Sudden Increase in ALT/AST after stopping Ntz and LIv 52 HB increases HbsAg

[smile_boy]

Hi Stef and Others,

There is a sudden increase in my AST and ALT values after stopping Ntz. I stopped Ntz in August 2011 end and later I started taking Liv52 HB.

Results on Feb-2012:-
ASPARTATE AMINOTRANSFERASE (SGOT )PHOTOMETRY =98.00 U/l M: 0 to 37 - F: 0 to 31
ALANINE TRANSAMINASE (SGPT) PHOTOMETRY = 244.00 U/l M: 0 to 37 - F: 0 to 31

ALKALINE PHOSPHATASE PHOTOMETRY =98.30 U/l M:53 to 128 - F:42 to 98
BILIRUBIN -DIRECT PHOTOMETRY =0.26 mg/dl 0 - 0.3
BILIRUBIN - TOTAL PHOTOMETRY= 0.85 mg/dl 0 - 1.2
BILIRUBIN (INDIRECT) CALCULATED =0.59 mg/dl 0 - 0.9
GAMMA GLUTAMYL TRANSFERASE (GGT)PHOTOMETRY =21.00 U/l M: 0 to 50 - F :0 to 30
PROTEIN - TOTAL PHOTOMETRY =8.30 gm/dl 6.0 - 8.3
ALBUMIN - SERUM PHOTOMETRY= 4.56 gm/dl 3.2 - 5.0
SERUM ALBUMIN/GLOBULIN RATIO CALCULATED =1.22 Ratio 0.9 - 2.0
25-OH VITAMIN D TOTAL= 37.26 ng/ml
HbsAg Quant - 1789 iu/ml



Results on Aug -2011:-
SGOT - 25.90
SGPT - 38.90
HbsAG - 733 iu/ml

Almost SGPT has increased 10 times. Kindly help me. I'm very scared about my situation. If stopping ntz increases ALT ans AST ,we cannot take ntz for life long? please help

[smile_boy]

Hi Stef 2011 and Stephen

could you please comment on my LFT reports . Thank you very much in advance

[smile_boy]

LKALINE PHOSPHATASE PHOTOMETRY 64.8 U/l                                                  M:53 to 128 - F:42 to 98
BILIRUBIN - TOTAL PHOTOMETRY 0.84 mg/dl                                                           0.30 - 1.20
BILIRUBIN -DIRECT PHOTOMETRY 0.26 mg/dl                                                           0 - 0.20
BILIRUBIN (INDIRECT) CALCULATED 0.58 mg/dl                                                         0 - 0.9
ASPARTATE AMINOTRANSFERASE (SGOT ) PHOTOMETRY 201.3 U/l                       M: 0 to 37 - F: 0 to 31
ALANINE TRANSAMINASE (SGPT) PHOTOMETRY 506 U/l                                          M: 13 to 40 - F: 10 to 28
GAMMA GLUTAMYL TRANSFERASE (GGT) PHOTOMETRY 21.8 U/l M:                      0 to 55 - F :0 to 38
PROTEIN - TOTAL PHOTOMETRY 7.35 gm/dl                                                              6.6 - 8.3
ALBUMIN - SERUM PHOTOMETRY 4.22 gm/dl                                                            3.5 - 5.2
SERUM ALBUMIN/GLOBULIN RATIO CALCULATED 1.35                                             Ratio 0.9 - 2.0


My ALT = 506 and AST = 201.3 which  is very high for almost past 2 years. Yet to take DNA and QHbsAg. Could you please help me on this. Also BILIRUBIN -DIRECT PHOTOMETRY is 0.26 mg/dl  where normal range is  0 - 0.20.

[smile_boy]

thank you very much for your kind reply

[studyforhope]

No, proinflammatory cytokines like eg tnfalpha or interleukin6 are also inhibitory for hbv replication and transcription, but not efficient in the elimination of cccDNA.

Ifngamma in high local concentrations is efficient to eliminate cccdna.It is produced by activated cd8 cells that have encountered their specific recognized epitope presented on the surface of an infected liver cell.

Anti inflammatory cytokines like Il10 will inhibit tcell activation and help hbv to replicate.

[smile_boy]

Pro Inflammatory Cytokines are of importance in chronic inflammatory stage. It of course helps HBV virons to replicate more and helps HBV virus growth.

Anti-Inflammatory cytokines are good for host and also it produces sufficient IFIN.

[smile_boy]

thanks for reply. Yes you are right. I Have mild  swelling in the liver area and frequent piercing pain.