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Sebivo(Telviduine) Efficacy
Hello all
Is anyone using telviduine, if so please tell me the efficacy of this medicine and side effects?
Is anyone using telviduine, if so please tell me the efficacy of this medicine and side effects?
size and contour of liver is normal and all the readings is normal. Still doctor wanted to wait for 2 months, as per his analysis if resistance occurs that would be for ltd not for all. Resistance will be decided if the viral increases during treatment.
wasted time, drug is not firstline because it doesn t work, too weak, so there is a valid reason not to use it for us all.if hbvdna increases too much it will take longer to get it down but tenofovir will work anyway 100% the mutation can be the same as LAM mutation (they share some mutants)
is your doc paid by sebvivo makers or making trials for them?
by the way drug has been a total failure why wait?
wasted time, drug is not firstline because it doesn t work, too weak, so there is a valid reason not to use it for us all.if hbvdna increases too much it will take longer to get it down but tenofovir will work anyway 100% the mutation can be the same as LAM mutation (they share some mutants)
is your doc paid by sebvivo makers or making trials for them?
by the way drug has been a total failure why wait?
Platelet Count: 215.0 thou/mm3 (150.0 - 450.0)
US Abdomen enthrogram with avic reading is 0.84 to 1.34
size and contour of liver is normal and all the readings is normal. Still doctor wanted to wait for 2 months, as per his analysis if resistance occurs that would be for ltd not for all. Resistance will be decided if the viral increases during treatment.
I am confused about the situtation. My new doctor is out of station i will start the tenofovir or interferon under his assistance.
Thanks for your comments. God bless all.
US Abdomen enthrogram with avic reading is 0.84 to 1.34
size and contour of liver is normal and all the readings is normal. Still doctor wanted to wait for 2 months, as per his analysis if resistance occurs that would be for ltd not for all. Resistance will be decided if the viral increases during treatment.
I am confused about the situtation. My new doctor is out of station i will start the tenofovir or interferon under his assistance.
Thanks for your comments. God bless all.
this is really a silet killer, my cirrhosis was clear from fibroscan and ultrasound only, all blood tests were pretty normal except alt and hbvdna
also check platlets, they are low on severe fibrosis/cirrhosis but again low plt is already advanced cirrhosis, i never had abnormal platlets even being on cirrhosis
do not expect synthoms even when close to death, this is a silent killer, always refer to blood tests not what you feel
HDL 34 mg/dL (40 - 60)
LDL 106 mg/dL (<100)
see if you can improve hdl good cholesterol by diet and also lower bad cholersterol ldl.there is a connection between immune system, fat liver disease and cholesterol, soya, fish oil, vegetables, less meat and fats helps
alt way too high
Bilirubin, Total 1.70 mg/dL (<1.00)
Bilirubin, direct 0.20 mg/dL (<0.30)
Bilirubin Indirect 1.50 mg/dL (<0.70)
bilirubin reflects liver function, i have cirrhosis but never had abnormal bilirubin in my life, check liver damage by fibroscan, this is a bad sign because liver is not working well
Prothrombin Time Studies:
Mean Normal Prothrombin Time 14:00 sec
On patients blood 18:00 sec (10 - 15.6)
this is also a sign of severe fibrosis, again i have cirrhosis but never had abnoraml PT
PT and bilirubin are the most important for liver function, did you check liver by fibroscan for cirrhosis?
HBV DNA: 449 IU/ml
my god this is way too high, make resistance test and start tenofovir right away, do not wait for resistance test to start tenofovir that's the only one who works with resistance strains.Once you know resistance result start a combo, probability of resistance mutation is high i remember your are on ltd long time
interferon is the right choice if you don t have cirrhosis, make nitazoxanide+peginterferon after you have finished interferon make ntz+tenofovir
Hello Stefano/All
I have visited a new doctor and he is also not satisfied with the way i treated with sebivo for one year. As per my new doctor i have made the below labs,
please have a look and suggest me about my condition, i don't have any kind of symptoms as of now.
