Regarding HBV DNA quantitative test results - Hepatitis B

HEPATITIS B COMMUNITY

Regarding HBV DNA quantitative test results

Post a Question

< Back to Forum

239 Comments Post a Comment

Viewing 201-244 comments:

«1

Most Recent

stef2011

Jan 19, 2012

To: sajid177

limvudine or adifovir

out of guidelines for hbv, they worsen infection and make hbv mutants

the best therapy is sequential treatment with tenofovir 1-3 years and then interferon add on for 96weeks

the only drugs for hbv on guidelines are:
interferon
tenofovir
entecavir

of these 3 entecavir still has a resistance risk and 1.2% of patients develop mutations and resistance on it
tenofovir and interferon zero resistance

lamivudine, telbivudine, adefovir are not firstline and should not be used on hbv anymore

geronimoxx

Jan 23, 2012

To: stef2011

Hi, my result was tested with following results(futher testing on the way);

HBsAg pos
anti-HBsAg neg
HBcore Ig pos
HBe neg
HBe Ig pos

We have been together for 7 years, what are the odds i am infected. Does this mean she has been infected for a long time or is it something recent ?

Thx,

John

geronimoxx

Jan 23, 2012

To: all

Pls disregard last post.

--cross posted--

Thx

John

suchil1973

Jan 23, 2012

To: stef2011

Hi,

I got diagnosed with Hep B in 2003. It was in inactive stage at that time. I took it lite. I got tested it again 2008. It was still in inactive stage. I was happy. I got diabities in 2010. I did my best to keep Alc in control. Now it came down below 5.6 in my last annual test. But I got bad news that Hep B is active report says

QN, REAL TIME PCR

Hep B Virus DNA - 110 H (<20 IU/mL)
Hep B Virus DNA - 640 H (<116 copies/mL)

I take alcohol weekly once (4 Pegs)

Can you explain me my situation and what I need to overcome it?

lotku

Feb 09, 2012

WHat this means my result in Hapatitis B quantitative test is 24IU/ml ??
help me to understand this.

Mars86

Feb 09, 2012

To: stef2011

Hi Stef;

I am male (26 yrs) , I got diagnosed with HBV during blood donation test in 25/12/2011 below is my results:
HBsAg +ve
HBeAg +ve
HBeAb -ve
HB Core total +ve
HB Core IgM -ve
GBT 22 ( normal range is between 0--47)
GOT 23 ( normal range is between 0--37)
HBV DNA Quantative by (TaqMan) > 170000000
Real time Abdominal Ultra-sonographic is Normal.
I don't have any symptoms and feel healthy.
A hepatologist advised with Baraclude .5 mg for 3 months and do the PCR test again , is it OK for time being or Not ?
another Question:
reference to above is there any indication about the time I got infected ?
Thanx in Advance

stef2011

Feb 09, 2012

To: Mars86

HB Core IgM -ve
cronic (chronic) probably since birth or very young

GBT 22 ( normal range is between 0--47)
GOT 23 ( normal range is between 0--37)
HBV DNA Quantative by (TaqMan) > 170000000

immune tollerant, best hbv cronic (chronic) status, no damage

A hepatologist advised with Baraclude .5 mg for 3 months and do the PCR test again , is it OK for time being or Not ?

no you must not be treated because immune tollerant, do change hepatologist both choices of drug and status are wrong

monitor liver damage by fibroscan and ast/alt.when ast/alt startes to rise, firboscan rise to more than 7kpa and hbvdna starts to go down it means immune system is activating, at that time you may go on:

tenofovir (not entecavir), if hbvdna still detactable in 6 months add on entecavir and follow hbsag quant in iu/ml.after 2-3 years on this therapy add on interferon to antivirals and monitor hbsag until negative and hbv is cleared for ever

do not treat while immune tollerant because no drugs work without immune response and you may worsen your condition

Mars86

Feb 10, 2012

To: stef2011

Thaks Stef for your fast response..
Actually I have already started treatment via Baraclude .5 mg , specifically I used it for 12 days , what is the status now ? can I stop it immediately or take it till the 3 months be finished ? ...

