good levels of circulating vit d are needed to attach the vdr receptor
How to monitor if it has any effect?
by the nagalase level, when it falls below 0.6 activation of macrophages is the same as healthy persons and maybe this will have an effect on hbv immunity too by lowering hbsag quantity
my guess is:
making vit d very high like 165ng/ml even without gcmaf may increase vdr attachment anyway.
it is obvious that the maxium effect is by having both gcmaf and vit d at levels like if there is no inhibition by virus, so nagalase less than 0.6 (there is no commercial test for gcmaf quantity available so we have to check nagalase which will refelct gcmaf quant) and vit d around 100ng/ml
i just saw that new labs are available in many european countires:
Prof. Dr. med. M. Kramer
Facharzt für Laboratoriumsmedizin Mönchhofstrasse
52 69120 Heidelberg
T: +49 (0) 6221 434 0963
M: +49 (0) 171 956 3808
F: +49 (0) 6221 434 0964
Dr. Emar F. Vogelaar
European Laboratory of Nutrients
3981 LA Bunnik
Phone: +31 30 2871492
Fax: +31 30 2802688
we dont know yet, only few memebers are using it and for little time.having a normal nagalase is of course better for immune system but it is not sure if it can have any impact on hbv clearance
the most potent one is mafx5 by injections, after this a less potent form is stabilized vitamin d taken orally
i think the liposomal type might be the best for us, but they said they dont have it available yet.liposomes go straight inside liver cells so gcmaf would go where nagalase is highest.....these are anyway just guesses because we dont know the level of immune suppression inside the liver and if macrophages are able to activate there
the other gcmaf forms go in general blood circulation so they activate macrophages and monocytes there that might move to the liver later on
Maybe I will do the nagalase test to see if I need it. The other thing bothering me about this is the Vit D: they say it is required, but I don't want to supplement high dose D3. Maybe eating more sardines and cofactors will do the trick :). The other things they reccomend (vit C, no wheat, no sugar, root canals removal...) I like a lot.
What did you do to start gcmaf?...Did you consult with one of their doctors?
Also, why do you take so much D3?...on the gcmaf site they say: "GcMAF needs normal levels of vitamin D (40ng/ml+) to fully function." ...so a little over 40 should be enough. And in the study of this topic they consider normal Vit D level > 30ng ...I see you go over 100 ng/ml?...Is it really needed? I wouldn't take so much if there is no need, you never know what harm (maybe) can that do.
An Evaluation of the Vitamin D3 Content in Fish: Is the Vitamin D Content Adequate to Satisfy the Dietary Requirement for Vitamin D?
It has been suggested by those who have little knowledge of human nutrition and little expertise in the field of vitamin D that everyone can obtain enough of their vitamin D requirement from their diet and that any unprotected sun exposure should be avoided (5). However, most experts agree that 1,000 IU of vitamin D3 is required if there is no exposure to sunlight (1–3, 6,7). It has been assumed that fish, especially oily fish such as salmon, mackerel and blue fish are excellent sources of vitamin D3. However, our analysis of the vitamin D content in a variety of fish species that were thought to contain an adequate amount of vitamin D did not have an amount of vitamin D that is listed in food charts. There needs to be a reevaluation of the vitamin D content in foods that have been traditionally recommended as good sources of naturally occurring vitamin D.
"my nagalase was 6.7 totally lost macrophages activation and i was immune suppressed similar to a aids patient (flus and candida chronic)"...It is you on gcmaf.eu site (an italian patient with 6.7 nagalase regressed cirrhosis)?...Good for you getting better!
"fish is poisoned of mercury and other metals." ...small fish (sardines) contains the least (plus it is a pill less, + you get selenium, fatty acids). Is natural food. But some people prefer pills.
"as a reference farmers under the sun reach naturally 60-140ng/ml of vitd25oh"...Yes, this is the natural way:
"When exposed to sunshine, your skin also synthesizes vitamin D3 sulfate. This form of vitamin D is water soluble, unlike oral vitamin D3 supplements, which is unsulfated. The water-soluble form can travel freely in your bloodstream, whereas the unsulfated form needs LDL (the so-called "bad" cholesterol) as a vehicle of transport. According to Dr. Stephanie Seneff, there's reason to believe that many of the profound benefits of vitamin D are actually due to the vitamin D sulfate. As a result, she suspects that the oral non-sulfated form of vitamin D might not provide all of the same benefits, because it cannot be converted to vitamin D sulfate"
For info, there is also homeopatic gcmaf: http://www.biopure.eu/english/webshop/frequenzmittel/homeo-k/homeo-kmaf-50ml.php .
