antivirals may take long to make hbvdna undetectable especially on hbeag pos but dont worry too much about it tenofovir doesn t have resistance even if hbvdna stays detectable for years, is yours 214iu/ml?
the good of some detectable hbvdna is that immune system is not totally suppressed by the antiviral and the hbsag decline is easier, also alt is slightly elevated and that is good too
i d stay with this until hbeag becomes neg and hbsag less than 1000iu/ml then if it ever stops consider peg add on while if it doesn t stop it means hbsag will be cleared by tdf in few years
Thanks a lot Stef for your views and suggestion which are, as always, very very helpful.
Yes the HBV DNA is 214 IU/ML.
For the time being his doctor suggests to continue with TDF only like you suggest untill HBeAG becomes negative and HBsAG becomes low enough before adding on peg....but as your views we will see whether HBsAG will continue declining with TDF only.....
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