SVR increase on hcv trial vs vit d level chol level
since we haven t yet results on hbv we can relay on hcv studies, best response on:
vitamin d 25oh>42ng/ml
ldl400,000 IU/l) and high fibrosis score (Metavir scores >F2) in 50%, 40%, and 30% respectively.
Overall, 42 % of patients were responders. Responders had significantly lower serum cholesterol levels (152±43 Vs 181±33 mg%, P=0.01), lower LDL levels (83±31 Vs 104±29, mg%, P=0.008), lower HDL levels (42±14 Vs 50±10, mg%, P=0.009), and higher vitamin D levels (42.1±6.0 Vs 27.3±5.2 ng/ml, P0.05). Multivariate logistic regression analysis showed that gender (Women, OR 2.3, P< 0.001), low cholesterol levels (180mg/dL; OR 2.5, P< 0.03), low HDL (40 mg/dL, OR 3.5, P< 0.001), and high vitamin D levels ( 20 ng/ml, OR 3.8, P< 0.001) are strongly associated with SVR.
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