For info, there is also homeopatic gcmaf: http://www.biopure.eu/english/webshop/frequenzmittel/homeo-k/homeo-kmaf-50ml.php .
probably scum and cannot be reliable, gcmaf.eu is the only lab in the world producing for all the human trials and about 40 university research, it is crazy to use other sources of such a compound especially for the fact that is blood extracted
another reliable source is from the university of japan, the ones who discovered gcmaf but they are not using the purified form and at this time i d not consider japan as reliable being fukushima radiation tottally out of control
sun doesn t work to produce vitamin d on people with chronic diseases, i tried already myself, you can get to about 30-40ng/ml, hbv lowers it
"probably scum and cannot be reliable, gcmaf.eu is the only lab in the world producing for all the human trials and about 40 university research, it is crazy to use other sources of such a compound especially for the fact that is blood extracted" ...you do have a point there.
"on chronic viral infections:
vitd 25oh low
vit d 1.25 high
nagalase high" ...that is one of the problems (according to mpkb.org) why I don't take D3. In chronic disease, the body converts 25oh in 1.25 resulting in very high 1.25 that starts occuping other receptors (thyroid, test,.. ) without activating them. You take a high dose D3 since long time ago. Do you do all test blood, including thyroid etc and everything is OK?...Thanks!
I think of using benicar as a test (this one directly activates the VDR, according to mpkb.org). These guys were invited to write a chapter in Craig Venter's book (the genius behind the human genome)...they must be at least partiall right about what they are saying. Plus I have some autoimmune symptoms (little hair loss and vitiligo).
Also, it seems Boron increases D3:
"In a recent study, 90% of Vitamin D deficient patients who took a 6mg boron supplement experienced a 24% increase in Vitamin D-3 serum levels in 60-days."
Also, iodine+b2+b3 seems to decrease D3 (in chronic diseased patients). I always wondered why I get cold/flu like symptoms when I take high dose of iodine. Maybe it is related to vit D, I will take it with D next time to see the result: http://www.optimox.com/pics/Iodine/IOD-21/IOD_21.htm
"sun doesn t work to produce vitamin d on people with chronic diseases, i tried already myself, you can get to about 30-40ng/ml, hbv lowers it" ...Why would hbv lower vit D produced by the sun, but not the one in a pill?...doesn't make sense to me. do you know why?
everything is ok with blood tests and d3 plus which had also boron, k1, k2 and magensium looks making much higher d than normal d3 supplements
the chronic infections, not only hbv but aso autism, MS, CFS, hcv and all others lower vitamin d whatever the source, be it sun or supplements, so the dose needed is super high compared to healthy people.in my case i could do nothing by 4000-5000iu daily plus hours of sun, just reached 30-40ng/ml.only a dose of 10.000iu daily made it to 50-60ng/ml while 20.000iu made it 100ng/ml
here are some charts but sick people may need even more
"the chronic infections, not only hbv but aso autism, MS, CFS, hcv and all others lower vitamin d..."
Actually, they don't lower vitamin D directly. What i understood is: the body (seeing a lot of pathogens inside it) converts all vit D in 1.25d in order to activate the VDR (that releases antimicrobial/antiviral). That is why vit D gets low. In cases like this, taking a lot of D3 will make 1.25D levels go very high and because this high concentration of 1.25d in the blood it is possible that other receptor (thyroid, estrogen..) will be blocked by 1.25d (leading to other health problems). This is MP theory, I am not saying is what happens in reality. Their solution is to take benicar (which activates the VDR) so no need for very high dose D3.
