Relapse 2 years after interferon treatment... What now?

[PinoyHBVDNA]

Hello everyone

I have known since college (around a decade ago) that i was a chronic hepatitis B carrier, all of my siblings also have it because we our mother has it. I went to the doctor 2 years ago i had a HBVDNA test and had 32xxx UI/ ml before my interferon treatment. After 6 months of interferon treatment we were able to bring it down to <6 IU/ ml and was technically "undetectable" . After the treatment i lived a healthy life, i got into sports, no smoking, minimal drinking, etc.

Now i came back after 2 years, i also have a new Girlfriend now and i intend to tell her this but i simply wanted to have myself tested again... I WAS SHOCKED with the results
______________________________
HBVDNA COUNT
49271 IU/ml
286757 copies/ml

SGPT/ ALT 22.06

white blood cells 9.44
red blood cells 5.16
hemoglobin 157
hematocrit 0.453
mean corpuscular volume 87.8
Mean corpuscular HB 30.40
mean corpuscular hb conc 34.7%
rbc distribution width 12.2%
platelet adequate

anti HBE 0.020
HBSAG2 quantification 7100/ IU/ ml
HBEAG 0.374
anti hbs 0.00 mIU/ ml

__________________________

What now? should i undergo treatment again? It's so expensive! Also... How will i tell this to my GF? We havent had sex yet esp knowing this i wont do it with her... Till when? She was born 1983 and i dont know if she had been vaccinated.

My world crumbled... I dont know what to do... I dont want to blame God but it's too painful... I dont want to commit suicide but i feel so hopeless...

Thank you

[stef2011]

hbsag 7100iu/ml gives very little hope to the fact that interferon might work and monotherapy can be both useless or dangerous since hbsag mutants have been reported during interferon monotherapy so this is what i suggest:

prepare yourself by making:
vitamin d serum level 50-80ng/ml
chol tot <150
ldl50
simvastatin 40-80mg and vitd3 supplements

after the first goal is achived:
4 weeks pretreatment with alinia 2-2.5g a day, after 4 weeks check hbsag and wait until it stops decreasing...when it stops start interferon+alinia+simvastatin treatment

simvastatin and vitamin d3 must be kept all the time unless vitamin d gets more than 100ng/ml or calcium rise above normal range or creatinine rise above normal range

at start you need close checks of liver and kidneys function, first month every 2 weeks, if no abnormal changes after first month just check every month or bimonthly

the goal of therapy is to decrease hbsag so hbsag quant is the main test to see if this is working, if no hbsag decrease by 24 weeks stop all because it is not working

hbvdna can be checked but it is useless, if too expensive you can skip this and just check hbsag.an increase of alt with hbsag decreasing means your immune system is clearing virus.if there is hbsag increase and alt rise it means the virus is infecting more cells

[stef2011]

if you used interferon for 6months only this is totally useless, hbvdna has no meaning for interferon treatment only hbsag quantity says if it is working or not and if it is lowering interferon must be continued until hbsag is negative, this can be 2 years or more...of course if severe side effects can be tollerable otherwise it is better to stop it immediately

interferon monotherapy has also very little meaning although most doctors are so blind to just follow giudelines which are absolutely useless, i mean "hbv treatment must be PERSONALIZED according to single patient response" although most doctors are so ignorant to just follow guidelines so they are covered despite not knowing what they are exactly doing

i like so much what the researcher told me in pisa, if you just go to a hospital it is just like going to a fast food (no personalization), if you come here is just like having one great chef to cook for you only

[lxstr]

If you ALT is normal, there is really nothing for you to worry about for yourself. You are in the inactive chronic hep b state.

But you must find a way to tell your girlfriend ASAP. When I found about my chronic Hep B condition about a decade ago, I told me GF immediately and she got tested immediately. Luckily her blood test results came back with strong HBV antibody, probably gained from prior infection and successfully fighting it off.

[LilHope2010]

keep following Myrcludex-b and REP 9AC for clinical trials...these are the only drugs known to cure Hepatitis b

[chanthou]

If I were you I don't care much about viral load as long as ALT is good and liver uktrasiund and fibroscan are good too. Just monitor the evolution every six months. You don't have drug resistance. Buy time until better drugs coming out

[chanthou]

If I were you I don't care much about viral load as long as ALT is good and liver uktrasiund and fibroscan are good too. Just monitor the evolution every six months. You don't have drug resistance. Buy time until better drugs coming out

[PinoyHBVDNA]

someone pls give me advice... it's so painful...