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Normal vit D levels are associated with hbsag seroclearance.

Normal vitamin D levels are associated with spontaneous hepatitis B surface antigen seroclearance.
Mahamid M, Nseir W, Abu Elhija O, Shteingart S, Mahamid A, Smamra M, Koslowsky B.
Source
Mahmud Mahamid, Shimon Shteingart, Mosab Smamra, Benjamin Koslowsky, Digestive Disease Institute, Shaare Zedek Medical Center, Jerusalem 93722, Israel.
Abstract
AIM:
To investigate a possible association between serum vitamin D levels and spontaneous hepatitis B surface antigen (HBsAg) seroclearance.
METHODS:
Fifty-three patients diagnosed with chronic inactive hepatitis B and spontaneous HBsAg seroclearance were followed up in two Israeli liver units between 2007 and 2012. This retrospective study reviewed medical charts of all the patients, extracting demographic, serological and vitamin D rates in the serum, as well as medical conditions and current medical therapy. Spontaneous HBsAg seroclearance was defined as the loss of serum HBsAg indefinitely. Vitamin D levels were compared to all patients who underwent spontaneous HBsAg seroclearance.
RESULTS:
Out of the 53 patients who underwent hepatitis B antigen seroclearance, 44 patients (83%) had normal levels of 25-hydroxyvitamin vitamin D compared to 9 patients (17%) who had below normal levels. Multivariate analysis showed that age (> 35 years) OR = 1.7 (95%CI: 1.25-2.8, P = 0.05), serum vitamin D levels (> 20 ng/mL) OR = 2.6 (95%CI: 2.4-3.2, P = 0.02), hepatitis B e antigen negativity OR = 2.1 (95%CI: 2.2-3.1, P = 0.02), low viral load (hepatitis B virus DNA  8 years) OR = 1.6 (95%CI: 1.15-2.6, P = 0.04) were also associated with spontaneous HBsAg seroclearance.
CONCLUSION:
We found a strong correlation between normal vitamin D levels and spontaneous HBsAg seroclearance.
Best Answer
Avatar universal
that s good i think we hve to try to make it very high like 100ng/ml and see what happens, i guess the response might be very very slow like for my sister when hbsag is high and faster when hbsag is 1000-1500iu/ml

our experience here might build a good evidence if many participate
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Avatar universal
hbv
Changes can be seen here http://www.medhelp.org/posts/Hepatitis-B/Vitamin-D3/show/1700894#post_7778026 i have mentioned my virus load was up to 20,000-40,000 iu/ml prior to taking any medication and vit d3.
on March 2013 I started Vit d3 and been tested twice.
HBV DNA ( Jun-2013 ) = 4,154 iu/ml
HBV DNA ( 05-Oct-2013) = 1024 iu/ml.

My Genotype is A.
I will now check my HBSAG quantitative now and will share u for advice. Thanks stef2011 for the advice.
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Avatar universal
"we are not interested, please do not go off topic

just vitamin d increase and hbsag response in this thread started because a human study found hbsag is cleared in patients with higher vitamin d in serum"

The study says normal levels of Vit D around 30-40, not high.

And I wasn't off-topic, I was just trying to help..after all, we are all sick with the same disease.
The fact that gcmaf producers are publishing a paper saying a tenfold increase in GcMAF with a VDR agonist and you guys are ignoring that information makes no sense to me.
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Avatar universal
redlabs.com has this test and nagalase test available, since it is a genetic test i guess just a blood stain should be enough

your worst scenario would be Bb/ff, this has very slow response but still responds.
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Avatar universal
Thank you.
Unfortunatelly, the complete genotype test is not easily available here.
I don't know my full genotype yet.

I started with 3 drops (stabilised vit d ) sublingually on Tuesday before sleep. The second dose was 4 drops together with a 180mcg pegasys injection on Friday. No sides, except noticable fatigue and mild joint pain. (D3 - 20000 iu/day)
I will continue this 3+4 drops / week technique.
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Avatar universal
Bb/FF
Bb= moderate responder
FF= high responder

also FF is very important more than bb part, what is your complete genotype?

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Avatar universal
Stefan, what is your bsml vitamin D receptor genotype?
(Mine is Bb.)
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