I was detected HBsAg positive in the year 2000 when I had a Jaundice attack. In the year 2006, prior to my marriage, I decided to take Hep B seriously and started pegasys interferon therapy as advised by my doc. Following was my profile when I started interferon:
HDV IgM Ab, EIA - Negative
Genotype - D
Polymerase Mutatons - Not Detected
Precore Mutation - Detected
BCP Mutations - Not Detected
HBV DNA at 50000 IU/ml
Doc told me due to my genotype there are less chances of complete cure, still went ahead and prescribed me 48 weeks of peg intereron.
Within 12 weeks HBV DNA was undetectable, however, had to stop interferon due to mild jaundice attack in Nov 2007, i.r 24 weeks later.
Jun 2008, HBV DNA remained undetectable.
Jan 2009, HBV DNA at 25,200.
Dec 2009 HBV DNA at 115 IU/ml.
Why the HBV DNA is fluctuating after the treatment?
Would it be advisable to take peg interferon again? I had very mild side effects of interferon, mainly thyroid problem resulting into some weight loss.
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