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Results after about 2 months of VitD3 5000iu and heptec
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Results after about 2 months of VitD3 5000iu and heptec

In April my viral load was 1.7 mil copies/ml.

the results now:-
Fibroscan -- 4.6 kpa
HBV DNA --  55,814 copies/ml
HBsAg (Quantitative) --  2906.99 IU/ml (cut off= 0.05 IU/ml)
25OH Vitamin D3 --  40.8 ug/l

Alt -- 54 u/l -----high (normal 0 - 44)
Ast -- 53 u/l ----high (normal 15 - 41)

Genotype, Precore Mutation, Polemerase mutation have to wait about 2 weeks.
My alt, art is always a little bit high. My doctor already wanted to treat me and she said I have about 50% chance now if I make peg interferon treatment. But I told her I wanted to wait for the time being.
I think vitD3 or heptec or both helped me in dropping so much hbv dna.

my alt and art is high like this for about 2-3 years I think.



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1191262_tn?1366766621
Hi what were the intial values? We have no history here unless I missed something:)
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Avatar_m_tn
25OH Vitamin D3 --  40.8 ug/l

please check unit if ug/l or ng/ml.me, my sster and my father could get it higher than 50ng/ml only using more than 5000iu, anyway it may still increase by following months

Fibroscan -- 4.6 kpa
your goal should be keep fibroscan always between 4-5kpa, abnormal over 6kpa

HBV DNA --  55,814 copies/ml
i would not care much about this, of course the lower the better but this doesn tindicate anything about infection

HBsAg (Quantitative) --  2906.99 IU/ml
this is the test to keep an eye on and lower to 1000-1500iu/ml so that we have the highest chances to clear on interferon.if possible i'd use simvastatin and nitazoxanide (alinia) and see what happens to both hbsag and hbvdna and once hbsag is in the range 1500 start interferon
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Avatar_f_tn
enolia:

my last results done in (02-05-2011) are as follows:


Total Protein-------  7.8 gm/dl---- normal-----6.5 - 8.1
Albumin------------- 4.4 gm/ml ----normal----- 3.5 - 4.8
Globulin------------- 3.4 gm/dl-----normal----- 2.5 - 3.5
Direct Bilirubin----0.1  mg/dl-----normal----- 0.1 - 0.5
Total Bilirubin------0.7  mg/dl-----normal----- 0.4 - 2.0
Alk. Phosphatase--- 54 u/l -------normal----- 38 - 126
SGOT/AST-----53 u/l---- high-----15 - 41
SGPT/ALT-----50 u/l-----high-------   0 - 44
Gamma GT----13 u/l-----normal---   7 - 50
AFP 4.2 ng/ml------------ normal--- 0.0 - 9.0
ultrasound----normal
fibroscan----- 4.2 kpa

HbeAg Negative

hbv dan 1,775,100  copies/ml  (Test methodology by COBAS Ampliprep/COBAS TaqMan HBV Test)
Log equivalence 6.25 log
Viral Load (HBV DNA) =  305,000 iu/ml , Log equivalence = 5.48

I have never done hbsag ( quantitative ) and 25ohd3 test before.

stef2011:
I checked again the unit of vit d3 test. It is mentioned "ug/l" not "ng/ml".
Is something wrong?

Do you think I can try nitazoxanide (alinia) or simvastatin...together with vit d3?
my alt & ast is a little bit up almost always....you have any idea why??


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Avatar_m_tn
correct info on vit d here

http://www.vitamindsociety.org/
http://vitamindfoundation.org/

Get Your Vitamin D Levels Tested!
Have your physician administer a calcidiol test (also know as a 25-hyrdoxyvitamin D test). More important than your daily intake of vitamin D are your actual vitamin D blood levels. Optimal vitamin D blood levels are 50 ng/mL (125 nmol/L)‚ according to The Vitamin D Council.
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Avatar_m_tn
http://www.vitamindcouncil.org/about-vitamin-d/vitamin-d-deficiency/am-i-vitamin-d-deficient/

vitamin d homekit if you dont find a lab to test vit d by ng/ml unit or nmol/l unit

http://www.zrtlab.com/vitamindcouncil/
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Avatar_m_tn
mili, micro, nono ...
m,u,n
so => 1000 ng = 1ug;