thanks

stef2011

Feb 10, 2012

To: Mars86

i d stop it immediately because baraclude makes resistance and in your case non response is almost certain with resistance development after 6 months because hbvdna will not get undetactable by six months

tenofovir use or entecavir+tenofovir could have made sense because at least they cross protect each other from resistance and may have chances but anyway immune tollerant treatment doesn t work 99.9% times and makes only damage or resistance with no salvage therapy possible in the future when you do need it

stef2011

Feb 10, 2012

To: Mars86

look also for a very expert liver specialist, the one who prescribed baraclude looks like dangerous and out of guidelines.he may not know hbv life cycle at all, hbv is not a "just take a pill disease", wrong choices like yours canmake much more damage than hbv itself and also keep in mind that most hbvers have no damage and no need of therapies

Mars86

Feb 10, 2012

To: stef2011

Thanks Stef for your efforts :)

stef2011

Feb 10, 2012

To: Mars86

http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2011.06940.x/full

all phases explained here

Mars86

Feb 11, 2012

To: stef2011

Thanks Stef;

but is there any side effects from stopping Baraclude now and after using it for 17 days ? if yes how can I avoid it ?
what about the monitoring interval ? is it 1 year or less ?
would you recommend me a liver expert doctor in Egypt ?

thanks for your time and efforts :)

stef2011

Feb 11, 2012

To: Mars86

in 17days entecavir has not even reached steady blood levels, you can stop it safely, if you like you can check both hbvdna and ast/alt before stopping and if there is little difference you should have no problems
if you find ast/alt abnormal and hbvdna much lower then you d better keep entecavir and add tenofovir to it

sorry i dont know liver experts in egypt

Mars86

Feb 11, 2012

To: stef2011

thank U ;

I'll do the tests and update you accordingly :)

April63

Feb 11, 2012

To: stef2011

I agree with Stefan, except I think the liver condition should be known by now. Relying only on transaminases test could be misleading, don't you think? Or even with minimum damage it would still be immune tolerant phase?

April63

Feb 11, 2012

To: April63

This is when it's becoming little fuzzy for me. When does the immune tolerant phase ends? What if with normal AST and ALT, with high viral load there is some liver damage? Is it still immune tolerant phase?

stef2011

Feb 11, 2012

To: April63

Is it still immune tolerant phase?

ast/alt normal or near normal, bad diet and life style can elevate alt too and make liver damage too

hbsag quant, very high much more than 20.000iu/ml

hbvdna very very high in the millions

liver damage by fibroscan, less than 7kpa, normal liver less than 6kpa

if hbvdn is in the millions and hbsag very high no drug wroks because infected cells are not cleared by making alt elevated, it is much better to wait until alt are levated and liver is damaged, any fibroscan value less than 10kpa can be regressed fast by diet changes, vit d3 and heptech

OrientS

Feb 11, 2012

To: stef2011

i have little fat on liver .. does this increase kpa amount (fibrosis)?

OrientS

Feb 11, 2012

i have little fat on liver .. does this increase kpa amount (fibrosis)?

stef2011

Feb 11, 2012

To: OrientS

yes it does increase fibroscan result as much as the liver fat content

for example my fibroscan was 9.3 and not decreasing in 2010 and after anti fatty liver diet/supplements it went down to 6.3, it was all fat content

fatty liver makes the same damage as hbv leading to cirrhosis and liver cancer as the damage increases, it also helps hbv to avoid immune system so you d better follow anti fatty live regimen, others had benefit in a couple of months from it

http://www.medhelp.org/posts/Hepatitis-B/update-on-my-fatty-liver/show/1500346

i believe natural vit d3, natural vit E, fish oild with minimum EPA 1800mg – DHA 900mg x day and bitter melon+bluberries+black rice made the most

sangeeta23

Feb 12, 2012

To: stef2011

my reports r
hbsag elisa 160(positive)
hbv dna 132iu/ml
hbeag elisa 0.41
liver ultra scan reports al normal..lft is also normal..n i feel absolutely healthy..
i wanted to know if there r any chances of me being hbsag negative again..n if so den wats the treatment fr it??

sima5678

Feb 12, 2012

i had taken hepatitis b antidote in 12 years ago,,,but since 2007 i have physical relationship(non-protected sex) with my partner,,he has hepa b(chronic),,,is there any chance of infections????currently i have mild pain in my right abdominal area

Mars86

Feb 12, 2012

To: Mars86

Hi Stef;

kindly find below results after using Baraclude for 19 days in immune tolerance phase :