CBC(complete blood count): Every reading is normal
Lipid Profile: Cholestrol 160 mg/dL (< 200)
Triglycerides 98 mg/dL ( 150.00)
HDL 34 mg/dL (40 - 60)
LDL 106 mg/dL (<100)
TSH 0.96 uIU.mL (0.35 - 5.50)
LFTs:
SGPT (ALT) 75 U/L (<43)
SGOP(AST) 38 U/L (< 37)
GGTP 35 U/L (8 - 61)
ALP 117 U/L (110 - 310)
Bilirubin, Total 1.70 mg/dL (<1.00)
Bilirubin, direct 0.20 mg/dL (<0.30)
Bilirubin Indirect 1.50 mg/dL (<0.70)
Protein, Total 7.40 g/dL (6.40 - 8.30)
Albumin 4.20 g/dL (3.50 - 5.20)
A: G ratio 1.31 (0.9 - 2.00)
Prothrombin Time Studies:
Mean Normal Prothrombin Time 14:00 sec
On patients blood 18:00 sec (10 - 15.6)
HbA1c 4.20 (4.27 - 6.07)
HBV DNA: 449 IU/ml
Linear Reporting range (20 IU/mL to 1.70x10 power 8 IU/mL)
1. Is these reports suggest the reactivation of the HBV DNA?
2. Bilirubin is elevated, what would be the impact?
3. My SGPT and SGOT keep going up, what would be the impact?
4. How safe my life partner would be if I marry at this point of time ?
I am waiting to visit my doctor, as he is out of town. As per his plan he will use interferon theraphy, how correct to use interferon at this point of time. I am male, 28 yrs from india.
Please help.
Thank you.
T
I have visited a new doctor and he is also not satisfied with the way i treated with sebivo for one year. As per my new doctor i have made the below labs,
please have a look and suggest me about my condition, i don't have any kind of symptoms as of now.
CBC(complete blood count): Every reading is normal
Lipid Profile: Cholestrol 160 mg/dL (< 200)
Triglycerides 98 mg/dL ( 150.00)
HDL 34 mg/dL (40 - 60)
LDL 106 mg/dL (<100)
TSH 0.96 uIU.mL (0.35 - 5.50)
LFTs:
SGPT (ALT) 75 U/L (<43)
SGOP(AST) 38 U/L (< 37)
GGTP 35 U/L (8 - 61)
ALP 117 U/L (110 - 310)
Bilirubin, Total 1.70 mg/dL (<1.00)
Bilirubin, direct 0.20 mg/dL (<0.30)
Bilirubin Indirect 1.50 mg/dL (<0.70)
Protein, Total 7.40 g/dL (6.40 - 8.30)
Albumin 4.20 g/dL (3.50 - 5.20)
A: G ratio 1.31 (0.9 - 2.00)
Prothrombin Time Studies:
Mean Normal Prothrombin Time 14:00 sec
On patients blood 18:00 sec (10 - 15.6)
HbA1c 4.20 (4.27 - 6.07)
HBV DNA: 449 IU/ml
Linear Reporting range (20 IU/mL to 1.70x10 power 8 IU/mL)
1. Is these reports suggest the reactivation of the HBV DNA?
2. Bilirubin is elevated, what would be the impact?
3. My SGPT and SGOT keep going up, what would be the impact?
4. How safe my life partner would be if I marry at this point of time ?
I am waiting to visit my doctor, as he is out of town. As per his plan he will use interferon theraphy, how correct to use interferon at this point of time. I am male, 28 yrs from india.
Please help.
Thank you.
T
for example after 7 months of etv my alt is still 36 and hvbdna between 1 and 20 iu/ml, of course hbvdna in the liver is still positive.if i don t get hbvdna und and alt lower than 30 by 8-9 months i will add tenofovir or interferon
forgot to tell you my hbcab igm, it was 0.15s/co at 6 months with hbvdna 38iu/ml, it is used to monitor hbv reactivation since when hbvdna is und in the blood hbcab igm is the forst value to rise before hbvdna and alt.of course my target is hbcab igm<0.081s/co by at least 1 year
forgot to tell you my hbcab igm, it was 0.15s/co at 6 months with hbvdna 38iu/ml, it is used to monitor hbv reactivation since when hbvdna is und in the blood hbcab igm is the forst value to rise before hbvdna and alt.of course my target is hbcab igm<0.081s/co by at least 1 year
your doctor is not expert enough, hbvdna negative in the blood doesn t mean hbvdna is negative in the liver, on the contrary it is almost always positive even if hbvdna is und in the blood
since alt/ast are still elevated your hbvdna in the liver is high and suppression didn t work, it is very difficult that elevated alt are due to your immune system that can see cccdna in the liver cells
there are 3 tests to clear this:
research level cccdna in the blood, if you find cccdna in mononuclear cells in the blood your hbv is still very active.specialized labs in asia and europe do this, if yo are in US/canada i don t think you will find a lab to do this but only research centers
biopsy, you will know everything but again it must be a specialized hospital to detect hbvdna in the liver, hbvdna in the cells, cccdna
hbcab Igm if lower than 0.2s/co hbv is inactive but still grey zone result and if lower than 0.081s/co almost 100% security of inactive hbv.