40.8 ug/l = 40800ng/l = 40.8ng/ml

so, from what I still remember from the school it seams to me that ug/l is similar to ng/ml  (or ? )

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Avatar_m_tn
this are good news :)

Could you please give us the full history from when you start to made the tests, to see how HBV DNA or qHBsAG or ATL/AST or ... variation over time line?
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Avatar_m_tn

you know these tests there are so poor sensibility that i'd have the ng/ml type directly, now i dont remember the best machine but the old vit d tests were very very poor reliability

most vitamin d tests are not reliable with results, if i remember correct the ones doing ng/ml unit are those with higest sensibility, in any case if we stay well over 50ng/ml we are safely in the correct range
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Avatar_f_tn
I have collected my results as much as possible. I have been taking vitd3 and HepTec for about 8 weeks I think before I made my last test. I am also planning to take alinia after I get mutation and geno type results.  

Results on 21.11.08  

Albumin,  Bilirubin(Total),  Alpha-Foetoprotein --- Normal
Alt  55 ( Ref. 9-52 u/l ) ---- High
Ast  47 ( Ref. 14-36 u/l ) ---- High
HBsAG  6340 ( Ref. < 1.0 ) ---- Reactive
HBeAg  -------------------------Negative
Anti-HBe------------------------Positive
---------------------------------------------------------------------------------------------------
Results on 11.3.09

HBV DNA  446,574  copies/ml
Fibroscan -- 5.2 KPa
---------------------------------------------------------------------------------------------------
Results on 01.06.09

Albumin,  Bilirubin(Total),  Alpha-Foetoprotein --- Normal
Alt  62 ( Ref. 9-52 u/l ) ---- High
Ast  43 ( Ref. 14-36 u/l ) ---- High
HBsAG  5440 ( Ref. < 1.0 ) ---- Reactive
HBeAg  -------------------------Negative
Anti-HBe  0.77 ( Ref. < 1.2 )----Negative
Blood Report--------  RBC,  Platelet --- Normal
WBC -------------Monocytosis

-------------------------------------------------------------------------------------------------------

Results on 26.10.09

SGOT/AST-----53 u/l---- high-----15 - 41
SGPT/ALT-----54 u/l-----high-------0 - 44

HBV DNA   977,760  copies/ml

-------------------------------------------------------------------------------------------------------
Results on 4.1.2010

fibroscan ----- 3.7Kpa  

----------------------------------------------------------------------------------------------------
Results on (02-05-2011)

Total Protein-------  7.8 gm/dl---- normal-----( Ref.6.5 - 8.1 )
Albumin------------- 4.4 gm/ml ----normal----- ( Ref.3.5 - 4.8 )
Globulin------------- 3.4 gm/dl-----normal----- ( Ref.2.5 - 3.5 )
Direct Bilirubin----0.1  mg/dl-----normal----- ( Ref.0.1 - 0.5 )
Total Bilirubin------0.7  mg/dl-----normal----- ( Ref.0.4 - 2.0 )
Alk. Phosphatase--- 54 u/l -------normal----- ( Ref.38 - 126 )
SGOT/AST-----53 u/l---- high-----( Ref. 15 - 41 )
SGPT/ALT-----50 u/l-----high------( Ref. 0 - 44 )
Gamma GT----13 u/l-----normal--- ( Ref. 7 - 50 )
AFP 4.2 ng/ml------------ normal--- ( Ref. 0.0 - 9.0 )
ultrasound----normal
fibroscan----- 4.2 kpa

HbeAg Negative

hbv dan 1,775,100  copies/ml  (Test methodology by COBAS Ampliprep/COBAS TaqMan HBV Test)
Log equivalence 6.25 log
Viral Load (HBV DNA) =  305,000 iu/ml , Log equivalence = 5.48
-----------------------------------------------------------------------------------------------------------------------
Results on (26-09-2011) are as follows:

Fibroscan -- 4.6 kpa
HBV DNA --  55,814 copies/ml
HBsAg (Quantitative) --  2906.99 IU/ml (cut off= 0.05 IU/ml)
25OH Vitamin D3 --  40.8 ug/l