ALT 32 out of 50
AST 24 out of 37
HBV DNA by Real Time PCR(Quantitative) 839750 Ui/ml ... since 19 days it was > 170000000
Waiting your usual Advise :)

stef2011

Feb 12, 2012

To: sangeeta23

never make elisa tests again, elisa is a useless test for cronic (chronic) carriers and too old to be still used today on hbv

to clear hbv you need a liver specialist and proper tests, abbott machines are the best to make antigen and antibodies hbv quantification

there is only one cure sequential treatment by tenofovir and then interferon add on, hbsg quantity in iu/ml is essential

do not make ultrasound to know liver damage, US cant detect liver damage but just liver cancer

hbv has no symptoms till death, only a fibroscan can tell if your liver is damaged or not

stef2011

Feb 12, 2012

To: Mars86

you are responding and can keep using it but you need to be absolutely sure your doctor will add tenofovir if hbvdna is still elevated at 6 months of etv therapy.if you can chosse whatever drug i d make etv+tdf so hbvdna will get undetactable very fast and after 6-8 months of combo you may use tdf only

be also sure to have resistance test for lamivudine and entecavir resistance before hbvdna is undetactable, these resistance mutations can be easily present even if you never had these drugs and can make etv resistance

for example i have a secondary mutation to lam and adv even if i never used these drugs and entecavir was not potent enough on me and so i comboed etv+tdf.

Mars86

Feb 12, 2012

To: stef2011

Thanks for ur advice :)

But what after 8 months or 1 year of Combo ? may it be cleared at all ? I mean HBsAg could be negatve ?

;)

stef2011

Feb 12, 2012

To: Mars86

no entecavir has almost no effect on hbsag, just like all other antivirals

but if you can make interferon add on after a long period of about 1-2 years with hbvdna undetectable youu have very high chances to clear hbsag

for interferon to work hbsag must be less than 20000iu/ml, hbvdna undetectable and alt possibly abnormal

Mars86

Feb 13, 2012

To: stef2011

Thanks Stef , Actually I can't understand how could entecavier supress HBV DNA and couldn't stop HBsAg ? I mean HBsAg is a result from the presence of HBV DNA ? right ?

So I guess if HBV DNA is disappeared then HBsAg could disappear as well , Please correct me if wrong.

Thanks a lot for your valuable advice :)

stef2011

Feb 13, 2012

To: Mars86

no hbvdna is just a measure of how drugs work, hbv life cycle is based on cccdna which produces hbsg and all antigenes and virions, cccdna is the virus template inside liver cells integrated in our own human dna and is not affected by antivirals but only by interferon.butinterferon works only when hbvdn is fully und and some immune system response is rescued this is why a combo tdf+interferon in sequence is needed

check older posts hbvdna has nothing to do with infection, infected cells and hbv life cycle

Mars86

Feb 13, 2012

To: stef2011

Ok Thanks

stef2011

Feb 13, 2012

To: Mars86

anyway you are responding good to etv just make sure hbvdna is less than 50iu/ml or possibly undetactable by 6 months of etv use, then just check if doctors can add on interferon in 1-2 years etv monotherapy

of course we have to be sure you have no pilerase mutants and no lam/etv mutants

Mars86

Mar 13, 2012

To: stef2011

hi Stef;

I hope you're fine , I hope that you remember me , I have just taken etv for 40 days but I feel a mild pain in my right side , is it normal to feel like that ?

Thanks

stef2011

Mar 13, 2012

To: Mars86

is it frontal area behind the liver?if it is so it is normal, it will go away as hbvdna gets und and alt less than 30

Mars86

Mar 13, 2012

To: stef2011

thanks Stef , Yes it is this area .. is this meaning that there is a progress in the treatment ?

Thanks in advance

sivaranjaniadi

Mar 20, 2012

To: stef

my hus
Hbs Ag is more than 200,
is it cureable, and thyroid
plz any help to me.
thanks in advance

stef2011

Apr 05, 2012

To: wazpo

hbvdna has no range and no meaning as a stand alone test, you need to know hbsag,ast/alt and fibroscan to have an idea of your staus

hbvdna is not hbv virus, is not hbv replication and is not hbv life cycle, even if undetactable it means nothing to hbv infection and hbv replication goes on even if hbvdna is undetactable

Qadeershaikh

May 03, 2012

To: stef2011

Hello,

I am HBsag positive by Cobas e411 reactive values 8180 and by ELISA 225.