Just curios: Did you ever tried high dose iodine?...I always react badly to it (flu/cold symptoms) and I just found out recently it lowers D3 (in chronic diseased people)
this is in vitro so only our experience may show this in vivo but since all this is healthy it does make sense to change our diet to have these foods or natural supplements in
Immune system improvement by vitamin D is boosted by resveratrol and blueberries – Sept 2013
Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids
Molecular Nutrition & Food Research, Vol. 57 Issue 9
Chunxiao Guo 1,2,†,
Brian Sinnott 1,2,†,
Brenda Niu 4,
Malcolm B. Lowry 1,3,
Mary L. Fantacone 1,2,
Adrian F. Gombart 1,2, adrian.***@****
1 Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
2 Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, USA
3 Department of Microbiology, Oregon State University, Corvallis, OR, USA
4 School of Medicine, Oregon Health Sciences University, Portland, OR, USA
† These authors contributed equally to this work.
Scope: The cathelicidin antimicrobial peptide (CAMP) gene is induced by 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), lithocholic acid, curcumin, nicotinamide, and butyrate. Discovering additional small molecules that regulate its expression will identify new molecular mechanisms involved in CAMP regulation and increase understanding of how diet and nutrition can improve immune function.
Methods and results: We discovered that two stilbenoids, resveratrol and pterostilbene, induced CAMP promoter-luciferase expression. Synergistic activation was observed when either stilbenoid was combined with 1α,25(OH)2D3. Both stilbenoids increased CAMP mRNA and protein levels in the monocyte cell line U937 and synergy was observed in both U937 and the keratinocyte cell line, HaCaT. Inhibition of resveratrol targets sirtuin-1, cyclic AMP production and the c-Jun N-terminal, phosphoinositide 3 and AMP-activated kinases did not block induction of CAMP by resveratrol or synergy with 1α,25(OH)2D3. Nevertheless, inhibition of the extracellular signal regulated 1/2 and p38 mitogen-activated protein kinases, increased CAMP gene expression in combination with 1α,25(OH)2D3 suggesting that inhibition of these kinases by resveratrol may explain, in part, its synergy with vitamin D.
Conclusion: Our findings demonstrate for the first time that stilbenoid compounds may have the potential to boost the innate immune response by increasing CAMP gene expression, particularly in combination with 1α,25(OH)2D3.
just be sure to supplement k2m7. take minimum of 100mcg of vit k2m7 for every 10.000iu vit d. this is absolutely necessary
stef might be the only knowledgeable guy who is here everyday, and he is giving you guys tremendous advice on vit d, and you are all ignoring it. vit d has shown tremendous research results, and it's cheap as dirt.
more of you should be taking 20.000iu/day. get your vit d levels up to 100ng/ml.
what me and my sister noticed is hbsag decline while vitd25oh was around 80-90ng/ml while relapse or stable at 50-60ng/ml
in any way we target 165ng/ml while on gcmaf now we want to see clear if there is cotinuous and clear decline on these high levels kept stable
it is only me on blueberries and reservatrol, my sister is not
yes actually me, my sister took 5000 or 10000 for years now but to get to 100ng/ml and more at least 20.000iu daily are needed and both cofactors and no diaries in diet are needed to stay safe aiming at 100-165ng/ml
Vitd25oh is 75, when it was 60 hbsag were down and it went up together with vitd growing up, so I do not see any correlation. My creatine also was at the upper limit with 10000iu od D3 daily so I decided to get d3 down to 5000iu to see if 25oh will hold. Studyforhope by the way recommended to stay at around 70 with 25oh....
This oat drink that you take, have you tried to make yogurt with it?
since i am on gcmaf and this high vit d i dont have any health issue at all so i was not thinking about yogurt
as to gcmaf a researcher just confirmed me that liposomal gcmaf, when available, would be the best form for hbv or liver cancer.as an alternative goleic oral drops was indicated as better than stabilized vitamin d or mafx5 injections
I do take three caps of biotech d3, but it is 5000iu read the label carefully
i mean they indicate as dosage 3 caps per day, every cap is 5000iu so it makes a total of 15.000iu.so my guess is that they know cofactors allow higher dose safely
I think You can make yogurt from anything you just need right bacteria, I was doing yogurt from soja milk myself why you can not make it from oak juice...?
i can t make yogurt now anyway, i am too busy, as long as the hbsag keeps with this decline i am ok and hopefully will add pegintf when 1500iu/ml
Is gcmaf useless unless you have 25oh at 165ng/ml?
no gcmaf just needs normal levels of vitd25oh like >40ng/ml but the more vitd25oh the more response.this was true with the normal gcmaf, these new types might have gcmaf incorporated already with all nutrients needed to attach to vdr, so you can go on with the normal vitamin levels within 100ng/ml range
it is says serving size = 3 capsules, then it says amount per serving = 5000iU
it means that there are 5000iU in 3 caps.
see the back label.