Total Protein-------  7.5 gm/dl---- normal-----( Ref.6.5 - 8.1 )
Albumin------------- 4.1 gm/ml ----normal----- ( Ref.3.5 - 4.8 )
Globulin------------- 3.4 gm/dl-----normal----- ( Ref.2.5 - 3.5 )
Direct Bilirubin----0.1  mg/dl-----normal----- ( Ref.0.1 - 0.5 )
Total Bilirubin------0.5  mg/dl-----normal----- ( Ref.0.4 - 2.0 )
Alk. Phosphatase--- 49 u/l -------normal----- ( Ref.38 - 126 )
SGOT/AST-----53 u/l---- high-----( Ref.15 - 41 )
SGPT/ALT-----54 u/l-----high-------( Ref.0 - 44 )
Gamma GT----14 u/l-----normal--- ( Ref.  7 - 50 )
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Avatar_f_tn
Thanks for the vit D sites. In-home testing kit might be very useful. I am thinking to buy one since it is also cheaper than the test in the hospital. I paid about 80 US$ for that test in the hospital.
I want to take alinia also after I know the mutation test results. Can you please give me the link of the company you order your alinia? Thanks, stef.





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Avatar_m_tn

this morning i called the virology lab at policlinico tor vergata...they do the whole hbv genome, not just the known resistant mutations

the 18th i will have the test done, all quasispecies of hbv will be detected in hbsag, core and polimerase, i was very surprised this test is available to all at that hospital
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1191262_tn?1366766621
Thanks for the info!
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Avatar_f_tn
Results are out.
My genotype is C. The one with higher hcc risk.

V 173 ---------wild type--- weakly intensity--- low
L180/A181---wild type--- strongly intensity--- high
N236 ---------wild type--- strongly intensity--- high
N236 ---------wild type--- strongly intensity--- high
T184  ---------wild type--- strongly intensity--- high
A194   ---------wild type--- strongly intensity--- high
S202  ---------wild type--- moderate intensity--- moderate
M250 ---------wild type--- moderate intensity--- moderate

Innolipa HBV Pre core Report

Conjugate control ------strongly intensity ---Interpretable Assay
Amp Control -------------high amplicons ------DNA Amplication successs
BCP (T1762/A1764)/ Mu ----------BCP mutant strongly intensity ----high
PC Codon 28 Mu----------------------PC mutant strongly intensity ----high

Stef, can you comment on my results?

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Avatar_m_tn

i'd strongly suggest to treat it and keep hbvdna und and alt normal.do you have family history of hcc?
i'd ask studyforhope opinion treat/not treat he is immensely more expert than me

BCP (T1762/A1764) this definitely requires treatment with genotype C, too increased liver cancer


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Avatar_m_tn

http://onlinelibrary.wiley.com/doi/10.1002/jmv.20175/abstract

Keywords:
HBV in Vietnam;HBV variant;corepromoter and precore mutant of HBV;HBV genotype
Abstract
In Asia, genotypes B and C are the most common genotypes of hepatitis B virus (HBV); and genotype C causes more severe liver disease. Core promoter/precore (CP/PC) mutants, known to be linked to these genotypes, could have an impact on the progression and severity of liver disease. Sera of 115 patients, including 39 acute and 76 chronic Vietnamese HBV infected patients, were tested for their liver profile, HBeAg, HBV genotypes, and HBV DNA level. Fragments of 282 nucleotides covering CP/PC were amplified, sequenced, and analysed. In the acute group, CP/PC mutants accounted for 38.4 and 25.6%, respectively. Genotype B was found to be predominant (74.3%, P < 0.05) and linked to the PC mutant (A1896) (P < 0.05). In the chronic group, CP/PC mutants accounted for 61.7 and 32.8%. CP mutants, especially the T1762/A1764 double mutant, were found to correlate with genotype C (81%, P < 0.001), liver cirrhosis, and hepatocellular carcinoma (P < 0.05). Therefore, genotype C in Vietnam, which carried high rate of C-1858 (70%), could play an important role in causing severe chronic liver disease. J. Med. Virol. 74:228–236, 2004. © 2004 Wiley-Liss, Inc.
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Avatar_m_tn
http://jvi.asm.org/cgi/reprint/78/16/8524.pdf


