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Should i take Peg-IFN now ?
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Should i take Peg-IFN now ?

Hello, I am SiZ ,

{ my story >> i have get HBV When i way only 19 years old at 2009 , i got my HBV from a clinical perform from needle .... , after that now my age is 24 and my ALT= normal .., HBeAg is negative, and DNA = 4000 , ( normally is 2000 ) my DNA Is higher }

I have been on follow Up for 4 years with HBV , Now My last test result's ( ALT, DNA, HBeAg ,Fibroscan ) == { , HBeAg-negative(0.41) , ALT= Normal (20) , DNA= 4000,Fibroscan- 6.2(stiffness)} , Now my OLD Liver Specialist Said to me to take Peg-IFN , And I have get find a younger Liver Specialist WHO is the Member of AASLD and EASL and More .. , He is suggest me to take Peg- IFN ( 48 weeks ) , I may Going to Take Peg-IFN .

Question : 1, Should It will be Better idea to start my treatment with Peg-IFN { My ALT is Now Normal and DNA is 4000 }

2 , What Should I Care when i am Taking Peg-IFN ? Any tips for Avoiding Side-effect From the Peg-IFN ?

3, Any chance to Cure from this stage ?

Note: {  My doctor told me to start take peg-IFN 48 weeks, and i have search for this treatment and i have find this is that " if anyone can get long time CHB And after that if he get " ALT= rising .., HBeAg is negative, and DNA >2000 , ( now my DNA is 4000 ) " should treated with peg-IFN for long time morethem 6 month's , but now my question is my ALT is normal and my virus load is higher ...=-> am i the right person to get this treatment and my ultrasound report was might i am with CHB And the big question is , is it works for me ? }

Note: { My ultrasound Report is ="The lives is larger in size.

The hepatic tissue character is course and uniformly low echogenic.

The hepato tree is not dilated.

The gall bladder is normal in appearance .

The spleen is normal in size but uniformly low echogenic in tissue patern .

The pesitoneal & does not contain asiuthsic fluid.

"

Note : i am sorry to say that, i am not a doctor and my ultrasound report are written by a doctor hand writing mode and for that coz i haven't read the all sentence , his hand writing is complex and if anyone would like to see my original scan copy , please message me..

Hope everybody understand .. }




Please Reply Me if you Wanna HELP me ....
Tags: IFN, negative, peginterferon, 48 week treatment, Hepatitis B
25 Comments Post a Comment
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Avatar_m_tn
You are missing the most important test to monitor your status, see if you are clearing hbv and predict hbv cure by peginterferon which is hbsag quantitative in iu/ml.how come this fundamental test is missing from your reports? It makes no sense to propose peg without hbsag quant and hbv genotype

after you have those tests we can say how peg will respond
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Avatar_m_tn
U also need to check your vitd serum levels which are low on almost hbv carriers, low vit d makes peg failure and more liver damage anyway.test is vitd25oh and optimum levels around 90-100ng/ml, deficency less than 30 and norm levels 30-100ng/ml
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Avatar_m_tn
Are you aware of studies on 1.25D levels (not vit d25) on hbv patients? ...could not find any on the web.
Also on hbv downregulating VitDReceptors (like the one for hep C).
Or gcmaf bringing down 1.25d?
Thanks in advance
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7522097_tn?1391583934
thanks to reply ..

i am really sorry for my late reply and my all test report's are here , please check:

DNA result: 3096 copies/ml log value 3.49


HBsAg (comfirmation) serum by CMI CONFIRMED POSITIVE

HBeAg NON REACTIVE (0.41)

Fibroscan done 24/08/13 6.2

Fibroscan done 01/02/14 4.6


My ultrasound Report is ="The lives is larger in size.
The hepatic tissue character is course and uniformly low echogenic.
The hepato tree is not dilated. The gall bladder is normal in appearance .

The spleen is normal in size but uniformly low echogenic in tissue patern .

The peritoneal sac does not contain ascitic fluid. Sonological findings are in favor of chronic viral hepatitis.
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7522097_tn?1391583934
Thank you all for reply ....

Now i have update my report's and ultrasound also ..

Request to see my last commet . And please tell me ...

Should i take peg-IFN  ?

Can peg-IFN  will be very  danger for me ?

Can Peg-IFN might cure or risk free on my liver ?

Note : My doctor said to me to take only Peg-IFN without any oral antiviral .
* He doesn't want to give me any oral antiviral drug also...

