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Normal vit D levels are associated with hbsag seroclearance.
Normal vitamin D levels are associated with spontaneous hepatitis B surface antigen seroclearance.
Mahamid M, Nseir W, Abu Elhija O, Shteingart S, Mahamid A, Smamra M, Koslowsky B.
Source
Mahmud Mahamid, Shimon Shteingart, Mosab Smamra, Benjamin Koslowsky, Digestive Disease Institute, Shaare Zedek Medical Center, Jerusalem 93722, Israel.
Abstract
AIM:
To investigate a possible association between serum vitamin D levels and spontaneous hepatitis B surface antigen (HBsAg) seroclearance.
METHODS:
Fifty-three patients diagnosed with chronic inactive hepatitis B and spontaneous HBsAg seroclearance were followed up in two Israeli liver units between 2007 and 2012. This retrospective study reviewed medical charts of all the patients, extracting demographic, serological and vitamin D rates in the serum, as well as medical conditions and current medical therapy. Spontaneous HBsAg seroclearance was defined as the loss of serum HBsAg indefinitely. Vitamin D levels were compared to all patients who underwent spontaneous HBsAg seroclearance.
RESULTS:
Out of the 53 patients who underwent hepatitis B antigen seroclearance, 44 patients (83%) had normal levels of 25-hydroxyvitamin vitamin D compared to 9 patients (17%) who had below normal levels. Multivariate analysis showed that age (> 35 years) OR = 1.7 (95%CI: 1.25-2.8, P = 0.05), serum vitamin D levels (> 20 ng/mL) OR = 2.6 (95%CI: 2.4-3.2, P = 0.02), hepatitis B e antigen negativity OR = 2.1 (95%CI: 2.2-3.1, P = 0.02), low viral load (hepatitis B virus DNA  8 years) OR = 1.6 (95%CI: 1.15-2.6, P = 0.04) were also associated with spontaneous HBsAg seroclearance.
CONCLUSION:
We found a strong correlation between normal vitamin D levels and spontaneous HBsAg seroclearance.
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With these numbers you need to go on interferon. And maybe in 6 months you will be a new man.
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I will try taking  25000 units daily. And increase vitamin k2.

I am not able to clime past 50ng on 10-15000 iu of vitamin d3.
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The DNA went below 20 iu from 70 a month ago and ALT went up from 50 to 70.
Optimistically it can be interpreted as follows:

When VL is getting down reinfection decreases also
ALT up means the immune system kills more infected cells.  All this decreases the quantity of infected cells, and therefore decrease  hbsag production.

The problem is as the number of infected cells goes down the immune response goes down too, so it should come to another balance point but not clear completely.
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http://www.healio.com/hepatology/chronic-hepatitis/news/online/%7B8f54ef2a-1341-40e6-84d1-de714b2effff%7D/antiretroviral-therapy-decreases-25-oh-vitamin-d-levels-in-hivhbv-coinfected-patients

Antiretroviral therapy decreases 25-OH vitamin D levels in HIV/HBV coinfected patients

this is on hiv coinfected too so it may not have the same results on hbv but anyway it is best to supplement d3 for us hbvers and use high dose d3 if the blood levels stay low both off therapy or on nucs therapy
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Stef, is your sisters viral load in thousands or in hundreds/tens? I could see decimals, got confused.
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thousands
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http://mpkb.org/home/pathogenesis/vitamind/metabolism

wonderful article which explains why vid25oh is low on chronic diseases and 1,25d is high and how this correlates with chronicity of diseases, suppression of vdr and suppression of immune system and antimicrobial peptides

this applies to hbv too, a normal level of vit25oh reflects a normal vdr and a normal immune response or production of antimicrobial peptides and so a higher chance of hbsag clearance.
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a normal level of 1,25d3 and 25d3 might reflect a normal vdr activity thus a normal immune activity, almost all chronic diseases have high 1,25d3 (the body try to activate more vdr receptors by making more 1,25d because viruses/bacteria/cancers have blocked vdr by nagalase or other means)

when patients dye, especially aids but other diseases too, d25oh and 1.25d become undetactable, vdr is complitely blocked and nagalase very high...this is part of the ways to suppress/evade immune system
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also this is another point that antivirals are bad for us. They suppress the immune system..