Basal Core Promoter and Precore Mutations in the Hepatitis B Virus
Genome Enhance Replication Efficacy of
Lamivudine-Resistant Mutant
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Avatar_m_tn
is this core or polimerase?

this looks polimerase mutants but they are too many, please ask studyforhope because i have these mutants reported differently at my hospital and i dont want to say uncorrect things.if all these are polimerase mutants i think it is best to use tenofovir+entecavir to be absolutely sure against any resistance or therapy failure

V 173 ---------wild type--- weakly intensity--- low
L180/A181---wild type--- strongly intensity--- high
N236 ---------wild type--- strongly intensity--- high
N236 ---------wild type--- strongly intensity--- high
T184  ---------wild type--- strongly intensity--- high
A194   ---------wild type--- strongly intensity--- high
S202  ---------wild type--- moderate intensity--- moderate
M250 ---------wild type--- moderate intensity--- moderate
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Avatar_m_tn

this is the way i usually see reports for polimerase:
rt q215q/s
rt N236
rt M250V

please report exactly all you have in the test report and ask studyforhope so that the best nuc can be chosen without any possibility of resistance
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Avatar_f_tn
Is there anyway that I can post a pdf file?
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Avatar_m_tn

email it to me then i check the polimerase positions or we ask studyforhope
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Avatar_m_tn
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Avatar_f_tn
4est
Thanks for the information.

stef2011
Thanks for your advice.
What's about peginterferon+etv+alinia+vitd3+heptec instead of tnf+heptec?
tnf reduces the bone density, right?   I have osteoporosis so this one might not be good for me. I know about side effects of peginterferon but may be I might have higher chance of cure???


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Avatar_m_tn

if you want to control hbv replication and no clearance, use only tnf+heptech
vitd3 and calcium can prevent osteoporosis and gcmaf might even cure it if your vdr is not ff/BB

if you want to clear hbsag, and i d try this one because you have about 2000iu/ml:
peginterferon+tnf+alinia+vitd3+simvastatin+heptec without fibroguard or no heptech

fibroguard lowers inflammation and in case you want to activate immune response by interferon it is better to keep inflammation too

entecavir may be used instead of tnf if you get sides on kidneys.as regards the combo of interferon+etv no clearance has been reported on the little clinical cases or trials available while interferon+tnf has many clinical cases and trials with hbsag clearance

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Avatar_f_tn
Thank , stef.
I'll discuss with my doctor here in my home country for peginterferon + tnf tx.
I'll post on different thread to let the other members know the higher risk genotype c has with bcp/cp mutants. May be studyforhope can comment on my results also for the knowledge of other members.
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Avatar_f_tn
You mentioned about your sister in the other post....

"by the way my sister gave up alinia, no response and increased vit d3 like you...she has decreased hbvdna to 88000iu/ml from millions in a couple of months
before this flare of hbvdna she had hbvdna stable for years at about 300000iu/ml, so both vit d and low choles might be helping on this "

I am happy to hear the news. But I am thinking to take alinia and now I am having the second thoughts.
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Avatar_m_tn

she used it monotherapy, until now we have data alinia can work only with interferon, it boosts interferon response probably it is able to decrease the interference viruses can make on interferon.using it with interferon is a very good thing since we have data on it
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Avatar_f_tn
Thank you for your clarification.
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Avatar_m_tn

and of course like for interferon we have seen alinia monotherapy working for low hbsag carriers like 1500iu/ml

there is a common pattern on all alinia users, mono or nucs combo, a decrease of hbsag about 50% in first months of use and then a relapse, probably the virus is able to adapt to this interfernce, so like on hcv studies it makes sense to start alinia before interferon for 4-12 weeks then when hbsag reaches the lowest level add the interferon before the relapse.
the combo alinia+interferon probably helps to block the virus interferonce on interferon pathways.
interferon responders are very low and the reason is hbv is able to stop interferon pathways, so any mean to weaken the virus before addition of interferon is good and we know:

high vitamin d >50ng/ml for both hbv and hcv
low cholesterol by simvastatin for hbv, fluvastatin for hcv (tot chol<150,ldl<70 while hdl value has little effect as interferon booster)
alinia for both hbv and hcv
coffee for both hbv and hcv

may be we will find in the future that also gcmaf can help repond better to interferon
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Avatar_m_tn
My Vitamin D Level was 32nmol/l(Not 32ng as I reported before)

I started Vitamin d3 10,000 iu/ml daily From 20/11/2010 up to 20/12/11 which is today.

