SVR increase on hcv trial vs vit d level chol level

[stef2011]

since we haven t yet results on hbv we can relay on hcv studies, best response on:
vitamin d 25oh>42ng/ml
tot chol<152
ldl400,000 IU/l) and high fibrosis score (Metavir scores >F2) in 50%, 40%, and 30% respectively.

Overall, 42 % of patients were responders. Responders had significantly lower serum cholesterol levels (152±43 Vs 181±33 mg%, P=0.01), lower LDL levels (83±31 Vs 104±29, mg%, P=0.008), lower HDL levels (42±14 Vs 50±10, mg%, P=0.009), and higher vitamin D levels (42.1±6.0 Vs 27.3±5.2 ng/ml, P0.05). Multivariate logistic regression analysis showed that gender (Women, OR 2.3, P< 0.001), low cholesterol levels (180mg/dL; OR 2.5, P< 0.03), low HDL (40 mg/dL, OR 3.5, P< 0.001), and high vitamin D levels ( 20 ng/ml, OR 3.8, P< 0.001) are strongly associated with SVR.

[stef2011]

vitamin d at 50-80ng/ml,

tot chol less than 150, ldl less than 80 and hdl as high as possible minimum 50men, 60 women

puritans pride has vit d3 5000iu they are better absorbed with food

[raja1972]

Hi Stefano,
Can you please simply put the required levels for D and CHOL to benefit all?


Thanks
Raja

[stef2011]

vitamin d 25oh 30-100ng/ml is also extremely important to avoid liver damage/fibrosis

http://www.viraled.com/modules/info/files/files_4dbeda6600d27.pdf

[stef2011]

it is extremely important to reach these values, especially for those using immune modulating therapies like interferon or alinia (nitazoxanide) to have higher chances of hbsag negative