Demand new drugs people!
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no they are not bad, they are good because they rescue cd4 and especially cd8 immune response to hbv, of course they must be followed by immune therapies like pegintf to also rescue nk cells response to hbv and finally clear hbv
without both of these interventions there is no immune system activity to clear hbv, also replicor without pegintf showed no sustained hbv clearance
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This article insists that low vit D is a result but not a cause of chronic deseases and they say that supplementing vit d is not proven to be beneficial it is  even vise versa...
:::::
Supplemental vitamin D is being touted as having a wide range of benefits in different diseases. A puzzling picture that emerges from the totality of the diseases that they are claimed to affect beneficially, is the belief that supplemental vitamin D will both reduce infections and suppress the immune system at the same time. While it is clear that there exist substances that can be “immunomodulating”, implicating that it can increase production/release of both immunosuppressive and immune activating substances, the important question is what the overall effect is. It is hard to envision that a substance can have strong anti-infectious properties while at the same time having a strong immune suppressive effect.

Supplemental vitamin D show no consistent effects on infection
In studies on acute respiratory tract infection3, tuberculosis4 and overall infections5, the effects of vitamin D have been mixed (and largely unsuccessful) in terms of reducing infectious burden.

A complete evaluation of the above mentioned studies, and the differences between them that can help explain the different results, is not suited for this article. However, on a general basis, one of the reasons for differing effects may be that vitamin D works differently in relatively healthy people as compared to sick people. Thus, vitamin D supplementation may give a marginal benefit in preventing infections in healthy people (see section below), but not in sick people. As of today (Dec 2012) we are not aware of any studies that have shown an actual reduction in infections in sick people (for instance tuberculosis or COPD) by vitamin D supplementation, as measured by culture or genetical detection methods. Furthermore, a general trend seems to be that apparent beneficial effects on infection in healthy people are not seen in individuals who have 25-hydroxyvitamin D levels within the normal range678, adding, as a side point, further weight to the mega dose vitamin D supplementation craze being without merit.

It is however not certain, in spite of some reported benefits in a few studies, that any level of supplementation is beneficial in terms of reducing infection. The studies are still too few to draw firm conclusions, and publication bias, as in any field science, may skew the overall results. Another factor which makes the reported benefits doubtful is that not all studies have reported an actual reduction in infection, but merely symptom based outcomes. Symptom based outcomes are relevant, but in light of the symptom reducing effects therapies that are immune suppressive may have, it is not clear that symptom reduction in the vitamin D supplementation studies are due to an actual reduction in infection. Further, most of the symptoms in upper respiratory tract infections are caused by the body's own immune response, and not the infectious agents9.

In sick people vitamin D supplementation increases infectious burden, and suppresses the immune system:

monocytes – According to a 2011 interventional study in which patients with multiple sclerosis were given high doses of vitamin , peripheral blood mononuclear cells (monocytes) lose “abnormal reactivity” at 40 ng/mL.10
Epstein Barr virus – In a 2010 study of pregnancy-associated breast cancer, higher levels of 25-D were positively correlated with serum antibodies to Epstein Barr Virus, suggesting that EBV is able to better proliferate in patients who take vitamin D.11
toll-like receptors – As discussed elsewhere, the toll-like receptors (TLR) represent an ancient front-line defense system that enables the host organism to sense the presence of microbial components within minutes. As inducers of inflammation, TLRs act as important triggers of distinct entities such as sepsis or autoimmune disease exacerbation.12 For example, found that the TLRs are naturally upregulated in the autoimmune disease, Behcet's disease.13 However, a 2006 study showed that vitamin D3 suppresses the expression of TLR2 and TLR4 protein and mRNA in human monocytes in a time- and dose-dependent fashion.14 Dickie et al. further showed that expression of TLR9 was downregulated in monocytes by vitamin D3 supplementation.15
reduction in levels of inflammation – A 2011 study showed that in colorectal adenoma patients, the vitamin D supplementation group, TNF-alpha decreased 13%, IL-6 32%, IL-1 beta 50%, and IL-8 15% relative to placebo.16
short-term symptom resolution – Further evidence for vitamin D’s activity as an immunosuppressant comes in the range of reports of short-term symptom resolution in autoimmune patients taking vitamin D. Online forums are full of such reports.
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we need high levels of vitamin d anyway for all infections, immune system to work, peginterferon to work, fatty liver and cancer prevention and so on they have no proof it is otherways on human trials while we do have human trials results of thousands.....it even looks like hbsag slowly goes down on those supplementing year after year so we better keep vit d at max normal level

also remember only human trials with results are to consider because there has always been disinformation from drug makers and immune suppressive effect of vit d is one of their old stupid ways, it just does not exsist otherwise you would not cure/prevent cancer and so many diseases by high vit d....
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my sister's
15 06 2010   hbsag   17379iu/ml vitd25oh 11ng/ml
28 09 2011   hbsag   18183iu/ml vitd25oh 66ng/ml  hbvdna 88.864iu/ml
15 02 2012   hbsag   17476iu/ml vitd25oh 69ng/ml  hbvdna 432.220iu/ml
20 04 2012    hbsag  20790iu/ml vitd25oh 68ng/ml  hbvdna 58.180iu/ml
24 01 2013    hbsag  13783iu/ml vitd25oh 76ng/ml  
10 07 2013    hbsag  12906iu/ml vitd25oh 67ng/ml  

i see a decreasing trend, we will now try 100ng/ml of 25ohd3 and see if the trend increases
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this is me but much less relevant because too many treatments, but if all off therapy post hbsag vs vitd25oh it is interesting data anyway

20 apr  2012  7309iu/ml  vitd25oh 72ng/ml (march 2012 test)
21 jun  2012  5210iu/ml  vitd25oh 58ng/ml (july 2012 test)
16 nov  2012  3687iu/ml
10 jan  2013  4207iu/ml
28 feb  2013  3644iu/ml  vitd25oh 67ng/ml
27 mar 2013  4163iu/ml  
22 may2013  3201iu/ml
14 june2013  3360iu/ml  vitd25oh 87ng/ml
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Is your sister on any treatment?
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no, no treatments because her liver is ok

plans in 1 year maximum are to start tdf for peg add on as hbsag reaches less than 10.000iu/ml
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though i in favour of vit d , but whats the trend in data you ae seeing.

one more important observation ur sis has higher hbsag than yours but she has immune control on it without any treatment ? what could be the possible dynamics? doesn't it mean we are exxagerating hbsag's role in hvb?
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she has no immune control at all, her hbvdna is in the thousands and alt in 60-90 plus hbsag over 10.000iu/ml, hbeag negative and probably bcp and precore mutants as almost all hbeag neg....so she also has no liver damage thanks to no immune control and good active stemcells in liver repair

maybe vit d will activate her immune system and bring hbsag down and fibroscan up....we will see by the following years
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I do not see correlation with vit D level in yoir sister's hbsag. When she started taking it hbsag even increased.
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This results shows me that Vitamin D does not affect Hep B DNA or HBSAG. If it works, it should lower DNA or HBSAG within a few month at most.    Tenofovir or PEG can lower these in a month or few month.  

Flameboy also demonstrated GCMAF does affect HBV DNA OR surface antigen.  

No point using good money on things that does not work.  Although, must thank Steff for trying to look for alternatives.  
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