I measured my vit d on 7/12/2011 which I got result today and it became 105 nmol/L which is only for three weeks and  I think If I measured today it will be more.

My Doctor advice me to stop and to drink a lot of water as I have got a mild headache.

He also asked me to have a calcium test which I did a blood test for today and I will get the result next week

Doctor told me the normal level is 80-150nmol
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Avatar_m_tn
CORRECTION

It si from 20/11/2011 NOT TO 2010
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Avatar_m_tn

you are still vit d deficent, the max value is 100ng/ml, possible increase of calcium after 350ng/ml (possible)
100ng/ml=249.6nmol/L

my god your doctor is incrdibly ingnorant, you are still vit d deficent, he doesnt even know the scales in nmol/l and ng/ml and doesnt even know what the normal values are and what toxicity is.
definitely change doctor or study the subject yourself

avoid tests in nmol/l, they are very old and not accurate, 105nmol/l is a low value, nmol/l is much lower than ng/ml and it is still used just to make confusion

how to make changes from ng/ml to nmol/l
http://www.globalrph.com/conv_si.htm

you must drink water only if calcium is high, not if vitamin d is high, drinking water has no effect on vitamin d but only on calcium.

as i said before check vit 25oh in ng/ml and calcium, if calcium gets over 15 you need to drink water.normal calcium is until about 10.5-11 but it is dangerous when it gets higher than 15
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Avatar_m_tn
do you also monitory also other HBV indicator (like HVB DNA , qHBsAg) before and after vit d supliments ?
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Avatar_m_tn

you need to reach at least:
50-70ng/ml  125-175nmol/l
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Avatar_m_tn

another thing to be stress, it doesn t exist vitamin d toxicity, there are only health problems due to low vitamin d in serum

please stop this stupid panic from drug makers to keep low vit D, there is no study that shows vitamin d toxicity, it just doesn t exsit.
there are only one or two reports of patients taking millions ui per day of vitamin d for over 6 months with an increased of calcium after having vitamin d 450-500ng/ml.they had no damage even from this
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Avatar_m_tn
I will try to  check again to somewhere else but uk is quite confusing to be honest with you, But my surprise is within 3 weeks from 32 nmol to 105 nmol even if i do not compare ng with nmol
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Avatar_m_tn

you are talking like if vitamin d is a poison, people on cirrhosis and cancer must take vitamin d and make it high.IT IS ONLY BENEFICIAL and also studies in san francisco has just proved how it protects from poisons and blocks cirrhosis development
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Avatar_m_tn
do you also monitory also other HBV indicator (like HVB DNA , qHBsAg) before and after vit d supliments

Not actually
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Avatar_m_tn
Thanks stef
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Avatar_m_tn

no i checked them every 3-4 months but vit d positive effect is proven by studies on antiviral activity of vit d on many viruses, hbv and hcv incuded
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Avatar_m_tn

if you see colombatto you can discuss everything about vit d with him, he of course knows how to deal with vit d and when it can be good or not

you can also test vit d when you are in pisa if it is not free in UK, in italy it goes from 16euro to 25euro according to the machines used.most of machines are not accurate in counting vit d accurately the newest and most accurate use something called chemioimmunescence or similar name but you can understand it those are the ones used because the range in updated to normal range 30-100ng/ml (some have still normal range 11-100ng/ml)
i have also found a few machines with normal range 30-60ng/ml, but again do not worry too much about those ranges, the latest normal range are 40-100ng/ml

unfortunately much scum and influence from drug makers has happened in vit d filed and we have to read studies ourselves to avoid the confusion.when vit d patent was rejected they did confunsion on studies and ranges and try to push use of synthetic vit d2 which is useless
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Avatar_m_tn

by the way if interferon is ever planned, interferon response gets higher in following cases:

vit d25oh>35ng/ml
tot chol<150mg/dl
ldl<80mg/dl

and of course alinia can boost interferon response by pkr
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Avatar_f_tn
Happy New Year everybody! Hopefully one year closer to absolute cure of our disease.