If you want 15000iU you need 9 caps a day = 3 servings.
As for making the yogurt it does not take more time than shopping for it you put it into the yogurt maker and press the button, it 1 min max. And you get a real product without any preservatives and with alive bacteria. All you need is a stock of organic soya milk.
On the side note folks. As we all can see heaving a healthy immune system is key to control or clear hbv.
Macrophage activation equals a good thing. NUCs actually cause macrophage toxicity. Which begs a question why prescribe them?
What Stefan here shares is great information. It works. But Bigpharma knows this too. How hbv works and how to knock it out. But instead they steer this research sideways in the wrong direction. To continue treat people life long rather then cure them. Cure for hbv is immune system.
googling "vdr receptor liver" there are many many studies about vdr receptor which is expressed very very much in the liver and fibrosis, some studies proposed vdr receptor agonists as treatment for liver fibrosis
by the way "stabilized vitamin d" can be used as IM too but low dose due to its potency, i tried it already 0.1ml and no sides
i also saw this news:
the letter published:
i always thought cysts are no trouble at all although they may become tumors while it may be not so rare.....i had a big cyst 14mm appeared on US in 2011 and stable until 2013, then i restarted the new type of gcmaf (mafx5) which is even more pure than the previous and last US on sept the cyst is 8.5mm
all this makes me wonder:
it is best not to have any cyst in the liver indeed
it is best to have fully normal nagalase less than 0.6 since we are at increased risk of liver cancer
probably the improved immune control in the liver is clearing the cyst now, maybe due to gcmaf but in any case whatever did it what matters is the cyst is clearing
also flu viruses produce nagalase so if you make the test rightafter a flu the test might show increased values not due to hbv infection or other chronic infections or small tumors not detectable yet by other means, i suggest wait a few weeks after the flu is gone
feedback about "stabilized vitamin d" supplement subcutaneous injection (gcmaf plus nutrients to attach to vdr directly), started with 1ml one day and 1.6ml the following day:
i notice similar increased inflammation as when i did imiquimod, had a mild lip herpes, it is very similar but milder and no fever
i also had a bad skin rush on arms and legs with terrible itch since 3-4 weeks and resolving today, it started with mafx5.it was not severe and looked like this on legs, arms and body were very little red dots with no itch
the rush looked like this and itch was bad on legs and arms:
test results ready and me there is 99,9% correlaton between hbsag and vitd25oh, at least for me.
vitd25oh dropped very much since i was taking 8000iu daily instead of 20.000iu as thought due to the bad d3 plus from biotech content indications, the good thing of all this is we now know 100% about this correlation and i also decided to go for 40.000iu d3 daily because there is really no other way to make it more than 100-165ng/ml and stable
vitd25oh dropped to 70ng/ml
hbsag increased to 3812iu/ml
the 10th of july i had exactly same results:
the other good thing is it looks like decline of hbsag is very fast responding to the increase of vitd25oh>100ng/ml
Can you put together 25 oh, d3 intake and hbsag historical data as you did before on a chart maybe?
I will post mine.when I gpt my tests.
I have a feeling that hbsag reacts on a change rather than on a level. I had similar pattern hbsad decreased verry well but afterwards it jumped back to the level even higher than it was. And I did not decrease vit d intake.
The only thing that i need to mention is that I was getting the UV from the sun about 1 hour a day, after a month I got a sun tun the skin became very dark, this could result in decrease of 25 oh production in the skin and this is very serious amount of D3 15 min at the sun = 20000 iu of d3, but with hbv it is probably lower.
Started taking ampouls of mix milkthistle + black radish= 1st july three weeks later jessner and kanof was noticeable on my skin but with no itchiness as experienced every year from 2005 to 2010 - from 2010 to july2013 this condition vanished and discovered Hep b on 12.12.12 the question at this stage which one occured first JKD or Hep B?
The low flare of jessner kanof that started on july lasted until end of August.
September first started taking vitd3 equvalent of 5000ui per day. Two weeks later huge flare nasty one all over my body except face itching like hell.
