I have been on 0.5mg entecavir for about six years and my viral load is still detectable at some 180 copies/ml. My ALT has been normal. I am just afraid that I already have entecavir resistance mutations rendering a higher HCC risk. Any help is greatly appreciated. Thanks a lot.
I met my doctor today and he suggested me to increase the dosage of entecavir from 0.5mg to 1 mg though he was of the view that such change may further reduce the viral load but just not cost-effective. He said this treatment is better than etc+tdf combo in that I should be no problem of sides after increasing the dose and I still have tdf as a backup in case of need. Any advice from you is very much appreciated. Many thanks.
etv 0.5mg or 1mg are the same potency, the 1mg dose was thought to be more potent on resistance development only
if etv 0.5mg doesn t work it is useless to increase dose, in my case researchers added tdf for hbvdna being between 10-15iu/ml, i asked them for etv 1mg and they said you just increase possible sides with no effect
why to stay with etv if tdf is more potent, free of resistance and cheaper?ask this to your doctor and double check if he has any connections with etv sales (possible hidden drug makers benefits vs sales).
if you add etv+tdf you can stop etv after 6months on the combo if hbvdna und
So should I insist etv + tdf combo when I see him next time? Btw, I also asked whether I should use interferon and he estimated that my chance of success is low (I am still e-antigen +ve). Any views about the use of interferon on my case?
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