for example after 7 months of etv my alt is still 36 and hvbdna between 1 and 20 iu/ml, of course hbvdna in the liver is still positive.if i don t get hbvdna und and alt lower than 30 by 8-9 months i will add tenofovir or interferon
but i'd rather make tenfovir+nitazoxanide because telbivudine has totally failed it is useless to check hbvdna in the blood since it must be und by 12-24 weeks to say drug failed and the probability it is high in the liver is too much, your alt/ast are still abnormal after more than 1 year and hbsag level did not change another failure
since alt/ast are still elevated your hbvdna in the liver is high and suppression didn t work, it is very difficult that elevated alt are due to your immune system that can see cccdna in the liver cells
there are 3 tests to clear this:
research level cccdna in the blood, if you find cccdna in mononuclear cells in the blood your hbv is still very active.specialized labs in asia and europe do this, if yo are in US/canada i don t think you will find a lab to do this but only research centers
biopsy, you will know everything but again it must be a specialized hospital to detect hbvdna in the liver, hbvdna in the cells, cccdna
hbcab Igm if lower than 0.2s/co hbv is inactive but still grey zone result and if lower than 0.081s/co almost 100% security of inactive hbv.
for example after 7 months of etv my alt is still 36 and hvbdna between 1 and 20 iu/ml, of course hbvdna in the liver is still positive.if i don t get hbvdna und and alt lower than 30 by 8-9 months i will add tenofovir or interferon
but i'd rather make tenfovir+nitazoxanide because telbivudine has totally failed it is useless to check hbvdna in the blood since it must be und by 12-24 weeks to say drug failed and the probability it is high in the liver is too much, your alt/ast are still abnormal after more than 1 year and hbsag level did not change another failure
As on 04-July-2010 reports:
HBV DNA: Sample is negative for HBV DNA
Detection Range is <6IU/ml to 110000000 IU/ml
SGPT 61
SGOT 37
09-Aug-2010 Reports:
SGPT 72
SGOT 43
As per my doctor he wanted me to check my HBV DNA on first week of Oct-2010, but to be in safer side i am planning to done it in this month.
HBV DNA: Sample is negative for HBV DNA
Detection Range is <6IU/ml to 110000000 IU/ml
SGPT 61
SGOT 37
09-Aug-2010 Reports:
SGPT 72
SGOT 43
As per my doctor he wanted me to check my HBV DNA on first week of Oct-2010, but to be in safer side i am planning to done it in this month.
etv and tdf lower hbsag on about 17% patients 0,5log per year, telbivudine maybe on more than 17% but too little studies, on the opposite hbv resistance is a bad issue on this drug, only hbvdna und by 12-24weeks can be considered safe on this drug
i'd add ntz just to see if hbsag decreases faster, in my combo etv+ntz hbsag lowered to 50% less n 4 weeks
as to your question on hbsag:
is hbsag unit in iu/ml?
i m sorry 184iu/ml is less than nothing even in one month.
adding nitazoxanide i had about 2600iu/ml decrease in 4 weeks
Is my immune system clearing the HBsAg as per the latest hbsag reports?
no, you can have 500iu/ml and more flactuation of hbsag even from day to day, it is different from hbvdna and alt and can have ups and down
2. Can wait for some more time to start alinia or combo with tenofovir?
i'd not wait any more minute since resistance if the most dangerous thing that can happen
as i know it is not safe to switch from an antiviral to another and you should combo at least one month telbivudine+tnf
3. Any chances of HBsAg negative?
as i said above 184iu/ml is almost steady evem if it was 4 weeks and not years
how's your hbvdna and alt now?