Please use googl translation.
Pénétration dans les parties profondes du derme d'une variété de globules blancs, les lymphocytes T. et essentiellement les lymphocytes T. suppresseurs, cytotoxiques. Les lymphocytes B sont absents. Ce détail a été en évidence grâce au marquage des cellules (immunocytologie).
As suspected in previous post cell B got stronger on 2010 until 2013 by stealing element from cell T that made this latter weak resulting in hep b.
After the first jesner and kanof flare the oposite occurred for both cells B weak and T strong and my August test prove it by lowering HBV DNA from 200 ui/ml to 60 Ui/ml.
This to be confirmed on 10 th october test, which i suspect the HBV dna to be und after the huge flare of jessner and kanof I am experiencing at present all over my body. TBC
What causes JKD essentially remains unknown, but it seems that a dysregulation of the immune system may play a role, probably an intermediate, between the true cause and the manifestation of the disorder. The association with B. burgdorferi infection and the drug GLAT which is an immunomodulator supports this hypothesis.
Soflab exemple: third pic from the left first row:
my sister had also a huge rise in platlets she never had which correlates with liver repair and stemcells:
before gcmaf 184
after gcmaf 259
she's on gcmaf only 7 weeks, we will have a fibroscan to confirm if fibrosis regressed so fast after 12weeks, baseline fibroscan 8.7kpa, on google i have found many studies which correlates vdr receptor agonists and fibrosis due to any pathology
it never changed so i didn t check it but they have other tests at the hospital for it too and they would have told me if there were any change
the only thing that changed my creatinine was imiquimod suppository 25mg daily, i tried it for 7 days but sides were not tollerable.it lowered hbsag about 800iu/ml in 1week.
hopefully pegintf will have same effect on me with less sides
sorry i forgot....too many tests, i had creatinine clearance few weeks ago and my kidneys improved since baseline to over normal kidneys, they filter more than everage kidneys:
creatinine clearance from 108 to 144 (rane 90-135)
urine calcium 150 (max range is 300)
serum creatinine also decreasing from usual 0.95 to 0.83, actually almost never had it so low, just one time i had it 0.8 years ago
so the overall picture is improvment on all aspects
I had posted my levels two months ago if you remember(with my ultra high vit d level). I had been suggested to give up vit-d supplements by my doctor.After about two months I've rechecked my levels.
Old and new values are as follows as of Aug 2013 - Oct 2013
Vit d3: 162.2 ug/L - 36 ug/L (=ng/ml) (very steep decline though in summer)
Blood Calcium: 9.5 - 9.45
Creatinine: 1.1 - 0.85 (to admit this is better)
HbsAG-quantitative : 2308- 2440 iu/ml (6% increase),
AntiHbs: negative- negative ,HbeAG: negative-negative,Anti-Hbe:positive -positive
HBV-DNA: 162.678 copies/ml
ALT:30 - 35
HDL:37 - 35,
HBVDNA: 162.518 - (not ready yet)
I will restart using D3 supplement, but this time I will try to take it together with vitamin K2 as my order from biotech has been delivered to me.I had been living kidney discomfort after taking monthly dose of 300.000 iu, will try to take more gradual dose.
By the way i had guessed steep decline in vitamin d level because my general immunity and energy level has become worse.
update of tests after 6days on 50.000-60.000iu of d3 daily (of this amount 10.000iu was from biotech d3 plus, so there was 1600mcg of vit k2 and other cofactors), finally i got a good amount of 25ohd3 as i wanted:
Question; How do you calculate how much Vitamin K and magnesium to take in proportion to VitD3 dose?
there was a youtube link with an interview to dr mercola and a research but i dont remember the doses they supposed
there is no toxicity from vit k2 (mk7) so only cost is the real problem.if we look at d3 plus they use 800mcg of k2 for 5000iu of d3
"At last Edible GcMAF exists. It arrives in a bottle and is a 5ml teaspoon taken orally. It is delivered through the intestines straight to the liver, from where it reaches the rest of the body. Edible GcMAF’s price is €600 plus €60 shipping. In the laboratory, it is more effective than standard GcMAF, and it is mainly aimed at cancer."
just the stabilized vitamin d which already contains gcmaf bound to oleic acid and vit d to attach to vdr directly, now we just have to see if only supplementing with vit d3 this can be achived or if this is the combo of d3+stabilized vit d+tenofovir
i actually started both stabilized vit d and high dose vit d3 the same day so i cannot tell what was doing the big jump.to note that i started "stab vit d" on the 27th of sept and high dose d3 60.000iu at start the 3rd of october so just 3days on d3 60.000iu per day before the hbsag test
with your result we have got very strong correlation between vit d3 and hbsag,
that both are inversely proportional to each other.
but question is whether it is possible without tenofovir,
is there any buddy have such experience then pls share.
