Hepatitis B Community
REP 9AC combo with immunotherapy an end for Hepatitis B?
About This Community:

This forum is an un-mediated, patient-to-patient forum for questions and support regarding Hepatitis B. Topics in this forum include but are not limited to, Causes, Diagnosis, Family and Relationships, Living With Hepatitis B, Research Updates, Treatment, Success Stories, Support, Symptoms.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

REP 9AC combo with immunotherapy an end for Hepatitis B?

Toxicology results from weekly monotherapy exposure to REP 9AC or REP 9AC’ in many cases > 1 year resulted in no observable drug related effects on liver and kidney function or in lipid or hematological function.  Major reported symptoms were shown to be related to the development of mineral deficiency likely due to the mineral chelation properties of these compounds and were controlled or prevented with proper mineral supplementation during treatment.
All patients have achieved HBV antibody levels seen in healthy patients after vaccination with a total of 12 weeks of combination treatment and many patients have achieved antibody titers > 1000 mIU / ml. In 8 out of 9 patients who have achieved this therapeutic vaccine-like response, they continue to control their viral infection 12 – 24 weeks after all treatment is stopped.
29 Comments Post a Comment
Blank
Avatar_m_tn
I dont understand what else they have to prove.FDA has to grant accelerated approval to this drug and not pushing people on lifetime drugs. At least give this on compassinate basis to people who suffer the most, liver cancer patients, cirrhosis patients who do not have other alternatives. But once again big pharma wins and we can do nothing to change that. What a pity...
Blank
Avatar_f_tn
Interesting and most promising so far..
Well done Replicor
Blank
Avatar_m_tn
is there a poster about this?
i am not confortable with some words used because a little generic.this treatment is wonderful but we need to understand how our immune system control cccdna in the liver cells fter hbsag is negative and hbsab is high, this is important because a relapse at this stage can be connected with an hbsag mutation

so to sum up:
rep9ac in combo with peg and zadaxin:
12weeks combo all develop hbsab, hbsag und and what about hbvdna values?
8 control infection even after all therapies are stopped, does this mean hbvdna und?
Blank
Avatar_m_tn
what i am unsure of is:
hbsg is cleared by blocking the release of the particles and hbsab becomes detactable but what about cccdna in the liver cells?
was that cleared by peg?was that cleared by our immune system when hbsag und?or it is all there in balance with hbsab......

time will tell if hbvdna by high sensibility pcr is less than 10iu/ml after 48weeks i think the infection should be well controlled and definitely over or maybe a biopsy to check cccdna in the patients so we know 100% the infection was cleared
Blank
Avatar_m_tn
in any case this is the fastest drug we have to clear hbsag and a long period with tdf would be able to ensure there are no relapses whatsoever after we clear hbsag and develop hbsab
http://www.replicor.com/debut_anglais2.htm

will this ever get to clinically available for more patients?
Blank
Avatar_f_tn
You often said that HBDNA is nothing so in this case they didn't mention it.
I can get more info from the guys if needed..
Blank
Avatar_f_tn
Replicor website states "Profound increases in anti-HBV antibodies or immune function were observed in all patients with as few as 6-10 weeks of combination treatment."
My understanding is that increase in anti HBV  antibodies or immune function 24 months after treatment is enough to proof that the treatment is working.
Blank
Avatar_f_tn
One more important point to mention, I am not a Replicor agent, so people feel free to direct your questions to the company.

Blank
Avatar_m_tn
this is a repost of the full replicor abstract that was posted a few days ago.  You can find it on medhelp website
Blank
Avatar_m_tn
in this case hbvdna is important to understand if cccdna inside liver cells is still active.
the difference with the other treatments is cccdna is slowly decreased so that hbsag decreeases, with replicor it is different hbsag decreases because secretion is blocked but we dont know about cccdna so remaining hbvdna at very low titers might reflect cccdna is still there

in any case making hbsag und in the blood activates our immune system so even if we have cccdna in the liver cells the immune system should be able to take care of that.

i guess studyforhope is the only one here with enough knowledge to know what happens
Blank
Avatar_m_tn
all this is great!

When can we try it? That is the question everyone should ask Replicor..
Blank
Avatar_m_tn
what is replicor's next plan? any clue? why is it not published in some reputed journal?
Blank
Avatar_m_tn
So you are saying they pose bogus data? I tend to believe their results.

Believe me HBV is curable with what is available today that they wont  release today.
Blank
Avatar_m_tn
i m not saying that its bogus data. i am only suggesting why don't they publish in good journals to get scince community attention and publish it in media to get public, government, investors attention.
Blank
Avatar_m_tn
The whole abstract is posted here on forums as study summary so this is all legit. I think djxpress posted it.
Blank
Avatar_m_tn
stef .. can you tell what is the recommended dosage of zadaxin?
Blank
Avatar_m_tn
http://www.torrinomedica.it/farmaci/schedetecniche/Zadaxin.asp#axzz2Y6uzIuhQ

i m not expert on its use, anyway these italian health pages describe its use as vaccine booster and doses according to kg of weight, if you use chrome translation to english should not be bad

http://www.rxlist.com/zadaxin-drug/indications-dosage.htm

Chronic Hepatitis B

The recommend-ed dose of ZADAXIN (thymalfasin) for chronic hepatitis B when used as a monotherapy or in combination with interferon (at the labeled dose and schedule for interferon) is 1.6 mg (900 µg/m2) administered subcutaneously twice a week for 6 to 12 months. Patients weighing less than 40 kg should receive a ZADAXIN (thymalfasin) dose of 40 µg/kg.
Blank
Avatar_m_tn
People. We need to start an online action on all HBV forums in every country.