Hi
Please see my Latest HBsAg test results during and after the treatment.
On Sebivo for one year
Treatment start Date: June-2009
Treatment End Date: 04-July-2010
During treatment April-2010 HBSAG 1375
Aug-2010 HBSAG 1191
As per your previous reply:
another theory is that the imune system is clearing liver cells with cccdna, but i don t believe this, in this case you just check hbsag and see if it is decreasing.according to me 99% is a failure of the drug to clear hbvdna in the liver.
Question: 1. Is my immune system clearing the HBsAg as per the latest hbsag reports?
2. Can wait for some more time to start alinia or combo with tenofovir?
3. Any chances of HBsAg negative?
Thank you for your support.
Please see my Latest HBsAg test results during and after the treatment.
On Sebivo for one year
Treatment start Date: June-2009
Treatment End Date: 04-July-2010
During treatment April-2010 HBSAG 1375
Aug-2010 HBSAG 1191
As per your previous reply:
another theory is that the imune system is clearing liver cells with cccdna, but i don t believe this, in this case you just check hbsag and see if it is decreasing.according to me 99% is a failure of the drug to clear hbvdna in the liver.
Question: 1. Is my immune system clearing the HBsAg as per the latest hbsag reports?
2. Can wait for some more time to start alinia or combo with tenofovir?
3. Any chances of HBsAg negative?
Thank you for your support.
HBV DNA: Sample is negative for HBV DNA
Detection Range is <6IU/ml to 110000000 IU/ml
these are very abnormal for hbvdna und.hbvdna in the serum usually reflects hbvdna intra and extra cellular in the liver but not always, these might be your case.
another theory is that the imune system is clearing liver cells with cccdna, but i don t believe this, in this case you just check hbsag and see if it is decreasing.according to me 99% is a failure of the drug to clear hbvdna in the liver.
SGPT 61
SGOT 37
As per my doctors plan, he want to start the Tenofovir depends on the HBV DNA load after 3 months.
i do suggest to start alinia before tenofovir and check hbsag if decreasing, add tenofovir after 4 weeks
alt values are not important using immune modulators, in this case you have to chck hbsag only and hbvdna.you should get norml alt within 24 weeks by alinia alone or combo alinia+tenofovir after alt are normal also bilirubin will get to normal
yes your doctor is right if your liver has no cirrhosis alt and bilirubin are not important at all and will get to normal with your new drugs.
the only thing very important i to start alinia before tenofovir, it is also good to wait sometime before starting alinia so that you build some immune response
Detection Range is <6IU/ml to 110000000 IU/ml
these are very abnormal for hbvdna und.hbvdna in the serum usually reflects hbvdna intra and extra cellular in the liver but not always, these might be your case.
another theory is that the imune system is clearing liver cells with cccdna, but i don t believe this, in this case you just check hbsag and see if it is decreasing.according to me 99% is a failure of the drug to clear hbvdna in the liver.
SGPT 61
SGOT 37
As per my doctors plan, he want to start the Tenofovir depends on the HBV DNA load after 3 months.
i do suggest to start alinia before tenofovir and check hbsag if decreasing, add tenofovir after 4 weeks
alt values are not important using immune modulators, in this case you have to chck hbsag only and hbvdna.you should get norml alt within 24 weeks by alinia alone or combo alinia+tenofovir after alt are normal also bilirubin will get to normal
yes your doctor is right if your liver has no cirrhosis alt and bilirubin are not important at all and will get to normal with your new drugs.
the only thing very important i to start alinia before tenofovir, it is also good to wait sometime before starting alinia so that you build some immune response
Hi
Please find my June 2010 reports, i was on Sebivo for one year after the below reports my doctor suggested me to stop Sebivo, and told me to visit after 3 months with HBV DNA report.
HBV DNA: Sample is negative for HBV DNA
Detection Range is <6IU/ml to 110000000 IU/ml
SGPT 61
SGOT 37
Serum Creatinine: 1.0 mg/dl
HBsAg: Positive
HBeAg: Negative
Anti HBe: Positive
Total Bilirubin 2.0 mg/dL Ref range: 0.3 to 1.2
Direct Bilirubin: 0.6 mg/dL Ref range: upto 0.2
Indirect bilirubin: 1.4 mg/dL
As per my doctors plan, he want to start the Tenofovir depends on the HBV DNA load after 3 months.