Results on (26-09-2011) are as follows:

Fibroscan -- 4.6 kpa
HBV DNA --  55,814 copies/ml
HBsAg (Quantitative) --  2906.99 IU/ml (cut off= 0.05 IU/ml)
25OH Vitamin D3 --  40.8 ug/l
SGOT/AST-----53 u/l---- high-----( Ref.15 - 41 )
SGPT/ALT-----54 u/l-----high-------( Ref.0 - 44 )


Latest results on (5-1-2012) are as follows:

Fibroscan -- Not done
HBV DNA --  473,748 copies/ml
HBsAg (Quantitative) --  3054.03 IU/ml (cut off= 0.05 IU/ml)
25OH Vitamin D3 --  59.4 ng/ml
SGOT/AST-----62 u/l---- high-----( Ref.15 - 41 )
SGPT/ALT-----63 u/l-----high-------( Ref.0 - 44 )

I am a little bit depressed because of the results. Vit D3 level is definitely up but hbvdna relaspe , I guess.



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Avatar_f_tn
I know,it is very disapointing. I came to the conclusion that the virus doesn't care no matter what we try do do, unless we are on treatment.
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Avatar_m_tn

the important thing is:
hbsag stays about the same so you are sure to get good results on treatment

do you have plans on alinia, tenofovir and interferon?

dont worry too much about hbvdna it has little or almost no meaning unless totally undetactable or close to undetactable, while hbsag is the most important
also high alt is important, it means your immune system can see the infected cells and kill them

i'd check again in 2-3 months and if hbsag rises i'd definitely start alinia and tenofovir and then just follow hbsag quantity for about a year and add interferon when hbsag gets close to 1500iu/ml or lower

the key is to keep an eye on hbsag and start a treatment before it moves to higher values which has no response to interferon.
hbsag values between 10.000 and 20.000iu/ml are almost sure to be non response to interferon as regards hbsag clearance
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Avatar_f_tn
lila58
You are right, it can be very disappointing and depressing.

stef2011
I'll check everything including fibroscan in March again and I'll probably start the treatment with entecavir which the doctor said I should start. I have ordered the alinia already; I'll receive them soon.
You mentioned somewhere that hbsag quantity relaspe after taking alinia for some time. Is it because of mono therapy?
My plan right now is in March I'll start with antiviral entecavir or tenefoir and about a year later add interferon. Just shortly before peg-interferon (may be 4 weeks before) I'll take alinia. The planning of how to start tx is really stressing me out.
At the moment I am taking Vit D3 8000iu and HepTec all 4 types.
Thank you, stef.


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Avatar_m_tn
if you use all 4 types, that means you consume around 7 capsules after each meal ..

i have only HepTech and Fibroguard, 4 capsules after each meal, alot of pills, i dont whether it work or not ..
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Avatar_m_tn
don't HepTech have vit d also ?
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Avatar_f_tn
OrientS
I take altogether 8 pills after breakfast and dinner only. Lunch time I take milk thistle and vit d3. Since you have a fibroscan result of only 2.3 kpa, just HepTec and Fibroguard should be working for you.

4est
Yes, vit d3 is also in HepTec. I take only vit D3 5000iu. With vitd3 from HepTec and calcium tablet which also contains vit d3, I consume about 8000iu of vit d3 a day.
My asthma is 99% gone now. This must be because of vitd3 and/or HepTec.
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Avatar_m_tn
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Avatar_f_tn
After long discussions and thinking, I am going to start treatment this Saturday, Pegasys + TDF treatment for 48 weeks. As Stef suggested before  I'll add Ntz also. (this would be without doctor's knowledge) and Vit D3.
@ stef..I have Nizonide 500 from Lupin. I should take 1 tablet a day after food right?