As analytical scientist i think that cholecalicferol (Vitamin D3) is very much sensitive to light and heat hence stabilized vitamin d3 is more potent than plain Vitamin D3, as it is protected from light and heat during the tablet formulation. hence with less quantity of stabilized vitamin D3 we can reach more fastly to beyond 100ng/mL level.
the difference is "stab vit d" bounds directly to vdr receptor with no possibility that the virus can interfere and reaching much higher activation of vdr.both nagalase or the virus trying to lower 25ohd3 levels will have no effect
while plain vitamind25oh will get in circulation and will have to bound to our own gcmaf not blocked by nagalase and oleic acid to attach the vdr, of course if we rise d325oh serum levels to very high like 150-165ng/ml more and more vitd can reach our own gcmaf and attach the vdr.in this pathway also the level of nagalase and vdr receptor genotype will impact the final effect
Do you have an explanation?
I can only think of the following....
The number of infected cells could not obviously have changed so quickly, so this sharp decrease in hbsag is probably attributed to the inhibition of Surface protein synthesis in the cells. This synthesis occurs outside of the nucleus from RNA. Probably this abundant quantity of vit d has blocked VDR of nucleus and RNA can not get out. It means that the other viral proteins are not synthesized either so the replication is blocked by jus Vit D and there is no need in tdf?
What is the difference between GoLeic and stabilized vit D?
stabilized vitamin d bounds directly to the vdr receptor, while goleic still needs vitamin d to attach vdr, it is probably designed for severely compromised immune system where you can t use full potency
if you start stab vit d follow instructions on the website, i started low dose 0.1ml and since no sides or effect i went for full dose.just felt some dizziness first weeks for about 1-2hrs
do you have any clues about this sharp decline of hbsag in few days?the only things changed are:
started stab vit d, a compound that binds directly vdr receptor on the 27th of sept and 60.000iu of d3 daily the 4th of october, the 9th of october vitd25oh was 128ng/ml
20 apr 2012 7309iu/ml vitd25oh 72ng/ml (march 2012 test)
21 jun 2012 5210iu/ml vitd25oh 58ng/ml (july 2012 test)
16 nov 2012 3687iu/ml
10 jan 2013 4207iu/ml
28 feb 2013 3644iu/ml vitd25oh 67ng/ml
27 mar 2013 4163iu/ml
22 may2013 3201iu/ml
14 june2013 3360iu/ml vitd25oh 87ng/ml
10 july 2013 3800iu/ml vitd25oh 72ng/ml
02 aug 2013 vitd25oh 87ng/ml
30 aug 2013 2916iu/ml vitd25oh 103ng/ml
27 sep 2013 3822iu/ml vitd25oh 71ng/ml
07 oct 2013 1957iu/ml
09 oct 2013 vitd25oh 128ng/ml
Stable alt means immune system does not kill the infected cells...
In this case clearance will be slow by natural hepatocytes turnover if the replication is blocked completely, Lets hope that the dynamic will hold and HbsAg goes under so that immune system could start working.
(Statusz: HBeAG negative, genotype A, PCR DNA 200-300 IU/ml, 52th pegasys injection, inf monotherapy, I apply many food supplements)
So, unfortunatelly we should apply high dose vitamine D continuously. It seems that HBsAG drop down is only local in my case. But to gain some insight into the real correlation I intend to start stabilized vit D and improve D3 intake.
Since my HbsAG much higher than yours, the correlation can be prooved with a little bit more certainty :)
That is the same as I have noticed hbsag declines after 25-oh sharp increase, but aftewards it rebounces back to where it was. Probably vit d has some effect in the beginning but afterwards all returns back into old balance.
Lets see what Stef result will show.