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Result of treatment using TDF after 9 months
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Result of treatment using TDF after 9 months

Dear all,
Want to share with you result of treatment using TDF after 9 months (my son).

Baseline (before taking Tdf):
SGOT 47 (range for normal: 5 - 34)
SGPT 102 (range for normal: 4-36)
HBV DNA 2.43 X 10^8
HBSag Quantitative: 43,205.18 IU/ML

Result after 3 months:
SGOT 89
SGPT 244
HBV DNA 3.19 X 10^5
HBSag Quantitative: 11,570.50 IU/ML
HBeAG  reactive
Anti HBe  non reactive

Result after 4 months
SGOT 60
SGPT 127
HBsAG Quantitative: 6,029.41 IU/ML

Result after 6 months
SGOT 52
SGPT 90
HBsAG Quantitative: 3,482 IU/ML
HBV DNA 5.7 X 10^3
HBeAG reactive

Result after 9 months
SGOT 36
SGPT 69
HBsAG Quantitative:1,461 IU/ML
HBV DNA  2.14 X 10^2
HBeAG - reactive

Fibroscan
Dec 2012 : 6.8 kpa
Dec 2013: 5.5 kpa

I am happy that HBsAG continues declining but why is HBV DNA, though the trend is declining, still detected? Can anyone give view on this still detected HBV DNA?

Stef, you suggest IP 10 test to see immune response..unfortunately its not available in my country.

Thank you very much for your view.
Afif


6 Comments Post a Comment
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Avatar_m_tn
very very good. Your son is lucky. He will cure the treatment I am sure.
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Avatar_m_tn
antivirals may take long to make hbvdna undetectable especially on hbeag pos but dont worry too much about it tenofovir doesn t have resistance even if hbvdna stays detectable for years, is yours 214iu/ml?

the good of some detectable hbvdna is that immune system is not totally suppressed by the antiviral and the hbsag decline is easier, also alt is slightly elevated and that is good too

i d stay with this until hbeag becomes neg and hbsag less than 1000iu/ml then if it ever stops consider peg add on while if it doesn t stop it means hbsag will be cleared by tdf in few years

dont worry about ip10 as long as hbsag declines
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Avatar_m_tn
Very good decline in HBsAG. BTW, which country are you treating in?

Thanks.
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Avatar_m_tn
Thanks so much for the encouragement!
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Avatar_m_tn
Thanks.
We live in Indonesia......
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Avatar_m_tn
Thanks a lot Stef for  your views and suggestion which are, as always, very very helpful.

Yes the HBV DNA is 214 IU/ML.
For the time being his doctor suggests  to continue with TDF only like you suggest untill HBeAG becomes negative and HBsAG becomes low enough before adding on peg....but as your views we will see whether HBsAG will continue declining with TDF only.....

Thanks again for the inputs.
Afif
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