_-_-__| Link might similar |_-_-_-

http://www.medhelp.org/posts/ Hepatitis-B/Hbeag/show/1597990


This airtiale is confuse me link = http://www.hbvadvocate.org/ news/AASLD%202012%20HBV% 20Coverage.htm
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Avatar_m_tn
As long as you're so young I'd say at least give a try.. i'm sure you'll tolerate sides... I did not have any side for 2 ifn courses.. so i think you'll have the same..
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7522097_tn?1391583934
Thanks for reply , But how do you take    2 ifn courses for treatment ?

And now what about you ? Have you cure HBV ?

And which brand you was used ? If will be better he you give me personal message for this off topic ...

Hope you are understand ..
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Avatar_m_tn
If u dont have hbsag quant and genotype you cant have peg and monitor response
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7522097_tn?1391583934
so , what should i do before start peg-IFN Treatment ?

And how i can get success rate ?

Is there any chance to remove or inactive the HBV ?

Can i save my liver from the HBV ?

And how do i monitor my treatment progress ? Or How to i know is peg-IFN is working or not ?

And how long time after check to see is it working or not ...
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Avatar_m_tn
Hbv infection is hbsag detectable, it is obvious its quantification is mandatory, hbsag less than 1000iu/ml has th3 highest responce of pegintf
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Avatar_m_tn
yes I had 2 courses...  but none of them worked so i'm still hbsag+ve but hbeag+ve also...

you can minimize risk of sides by resting/sleepin when you feel this need, drink a lot of water and take paracetamol when needed..

do not be afraid... try!!!!!!!
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Avatar_m_tn
If your Dr want to prescribed IFN, you should do it.

Is it cost effective in your medicals?

It's definitely worth a shot. Although like Stef said, you might want to measure your HBsAG first as a baseline.



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7522097_tn?1391583934
Last saturday i have finished my 2nd short of 48..

Should i take any blood test for ensure my sides ?

And thanks for your comment
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Avatar_m_tn
the most important thing at start is be sure your vitd25oh is above 50ng/ml (check that unit is ng/ml, nmol/l is different scale).around 90ng/ml might be optimum levels

with low vitd25oh there is peg non response

high vit d levels boot pegintf response and might help a little with inflammation

also 4cup of coffee per day can increase peg response and in general are a must because it can block/reduce firbosis of the liver
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Avatar_m_tn
Blood test usually after 2 or 4 weeks. Your neutrophils level will be low and I guess you will want a high ALT. GL.



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7522097_tn?1391583934
So ... I am Going To take a blood Test for see my sides , and What Test will be shown that is this PegIFN Treatment is Working or Not ?

How Do i get full response of my 48 weeks Peg_IFN Treatment ?

My Doctor give me Alone full peg-IFN ( 180 micrograms/0.5 ml ) Brand Name is " Pegasys (  ) "



, And Very thanks for your Replay ...
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7522097_tn?1391583934
High ALT. GL.  :O  , Should I need high ALT ?
Actually I want to cure from this worse HBV ....

I Love my Life ... I like to be with you this universal ,

I am Sorry for this speech ,  
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Avatar_m_tn
two main tests for you to see if inf is working is HBV DNA and qHbsag but you need to know your baseline before you start inf injections. If you do not know your base line you treatment will be blind.
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7522097_tn?1391583934
Could you like to tell me in details about   baseline  ... And  How do i know the baseline ?

Thanks for your Comment ..
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Avatar_m_tn
you need to have your HBVDNA and qHbsag results done before treatment  and during so you can see if inf works or not! If no decrase in hbvdna and qhbsag then theraphy is not working. Your test result before theraphy is started called baseline.
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7522097_tn?1391583934
thanks for your reply ... You will glade to know that i have already done thous test and i have also post thous all report's on this post body ...
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Avatar_m_tn
You do not have this test among the tests that you have posted above.
Make sure that you do hbsag quantitive test in iU/ml with delusion. Better post the result here so we could tell if this test is good or not.

A decrease of 0.5 and 1 log(10) IU/mL in serum HBsAg levels at weeks 12 and 24 of therapy, respectively, is high predictor of response to treatment.

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7522097_tn?1391583934
If you don,t mind , Can i Send a personal Message , I wanna share my Original Test copy,s and I have to need some advice about my treatment duration ..

Hope you Understand ..

Waiting for replay
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Avatar_m_tn
No problems, but it is better to post on forum so you could get advice from other members too.
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Avatar_m_tn
High ALT mean your ALT spike up after a few injections. But then again, with paris2013, his ALT stayed low while his HBsAg declined to zero.

As with Cyrus131, not so sure about his ALT. He did not post his ALT level during his 45 weeks so far.

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