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Results after 24 week pegays
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Results after 24 week pegays

hbsag +  
anti hbs neg
hbeag neg
anti hbe +
alt and ast normal since 2005
hbv dna less than 116 copies / ml ( undetectable ) 18 months ago

HBsAg quantitaive from 19 IU/ml to 13.4 IU/ml then 16 IU/ml and then 20.23 IU over last 18 months

Started with
-PEG interferon 180 mcg once weekly  
-Vit D

after 5 inj and ALT 103 which had always been previously normal

After 11 inj ALT 70 and HBsAg 18 IU/ml

After 23 inj peg Alt is 42 and HBsAg is 0.21 IU/ml  quantitative
Tomorrow will have 24th inj

What should i do, continue with pegasys or not
I am tolerating the inj quite well
initially had problems but now well tolerated
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Avatar_m_tn
thanks for sharing and very happy for you you pratically cleared lower limi of detection 0.05iu/ml


What should i do, continue with pegasys or not

are you crazy to ask such a question....?

keep 48weeks of peg until good hbsab is reached, hbsag cleared at 24weeks is very good similar to otan result
31 Comments Post a Comment
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Avatar_m_tn
Thanks to God
I am responding and HBsAg has decreased
Comments from every one will be appreciated
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Avatar_m_tn
thanks for sharing and very happy for you you pratically cleared lower limi of detection 0.05iu/ml


What should i do, continue with pegasys or not

are you crazy to ask such a question....?

keep 48weeks of peg until good hbsab is reached, hbsag cleared at 24weeks is very good similar to otan result
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Avatar_m_tn
Thanks a lot Steff
we owe u a lot
thanks

Ur help and guidance is great
i ll complete 48 week pegasys
U are the bright star giving everyone hope

otherwise most of doctors dont give us any hope
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Avatar_m_tn
thanks for the kind words but it is just reading the most recent studies and applying them...and you are right most liver specialists are almost useless to cure patients
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Avatar_m_tn
Steff if viral load is high say over 10million copies. Then using interferon for 48 weeks should clear it?
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Avatar_m_tn
pegintf has almost no chance to clear hbsag with very high hbvdna, it makes no sense to use it this way....better make hbvdna undetectable by nucs first
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Avatar_m_tn
How long on nucs approximately if viral load is high?
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Avatar_m_tn
as you see from other posts too many vairables, hbvdna can be und in 1month  to 12 months and response to peg will also depend on hbsag quant baseline
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Avatar_m_tn
So generally speaking without being "super specific"  12months nucs 11months peg int = hbsab. is that right?
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Avatar_m_tn
You are on your way man. Very good result.

Looks like I am 4 weeks ahead of you (week 29th this week) but I am on 135mcg and no clue on my HBsAG numbers. HBV DNA Undetectable.







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Avatar_m_tn
hbvdna undetectable very early is a sign of response and if hbsag was low baseline like 1000-1500iu/ml there are chances to clear it

what was the reason to lower pegintf, platlets or neutrophils?getting it back to 180mcg would be best
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Avatar_m_tn
HBsAg quantitaive in IU/ml is a good test
Most doctors treating HBV here are unaware of it
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Avatar_m_tn
Its all about effort and hope
I am amazed how most of the hepatitis docs just say ... there is no hope
u have to live with it
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Avatar_m_tn
Where are you from Ali?

In Turkey, I could not find a place for HBSAG quantitiy test
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Avatar_m_tn
Pakistan
Only one lab doing test here
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Avatar_m_tn
Congratulation Ali! Even after 4 years i didn't find any good dr. in my city. On which dr advice you are following ?
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Avatar_m_tn
No doctor.. doing it all on my own
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Avatar_m_tn
read carefully all tests to monitor during therapy and time for the tests.thyroid function, renal function, liver function tests

platlets are tollerable as low as 25.000-30.000, less discontinue or have a specialist use drugs to boost it

neutrophils are tollerable as low as 0.5-0.7, less discontinue or have a specialist use drugs to boost it

thyroid, tsh,t3,t4 and thyroid auto-antibodies
discontinue if hyperthyroidism happens, very rare
hypothyroidism does not require to stop peg but a specialist is needed and t3 or t4 hormones used according to specilist indication
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Avatar_m_tn
yea i have read everything
Spent hours and hours on PEGasys and HBV
Talked to doctors
Know about all side effects

monotoring my mood
Depression
platelet count
Neutrophil count

renal function

In touch with a doc but decision  is mine against his advice
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Avatar_m_tn

In touch with a doc but decision  is mine starting pegasys against his advice
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Avatar_m_tn
very good choice, hope the doctor will learn the lesson from your example
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Avatar_m_tn
Are you measuring your BMI ? What's before and during therapy ?
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Avatar_m_tn
so doctor's now is useless with hepB carriers?
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Avatar_m_tn
I dont know what doc ll learn from my example

They have their guidelines and they follow those
They often forget guideline just give guidance ... not meant to be followed blindly
U need to make decisions for indivividuals ....
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Avatar_m_tn
Just had my 24th inj
Phase I complete (6 months)
Phase II starts next week (6 months of pegasys)
dividing it in parts will help psychologically
when to repeat HBsAg quantitative
-1 month
- 2 months
- 3 months
?????
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Avatar_m_tn
Could you please provide me brand of pegasys, which you are using ? Or better you send it to me privately. If you provide details of all medicines quantity power then it will help much. Thanks.
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Avatar_m_tn
pegasys weekly 180 ..by roche. thats it
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Avatar_m_tn
Rs 5870 weekly
tell me ur entire situation ... I might be able to help u
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Avatar_m_tn
since hbsag is an inexpensive test, or should be, you may test every month and it should be und by next month.clinically you may test every 3 months

you also better start testing hbsab, if we are lucky it should be detactable by 3 months
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Avatar_m_tn
Means Rs. 23480 monthly dosage. :( expensive enough.
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Avatar_m_tn
I have find a method to submit test to Lahore. Decision will be based on QBSAG quantitative test and Fibroscan. Will do next month inshaAllah.
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