Replicor is the cure. their treatment can give us a new life. A real life. We need to atop talking about TDF EtV and all that. This is what people should focus on.

As for FDA dont worry about them. Getting treatment outside the US is no problem.
Blank
Avatar_m_tn
http://www.replicor.com/debut_anglais2.htm

Here is the list of Replicor associated research institutions. Lets start contacting them also.

people if we want to have a chance to live we need to get this medicine. It is available and it works.
Blank
Avatar_m_tn
replicor replicor and replicor , it is the the solution those people are putting in their locker for god sake who can contact them or the people who were in trial ,please contact them and try to find out some thing usrful for us people.we need this at any cost this community has to pay. USA people please wake up u r the hope of world.
Blank
Avatar_m_tn
We need a big pharma to buyout the maker of REP 9AC and get it all out in the open market. At least a trial involving a large scale.

So far a lot of promising new drugs for Hep B and let's hope a cure is on the horizon. Let's all pray for the sake of humanity.
Blank
Avatar_m_tn
The only way I see this going anywhere is to get the media involved.

As for cures yes there are better treatments available and drugs that can be used today.
Blank
Avatar_m_tn
Hi,

  I am following this drug since 2009 and I think we are very close to the end...!!!

I suggest to release a Face book address under name of

      ( STEP FOR HBV CURE),

then we can see the amount of followers for this account and can write to Replicor company and.....etc.

Now we need a volunteer to establish this account and release(unfortunately I am not expert in such job)..

Thanks
Blank
Avatar_m_tn
thats very good idea MHMD.  why not we start a new  our own website ,funding can be come from inside us mebers. then further members can register for free. this will help a lot to put our voice and making people aware. So members who are from software or have knowledge of web hosting should take initiative without having a doubt in mind, we all are with you. at least we shoud try as collective power, instead of individual. we can force those greedy pharma to follow their responsibility towards society.
Blank
Avatar_m_tn
Well lets have one thread opened here on this board. We all sign it. Give links to it on others forums in your country  so they come here and sign it. And lets appeal to these drug companies. I am telling you guys this for a long time.
Blank
Avatar_m_tn
we must try it.
Blank
Avatar_m_tn
I think the fastest way to select some candidates from this forum or any other advocates .. to visit and try to convince some wise open-minded .. kind ..  millionaire .. billionaire.. to help Replicor staff in completing their trials ..
for example:
Mohammad bin Rashid ... Dubai Ruler
Tamim bin Hamad .. Qatar Emir ..
Bill Gates .. Microsoft founder
W. Buffet
Any other wise and helpful human ..
Blank
Avatar_m_tn
Replicor is still working on it. I don't know why they don't move forward to the FDA approval process. Seems current clinic trail is informal. A formal clinic trail monitored by FDA is required to get approval. The data published by Replicor seem so promising, does anybody know what stop them move forward to a FDA process? Money? Safety?
Blank
Avatar_m_tn
let us have a look on hep c progress, they have found an interferon free regiem, a lot is going on and whats new in hep b, entacevir and tenofovir aah. nothing from 6 years, our researchers are sleeping with their profits and grants from nucs companies. may be they will ate dollers in place of food.



http://www.hepmag.com/articles/faldaprevir_deleobuvir_2501_24182.shtml

Faldaprevir and Deleobuvir Cure 95% of Hep C Genotype 1b

Boehringer Ingelheim’s investigational hepatitis C virus (HCV) therapies faldaprevir and deleobuvir (BI 207127), plus ribavirin, cured 95 percent of the participants with genotype 1b of the virus in a Phase IIb study. However, the therapies cured only 17 percent of those study participants who had genotype 1a of hep C. Called the SOUND-C3 study, it was presented at the Asian Pacific Association for the Study of the Liver (APASL) Liver Week in Singapore. Included in the study were 20 genotype 1b participants and 12 genotype 1a participants who took the combination therapy for 16 weeks. Four of those with 1b had cirrhosis of the liver.

Nineteen out of 20 (95 percent) of those with genotype 1b achieved a sustained virologic response (SVR) 12 weeks after completing therapy, which is considered a cure. All of those with cirrhosis were cured. Just two out of 12 (17 percent) of the genotype 1b participants achieved an SVR.

“These promising results indicate the potential of our interferon-free combination treatment to address an unmet medical need, and confirm our decision to focus on [genotype] 1b patients in our pivotal Phase III interferon-free HCVerso trials,” said Klaus Dugi, MD, PhD, senior vice president of medicine at Boehringer Ingelheim.

Three participants (9 percent) in the trial discontinued treatment as a result of adverse effects. Mild rash and nausea were the most common side effects. Among the most-common moderate- or higher-intensity side effects were anemia (16 percent), fatigue (9 percent), vomiting (9 percent) and nausea (9 percent).
Blank
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis B Community Resources
RSS Expert Activity
469720_tn?1388149949
Blank
Abdominal Aortic Aneurysm-treatable... Blank
Oct 04 by Lee Kirksey, MDBlank
242532_tn?1269553979
Blank
The 3 Essentials to Ending Emotiona...
Sep 18 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Control Emotional Eating with this ...
Sep 04 by Roger Gould, M.D.Blank
Top Hepatitis Answerers
Avatar_m_tn
Blank
stef2011
Italy
Avatar_m_tn
Blank
StephenCastlecrag
Australia
9624973_tn?1413019730
Blank
melcul
United Kingdom
568322_tn?1370169040
Blank
CoWriter
Avatar_m_tn
Blank
luckyman316
Avatar_m_tn
Blank
waschool
Ghana