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Please help interpret my HBV DNA results
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Please help interpret my HBV DNA results

PCR
HBV viral load:  18,957 IU/ml 110,330 copies/ml

A year ago, my test was 247 IU/ml so it really spiked up. Should I be alarmed?

I'm chronic hep b carrier with hbeag (-) and anti-hbe (+) with normal ALT levels. Thanks.
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Avatar_m_tn
Your viral load is elevated and close to 20,000 iu/ml, but because your ALT is still normal, you will need to monitor your situation closely. A series of viral load and ALT results are more useful. You may also want to have a Fibroscan to determine the state of your liver. Other factors in considering treatment are: age over 40, family history of liver diseases, and any symptoms.

Just my opinion.
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Avatar_m_tn
Your viral load is elevated and close to 20,000 iu/ml, but because your ALT is still normal, you will need to monitor your situation closely. A series of viral load and ALT results are more useful. You may also want to have a Fibroscan to determine the state of your liver. Other factors in considering treatment are: age over 40, family history of liver diseases, and any symptoms.

Just my opinion.
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4900949_tn?1361384160
Thanks. I'm 29 years old. Did liver ultrasound and it's normal. Will go visit a doctor tomorrow to get some advice.

What are the different factors that affect fluctuations in HBV DNA (viral load)?
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Avatar_m_tn
Usually minor fluctiuations are not considered significant, only at least 1 log, 10-fold, increase or decrease is considered significant. There are infrequent viral breakthroughs, especially during treatment, that are not always given an explanation in the scientific literature, especially if they are transient.
In your case, we are watching out for precore and basal core promotor mutations of the HBV that do occur in some HBeAg negative patients that lead to the so called HBeAg negative chronic hepatitis which requires treatment.
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