Normal vit D levels are associated with hbsag seroclearance.

[Rome70]

Normal vitamin D levels are associated with spontaneous hepatitis B surface antigen seroclearance.
Mahamid M, Nseir W, Abu Elhija O, Shteingart S, Mahamid A, Smamra M, Koslowsky B.
Source
Mahmud Mahamid, Shimon Shteingart, Mosab Smamra, Benjamin Koslowsky, Digestive Disease Institute, Shaare Zedek Medical Center, Jerusalem 93722, Israel.
Abstract
AIM:
To investigate a possible association between serum vitamin D levels and spontaneous hepatitis B surface antigen (HBsAg) seroclearance.
METHODS:
Fifty-three patients diagnosed with chronic inactive hepatitis B and spontaneous HBsAg seroclearance were followed up in two Israeli liver units between 2007 and 2012. This retrospective study reviewed medical charts of all the patients, extracting demographic, serological and vitamin D rates in the serum, as well as medical conditions and current medical therapy. Spontaneous HBsAg seroclearance was defined as the loss of serum HBsAg indefinitely. Vitamin D levels were compared to all patients who underwent spontaneous HBsAg seroclearance.
RESULTS:
Out of the 53 patients who underwent hepatitis B antigen seroclearance, 44 patients (83%) had normal levels of 25-hydroxyvitamin vitamin D compared to 9 patients (17%) who had below normal levels. Multivariate analysis showed that age (> 35 years) OR = 1.7 (95%CI: 1.25-2.8, P = 0.05), serum vitamin D levels (> 20 ng/mL) OR = 2.6 (95%CI: 2.4-3.2, P = 0.02), hepatitis B e antigen negativity OR = 2.1 (95%CI: 2.2-3.1, P = 0.02), low viral load (hepatitis B virus DNA  8 years) OR = 1.6 (95%CI: 1.15-2.6, P = 0.04) were also associated with spontaneous HBsAg seroclearance.
CONCLUSION:
We found a strong correlation between normal vitamin D levels and spontaneous HBsAg seroclearance.

[stef2011]

no, to me it has no role at all because my sister also lowered hbsag about 50% by vitd25oh around 80ng/ml.........but having hbvdna und by a nuc is necessary to have a weaker virus, to avoid mutations and rescue immune response for the future pegintf add on when hbsag 1000iu/ml is reached

we need many other memebers to replicate these results, we won t have homogeneous results for sure because vdr genotypes, nagalase and other factors are important too but we should see a decline

[Ashi2010]

U are right we are here to find the solution how to lower the Hbsag.
and i think you are on same path with next month result you will be below 1000 iu/mL (I hope) i want to know is there TDF also having any role in lowering the HBsag in your case.

[Bnd11]

Hello Dreft,
Scientific evidence is a difficult thing. In my opinion GCMAF probably has more evidence than Dr. Marshall's notion. I say it based on reading the research  papers about these two different things.

Please look at the following, that is not a positive opinion about Marshall's protocol:
http://rationalwiki.org/wiki/Marshall_Protocol

I don't want to critise you or dr. Marshall's, please don't feel that. My aim with my short message was absolutelly not that.
My hope is that vit D, stabilised vit d, pegylated interferon has a strong synergistic effect on reducing HbsAg level.

Of course, I should note that GCMAF is also an invention which need more scientific evidence :) As a hep b patient I will give a try for this hypothesis similarly to Stef. And in case of positive effect I will be glad if many many hep b patient can use it.

Let us show you another example.
Journal of Hepatology is the most relavant scientific journal for hep b researchers. Independently from this fact, sometimes I feel that some paper in Hepatology are not so relavant since there are so many variations  ( genotypes, HbeAg,NA naive or not, ...). So conducting experiments with 20-40 patients might be not so relevant. In these cases repeating the experiments by different research groups is very important. Along this way all the results together forms reliable scientific evidence.

[stef2011]

we are not interested, please do not go off topic

just vitamin d increase and hbsag response in this thread started because a human study found hbsag is cleared in patients with higher vitamin d in serum

all the blah blah in another new thread please

[dreft]

"i lowered my hbsag more than 50% in 10 days" ...good for you! ...really!
I just wanted to understand  the reason why you lowered it...you took high dose D ang gcmaf before and did not lower HBsAG that much,, it is only after starting stab vit D that it happened?...which seems to contain a VDR agonist in it
Did you know why you lowered it so much?

"Dr. Marshall is not a medical person. He is a chemical researcher who is using software for simulations. So the proof of concept behind his notion is absolutely not reliable, not verified." ...medical person or not, he was invited by Craig Venter (the genius behind the human genome) to write a chapter in his book...that means Craig Venter thinks he is right, at least partially. That Craig Venter is one of the smarters men on this planet, he cannot be wrong about it (sure, there is always a possiblity, but very small). That is the main reason I trust his theory, but you do what you want, it is your own body, of course.


What do you guys think about that idea: taking GcMAF with a VDR agonist, did it sound right with that tenfold increase?...at least stef11 must know more about it, he has direct contact with these scientists...this idea was presented by a "medical person", maybe Bnd11 believes this one

[Bnd11]

Dr. Marshall is not a medical person. He is a chemical researcher who is using software for simulations. So the proof of concept behind his notion is absolutely not reliable, not verified.