Results after about 2 months of VitD3 5000iu and heptec

[April9903]

In April my viral load was 1.7 mil copies/ml.

the results now:-
Fibroscan -- 4.6 kpa
HBV DNA --  55,814 copies/ml
HBsAg (Quantitative) --  2906.99 IU/ml (cut off= 0.05 IU/ml)
25OH Vitamin D3 --  40.8 ug/l

Alt -- 54 u/l -----high (normal 0 - 44)
Ast -- 53 u/l ----high (normal 15 - 41)

Genotype, Precore Mutation, Polemerase mutation have to wait about 2 weeks.
My alt, art is always a little bit high. My doctor already wanted to treat me and she said I have about 50% chance now if I make peg interferon treatment. But I told her I wanted to wait for the time being.
I think vitD3 or heptec or both helped me in dropping so much hbv dna.

my alt and art is high like this for about 2-3 years I think.

[April9903]

Last night after secont shot of Pegasys, I felt nothing..It was normal..I also feel fine this morning. Hopefully it stays like this for future shots.
@ joc2011..Good luck with your treatment.

[April9903]

I had second shot today!
Let's see what's going to happen tonight.
@ grmr...I'll not quit. You don't have sides because may be you are younger. I'll let you all know tomorrow how I feel over night.

Thank you all so much. It's good to know that you are not fighting alone.

[joc2011]

Keep Pushing it April. I am about to start INTF too. Pls keep up posted on ur progress. Like to know do the sides still persist? Any more concerns?

[calmama]

I wish you all the best.  Please keep us updated.

[grmr]

omg.. so far I never experenced this... even if my blood counts it's really out of range meaning I do have sides...

come on April!!! do not quit!!,,, straigth to the end.. and your hbs does not seem too high.. isnt it??

[stef2011]

same as my imiquimod when taken suppository, i have to rest in bed most of the day and take paracetamol because pains are all over, even the skin

[April9903]

I had first Pegasys shot on Saturday. Felt like I had the worst flu of my life.
Doctor told me to take Paracetamal if I couldn't stand it..I took just one in the end..

[April9903]

Thank you all for your support.

Latest results on March 2012 ..are as follows:

Fibroscan -- 4.2 kpa
HBV DNA --  450,897 copies/ml
HBsAg (Quantitative) --  3054.03 IU/ml (cut off= 0.05 IU/ml)
Hbeag - Negative
anti-Hbe - Positive
SGOT/AST-----85 u/l---- high
SGPT/ALT-----63 u/l-----high

I'll keep you updated.

[stef2011]

do you have baseline hbeag and hbsag quantity?so we get to know the chances of clearance

[lila58]

you are brave,I wish you good luck with treatment.I am scared to even start an antiviral.I just had a second fibroscan and is 3.7 kpa,I hope it is what it says.Please keep us dated.

[stef2011]

intf is the heavy one but it worths if hbsag goes down because a lifetime of antivirals whose sides longterm are unknown is not a good choice

[April9903]

I'll start 2g of Ntz first as you suggest.
I am scared of the tx to be honest.
But I think it's time to do it now before it's too late.

[stef2011]

https://docs.google.com/open?id=0B_yFgxI8KNcRY1RfRXNlMFVxVWs

as a reference this is data from a guy adding ntz to intf, he started intf mono and had no response from intf, it looks like he ven had an hbvdna/hbsag increase
ntz add on looks like made an immediate effect on hbvdna, hbeag (hbsag not tested but when hbeag goes down hbsag goes dwon the same)

his doctor thought it was intf having this effect and put him on max intf dose, the sides were so heavy that this guy stopped all therapies, too bad we have such stupid doctors around.

[stef2011]

well the 4 weeks lead in was on hcv trials, maybe it ll work the same on hbv even if starting all at the same time

as regards ntz i checked all trials done on this drug and it was very safe, the higher dosages had the highest response they just did not approve the 3-4g daily dosage because of the costs of big trials required by FDA but one trial in new york used the 4g daily dose on severe aids patients for over an year, soi think you can do just as i did and try doses between 3-4g daily by starting at around 2g daily and slowly increasing to 4g daily and see if you get any sides on gut or creatinine

i had both gut problems, solved by live probiotics and creatinine increase solved by use of fibroguard or coq10+nac antioxidants

[April9903]

Oh...it's a bit late now. I am going to start all at one time.
I'll start taking NTZ tomorrow and evening I'll have Pegasys.
Thanks for the info. Hope you are doing well.

[stef2011]

4-12 weeks of pretreatment with ntz monotherapy are very useful because it makes a drop of hbsag which allows a better intf response when it is added

[stef2011]

no 1 tablet would be just 500mg, not enough for antiviral effect.ntz stays in blood about 5hrs and effective doses were about 3g daily, so it is 1 pill at meals breakfast, lunch,dinner, before going to bed

ntz can have an effect on gut bacteria too so those with weak gut may have diarrea for a few days (i was among these) so it is best to take probiotics or yogurt before starting ntz.i used home made bifidus yogurt and another probiotic i dont remember the name...it was used in ntz trials, the name is in old posts

[April9903]

After long discussions and thinking, I am going to start treatment this Saturday, Pegasys + TDF treatment for 48 weeks. As Stef suggested before  I'll add Ntz also. (this would be without doctor's knowledge) and Vit D3.
@ stef..I have Nizonide 500 from Lupin. I should take 1 tablet a day after food right?

I'll keep you all informed my status.

[4est]

http://www.medhelp.org/posts/Hepatitis-B/Vitamin-D---again-/show/1667443

[April9903]

OrientS
I take altogether 8 pills after breakfast and dinner only. Lunch time I take milk thistle and vit d3. Since you have a fibroscan result of only 2.3 kpa, just HepTec and Fibroguard should be working for you.

4est
Yes, vit d3 is also in HepTec. I take only vit D3 5000iu. With vitd3 from HepTec and calcium tablet which also contains vit d3, I consume about 8000iu of vit d3 a day.
My asthma is 99% gone now. This must be because of vitd3 and/or HepTec.

[4est]

don't HepTech have vit d also ?

[OrientS]

if you use all 4 types, that means you consume around 7 capsules after each meal ..

i have only HepTech and Fibroguard, 4 capsules after each meal, alot of pills, i dont whether it work or not ..

[April9903]

lila58
You are right, it can be very disappointing and depressing.

stef2011
I'll check everything including fibroscan in March again and I'll probably start the treatment with entecavir which the doctor said I should start. I have ordered the alinia already; I'll receive them soon.
You mentioned somewhere that hbsag quantity relaspe after taking alinia for some time. Is it because of mono therapy?
My plan right now is in March I'll start with antiviral entecavir or tenefoir and about a year later add interferon. Just shortly before peg-interferon (may be 4 weeks before) I'll take alinia. The planning of how to start tx is really stressing me out.
At the moment I am taking Vit D3 8000iu and HepTec all 4 types.
Thank you, stef.

[stef2011]

the important thing is:
hbsag stays about the same so you are sure to get good results on treatment

do you have plans on alinia, tenofovir and interferon?

dont worry too much about hbvdna it has little or almost no meaning unless totally undetactable or close to undetactable, while hbsag is the most important
also high alt is important, it means your immune system can see the infected cells and kill them

i'd check again in 2-3 months and if hbsag rises i'd definitely start alinia and tenofovir and then just follow hbsag quantity for about a year and add interferon when hbsag gets close to 1500iu/ml or lower

the key is to keep an eye on hbsag and start a treatment before it moves to higher values which has no response to interferon.
hbsag values between 10.000 and 20.000iu/ml are almost sure to be non response to interferon as regards hbsag clearance