Could you please comment on the above reports and also suggest me the usage of Alinia.
What would be the impact of elevated Bilirubin values and SGPT, as per doctor i should not bother about these values and i am in a good health condition.
Thank YOu
Please find my June 2010 reports, i was on Sebivo for one year after the below reports my doctor suggested me to stop Sebivo, and told me to visit after 3 months with HBV DNA report.
HBV DNA: Sample is negative for HBV DNA
Detection Range is <6IU/ml to 110000000 IU/ml
SGPT 61
SGOT 37
Serum Creatinine: 1.0 mg/dl
HBsAg: Positive
HBeAg: Negative
Anti HBe: Positive
Total Bilirubin 2.0 mg/dL Ref range: 0.3 to 1.2
Direct Bilirubin: 0.6 mg/dL Ref range: upto 0.2
Indirect bilirubin: 1.4 mg/dL
As per my doctors plan, he want to start the Tenofovir depends on the HBV DNA load after 3 months.
Could you please comment on the above reports and also suggest me the usage of Alinia.
What would be the impact of elevated Bilirubin values and SGPT, as per doctor i should not bother about these values and i am in a good health condition.
Thank YOu
Thank you Stefano
My next doc review is on June 2010, I will discuss with my doc about using alinia in case the treatment ends based on the reports. I will share the reports with you.
Have a nice day and happy life.
My next doc review is on June 2010, I will discuss with my doc about using alinia in case the treatment ends based on the reports. I will share the reports with you.
Have a nice day and happy life.
it should mean und, 3 is probably the limit of detection of the essay.
after you reach und you can monitor hbsag and hbeag titer to understand if antiviral is still working or just reached its maximum with hbvdna und.of course checking titers from baseline is much better but if you see hbsag going down is a good sign
alt is still abnormal, it is also better to have normal alt after a few month you are und
Hi Stefano
Thank you so much for information.
My latest HBVDNA readings as follows:
Jan-2010 HBVDNA < 3IU/ml and SGPT 72
Oct-2009 HBVDNA < 3IU/ml
Could you please let me know, is <3 IU/ml means UND or still positive.
My Hbeag -ve before treatment started.
Thank you
Thank you so much for information.
My latest HBVDNA readings as follows:
Jan-2010 HBVDNA < 3IU/ml and SGPT 72
Oct-2009 HBVDNA < 3IU/ml
Could you please let me know, is <3 IU/ml means UND or still positive.
My Hbeag -ve before treatment started.
Thank you
it's an old article from 2008 with comparison of all drugs and results which is still valid except for tdf which is missing.sebvivo has a 20% resistance at 2 years so i'd choose tdf or etv
http://www.google.it/imgres?imgurl=http://img.medscape.com/fullsize/migrated/579/413/jgh579413.fig3.gif&imgrefurl=http://www.medscape.com/viewarticle/579413_1&usg=__lKOSHTlVzNutZjKu8XE3qWUnTuM=&h=624&w=400&sz=23&hl=it&start=5&sig2=ZO2SLi1BPSyLCoIIp7jU5A&itbs=1&tbnid=ylm5qCQ-EJRGWM:&tbnh=136&tbnw=87&prev=/images%3Fq%3Dhbvdna%2Bdecline%2Bentecavir%26hl%3Dit%26safe%3Doff%26gbv%3D2%26tbs%3Disch:1&ei=krbiS8f9GdLAsgaf_aD1Dw
if you get hbvdna und by 6 months this is a very good drug with high hbe seroconversion and hbs seroconversion comparable with tdf
if hbvdna is positive after 6 month switch to another antiviral because resistance is very probable
google sebvivo vienna congress easl 2010 or sebvivo hbsag kinetics for more info
i personally prefer etv and tdf which have very low/no resistance rates, sebvivo is very dangerous on this if hbvdna is not und fast
if hbvdna is positive after 6 month switch to another antiviral because resistance is very probable
google sebvivo vienna congress easl 2010 or sebvivo hbsag kinetics for more info
i personally prefer etv and tdf which have very low/no resistance rates, sebvivo is very dangerous on this if hbvdna is not und fast
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