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SINGAPORE MAKES SIGNIFICANT STEPS- HBV
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SINGAPORE MAKES SIGNIFICANT STEPS- HBV

Home > Breaking News > Singapore > Story
March 19, 2009
Possible cure for Hepatitis B  
By Amresh Gunasingham  
  
Twleve researchers from A*Star and NUS have developed antibodies which could cure chronic hepititis (hepatitis) B. -- PHOTO: SPH

RESEARCHERS in Singapore are developing a treatment which could eventually lead to a cure for chronic hepatitis B (HBV), the leading cause of liver cancer in Singapore.
Present medication can control the virus but cannot cure the infection.

Their research was highlighted this week in a two-day conference at the Biopolis, which attracted eminent scientists from Singapore and Britain.

Twelve researchers from the Agency for Science, Technology and Research (A*Star) and National University of Singapore (NUS) have developed antibodies which can enhance the delivery of drugs to cells in the body infected by the HBV virus.

'Current anti-viral treatment, while effective in curbing the replication of the virus, cannot eliminate the infection entirely,' said Professor Antonio Bertoletti, principal investigator at the Singapore Institute for Clinical Sciences at A*Star, who is leading the research effort which started two years ago.

Patients have chronic hepatitis B because they are unable to make antibodies which can recognise and fight off the virus, the researchers concluded. To overcome this, they developed a compound which when injected into a patient, can 'reprogram' the immune system to recognise cells infected by the virus.

The compound uses virus-fighting T-cells from patients who have been cured of the virus. The injected antibodies can carry the drug into the infected cells. The method has been used in cancer therapy.

But a viable treatment remains at least 'two to three years' away as tests are still being conducted on animals.

Associate Professor Lim Seng Gee, Chief of Hepatology at National University Hospital, said the project could be a 'major breakthrough' as the role of the immune system in controlling the HBV virus is 'still not well understood'.

'There is no cure for hepatitis B, so the next stage of medical advancement will be to develop a treatment to remove the virus completely from the liver,' he said.

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13 Comments Post a Comment
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Avatar_m_tn
Exciting!
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Avatar_m_tn
raising my hands up and asking God for this to come true.. one day soon

very exciting find. thank you jack1642
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Avatar_m_tn
love this
just got tested for acute hbv
Im keeping my head up and hoping for the best
this will help humanity all together if its achieved
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Avatar_m_tn
Thats great news bud.... if this comes true i'm buying the first pints for every1.....
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Avatar_f_tn
FANTASTIC!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! Oh I really hope they get the cure to eradicate this wee sod once and for all.
Brit
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Avatar_f_tn
dis will be GREAT... i will consider this my second life....TO THE TWELVE RESEARCHERS WITH ALL MY HEART I TRUST ALL OF YOU...hoping and praying that one day HBV IS CURABLE.......
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Avatar_f_tn
please keep us updated with this... God is good!!! 350 million people are waiting for this development..

God bless us all...
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Avatar_f_tn
i am just wondering why could we just not use the hepatitis b immune globulin available in the market and inject it to those with chronic infection until it binds all the circulating surface antigens in the blood? this approach is somewhat similar to the research in this post don't you think?.
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Avatar_m_tn
Once infest ed none of the medications available will cure you. Though you have apoint , medical science does not think it will work. A cure I think is not far away. Lets pray for more funding and researches taking interest in our case.
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Avatar_m_tn
anything new?
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Avatar_f_tn
sana po maka discover na talaga ng gamot..thank you po...
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Avatar_m_tn
this was looking good back in 2009.
Some news regarding this ?
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Avatar_m_tn
http://jvi.asm.org/cgi/content/abstract/85/5/1935

this is the 2011 article
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