HBeag negative ultrasound normal and ALT SPGT all normal doctor wrote me that u r healthy career and there is no treatment it would be eradicated automatically.

But I couldn't move to join new job due this problem plz help and suggets me any treatment to make HBsAG negative.

stef2011

May 03, 2012

To: Qadeershaikh

nothing availabl ein pakistan now but you can try email to replicor they have trials in india i think

pobitra

May 04, 2012

To: stef2011

My hep B test result as follow as on 22.04.2012,
HBsAg-Positive, HBeAg-Negative(Sample OD:0.064, CUT OFF VALUE:0.105), SPGT(ALT)-57 U/L, HBV DNA-239000 COPIES/ML or 47800 IU/ml
Doctor give me Entecavir 0.5 mg daily and after six month re-test. Is it right Treatment? I am in Bangladeshi Guy. Pls ans to me .

stef2011

May 04, 2012

To: pobitra

useless on hbv and not indicated at your age unless you have liver damage

consider that many doctors are corruped by drugs companies to sell drugs to all, antivirals do not cure hbv so they should be prescribed only in case of liver damage, old age, liver cancer high risk

entecavir is also expensive and not the most potent antiviral on hbv, i bet your doctor did not checked liver your liver damage.....if you have no liver damage by fibroscan i d wait for hbv cures which are close to market

lvgg

May 04, 2012

To: stef2011

Hello, i'm 40 years old HB carrier (since age of 15). The most recent test results:
AFP 1.9
HBVDNA Copies: 5,739, 923 Copy/ml
HBVDNA IU/ML: 986, 241 IU/ML

Should I start taking Baraclude?
Thank you in advance for your advise.

stef2011

May 04, 2012

To: lvgg

as posted already hbvdna is useless to determine use of antivirals, antivirals are good only to limit/block liver damage but if there is no liver damage they are useless.check liver damage first

the only drug with hbv clearance is sequential treatment with tenofovir and intf add on but hbv cures are close so if you have no liver damage you better wait for real hbv cures

pobitra

May 05, 2012

To: stef2011

My date of birth is 30.11.1981. 31 years old.

pobitra

May 05, 2012

To: stef2011

In Bangladesh HBV Cures medicine available or not? In this connection I have no symptom of liver deases. Two week ago before start vaccination i knew that HBsAg Positive. Then i go to the doctor & test as mentioned. Please suggest me what can i do? My date of birth is 30.11.1981. 31 years old.

sekhar1459

May 07, 2012

To: sekhar

.Hi,

I got diagnosed with Hep B in 2010. It was in inactive stage at that time. I took it lite.(Anti HBE1.3) I got tested it again 2012. It was still in inactive stage.But (Anti Hbe .3.20)

Can you explain me - diffence beetween about Antihbe - my situation and what I need to overcome it?

Please advice me - further secure steps.
.

vet345

May 25, 2012

To: vet

Hello! Help me please!
HBV-DNA (pcr real-time) 2580.0 Ul / ml.
its good or bad?

Viewing 201-244 comments:

«1

Most Recent

Related Discussions

hbsag quantity (34 replies):
today i received my hbsag quantity which is 250iu/ml, ...[more]
Should I stop Hepsera? (26 replies):
I been taken Hepsera 10mg daily for 6 years now and the ...[more]
What now? (29 replies):
Hi Everyone, First off I would like to thank everybody ...[more]
Baraclude vs. Viread (209 replies):
Hi All, I am an male in my mid-20's of southeast Asia...[more]
Need advice (7 replies):
I found out I have HBV in Malasyia (randam blood test) m...[more]
HbsDNA test (13 replies):
I check blood testas follow 1996,HbsAg &HbeAg in positv...[more]
Hepatitis B -hbv DNA test (2 replies):
Hi! My husband dicovered about two years ago (October 5,...[more]
HBSAG (31 replies):
I have test HBSAG+ recently and HBEAG Negaitive and HBV ...[more]
When can I stop Baraclude treatment? (130 replies):
I am female, 28 y.o. I have known being the carrier for ...[more]
To treat or continue monitoring (7 replies):
Dear All, thanks for this forum and hope everyone is ...[more]

« Previous Next »

Back to Forum