I'll keep you all informed my status.
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Avatar_m_tn

no 1 tablet would be just 500mg, not enough for antiviral effect.ntz stays in blood about 5hrs and effective doses were about 3g daily, so it is 1 pill at meals breakfast, lunch,dinner, before going to bed

ntz can have an effect on gut bacteria too so those with weak gut may have diarrea (diarrhea) for a few days (i was among these) so it is best to take probiotics or yogurt before starting ntz.i used home made bifidus yogurt and another probiotic i dont remember the name...it was used in ntz trials, the name is in old posts
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Avatar_m_tn

4-12 weeks of pretreatment with ntz monotherapy are very useful because it makes a drop of hbsag which allows a better intf response when it is added
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Avatar_f_tn
Oh...it's a bit late now. I am going to start all at one time.
I'll start taking NTZ tomorrow and evening I'll have Pegasys.
Thanks for the info. Hope you are doing well.
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Avatar_m_tn

well the 4 weeks lead in was on hcv trials, maybe it ll work the same on hbv even if starting all at the same time

as regards ntz i checked all trials done on this drug and it was very safe, the higher dosages had the highest response they just did not approve the 3-4g daily dosage because of the costs of big trials required by FDA but one trial in new york used the 4g daily dose on severe aids patients for over an year, soi think you can do just as i did and try doses between 3-4g daily by starting at around 2g daily and slowly increasing to 4g daily and see if you get any sides on gut or creatinine

i had both gut problems, solved by live probiotics and creatinine increase solved by use of fibroguard or coq10+nac antioxidants
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Avatar_m_tn
https://docs.google.com/open?id=0B_yFgxI8KNcRY1RfRXNlMFVxVWs

as a reference this is data from a guy adding ntz to intf, he started intf mono and had no response from intf, it looks like he ven had an hbvdna/hbsag increase
ntz add on looks like made an immediate effect on hbvdna, hbeag (hbsag not tested but when hbeag goes down hbsag goes dwon the same)

his doctor thought it was intf having this effect and put him on max intf dose, the sides were so heavy that this guy stopped all therapies, too bad we have such stupid doctors around.

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Avatar_f_tn
I'll start 2g of Ntz first as you suggest.
I am scared of the tx to be honest.
But I think it's time to do it now before it's too late.
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Avatar_m_tn

intf is the heavy one but it worths if hbsag goes down because a lifetime of antivirals whose sides longterm are unknown is not a good choice
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Avatar_f_tn
you are brave,I wish you good luck with treatment.I am scared to even start an antiviral.I just had a second fibroscan and is 3.7 kpa,I hope it is what it says.Please keep us dated.
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Avatar_m_tn

do you have baseline hbeag and hbsag quantity?so we get to know the chances of clearance
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Thank you all for your support.

Latest results on March 2012 ..are as follows:

Fibroscan -- 4.2 kpa
HBV DNA --  450,897 copies/ml
HBsAg (Quantitative) --  3054.03 IU/ml (cut off= 0.05 IU/ml)
Hbeag - Negative
anti-Hbe - Positive
SGOT/AST-----85 u/l---- high
SGPT/ALT-----63 u/l-----high

I'll keep you updated.
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I had first Pegasys shot on Saturday. Felt like I had the worst flu of my life.
Doctor told me to take Paracetamal if I couldn't stand it..I took just one in the end..
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same as my imiquimod when taken suppository, i have to rest in bed most of the day and take paracetamol because pains are all over, even the skin

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omg.. so far I never experenced this... even if my blood counts it's really out of range meaning I do have sides...

come on April!!! do not quit!!,,, straigth to the end.. and your hbs does not seem too high.. isnt it??
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I wish you all the best.  Please keep us updated.
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Keep Pushing it April. I am about to start INTF too. Pls keep up posted on ur progress. Like to know do the sides still persist? Any more concerns?
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I had second shot today!
Let's see what's going to happen tonight.
@ grmr...I'll not quit. You don't have sides because may be you are younger. I'll let you all know tomorrow how I feel over night.

Thank you all so much. It's good to know that you are not fighting alone.
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Last night after secont shot of Pegasys, I felt nothing..It was normal..I also feel fine this morning. Hopefully it stays like this for future shots.
@ joc2011..Good luck with your treatment.
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